142 completed. 142 Phase 2, 28 Phase 1, 26 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 142 | Completed 142 |
| Phase 1 | 28 | Completed 28 |
| Phase 3 | 26 | Completed 26 |
Follow Shock: new trials by email Literature Review of Shock trials Research Report on Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock Norepinephrine, Ringer's Lactate - Septic Shock, Sepsis | Phase 2 / Phase 3 | Completed | Universitas Indonesia | 42 | 2024-03-25 | 2024-06-20 |
| Multimodal Vasopressor Strategy in Septic Shock Simultaneous administration of vasopressors, Successive administration of vasopressors - Shock, Septic | Phase 2 / Phase 3 | Completed | University Medical Centre Maribor | 79 | 2023-12-23 | 2026-03-31 |
| Strong Albumin Solutions in Patients With Septic Shock hyperoncotic human albumin solution, Buffered crystalloid solutions - Sepsis, Septic Shock | Phase 2 / Phase 3 | Completed | Manchester University NHS Foundation Trust | 47 | 2023-11-10 | 2026-02-09 |
| Safety and Feasibility of Metformin for Sepsis Induced AKI Metformin low dose, Metformin high dose, Placebo - Sepsis, Septic Shock | Phase 2 | Completed | Hernando Gomez | 80 | 2023-11-08 | 2026-06-09 |
| Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis apigenin, sterilized water - Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | Zhujiang Hospital | 20 | 2023-09-01 | 2024-03-13 |
| Low Dose Versus High Dose Methylene Blue in Septic Patients Normal saline, Methylene Blue low dose, Methylene Blue high dose - Septic Shock | Phase 2 / Phase 3 | Completed | National Cancer Institute, Egypt | 90 | 2023-08-01 | 2024-07-05 |
| Effects of Paroxetine on Cardiovascular Function in Septic Patients Paroxetine - Septic Shock, Sepsis | Phase 2 | Completed | Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude | 130 | 2023-06-10 | 2026-08-24 |
| Midodrine Effect on the Mortality Rates in Septic Shock Patients Midodrine Oral Tablet - Septic Shock | Phase 2 | Completed | Noha Mansour | 100 | 2022-11-07 | 2025-03-03 |
| CONFOCAL-2 Interventional Pilot Study Autoregulation-based precision blood pressure management - Critical Illness, Respiratory Failure | Phase 1 / Phase 2 | Completed | Queen's University | 16 | 2022-07-29 | 2025-12-22 |
| Cold Stored Platelet in Hemorrhagic Shock Cold Stored Platelets (CSP), Standard Care - Trauma, Hemorrhage | Phase 2 | Completed | Jason Sperry | 200 | 2022-06-21 | 2024-12-18 |
| Jafron Haemoadsorption During Cardiopulmonary Bypass Jafron use during CPB - Cytokine Release Syndrome | Phase 2 | Completed | Anthea Hospital Bari | 40 | 2022-05-30 | 2023-02-24 |
| Thyroid Hormone Supplementation in Patients With Septic Shock triiodothyronine - Euthyroid Sick Syndromes, Septic Shock | Phase 2 | Completed | Cantonal Hospital Zenica | 108 | 2022-05-01 | 2023-09-28 |
| Intravenous Metoprolol in Septic Shock Intravenous metoprolol tartrate, Standard Care (in control arm) - Septic Shock, Ventilator Acquired Pneumonia | Phase 2 | Completed | Alexandria University | 100 | 2022-04-01 | 2025-01-29 |
| Decatecholaminisation of Septic Shock With Dexmedetomidine and In-hospital Mortality Dexmedetomidine - Septic Shock, Sepsis | Phase 2 | Completed | Mansoura University | 90 | 2022-03-25 | 2023-05-06 |
| Clinical Efficacy of Megadose Vitamin C in Sepsis Vitamin C, 5% glucose injection - Sepsis, Septic Shock | Phase 2 | Completed | Zhujiang Hospital | 234 | 2022-02-08 | 2026-05-13 |
| Effect of Arterio-venous ECMO on Severe Sepsis and ARDS Meropenem Injection, A-V ECMO - Patients With Respiratory Failure and Shocked | Phase 1 / Phase 2 | Completed | Mohamed Gaber Allam | 100 | 2022-02-01 | 2022-04-12 |
| Comparison of Fluid Resuscitation in Pediatric Burn Patients Using Crystalloids and With Albumin on Day Two. 5% Albumin (human) Solution, Paeds solution - Burns | Phase 2 / Phase 3 | Completed | King Edward Medical University | 90 | 2022-01-01 | 2024-01-25 |
| Effect of Ivabradine on Microcirculation and Cardiac Output in Septic Shock Patients Ivabradine 5mg Tab, Placebo - Septic Shock | Phase 2 | Completed | Cairo University | 44 | 2021-11-25 | 2022-09-01 |
| Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy Siltuximab - Cytokine Release Syndrome, ICANS | Phase 2 | Completed | University of Alabama at Birmingham | 20 | 2021-11-15 | 2026-07-27 |
| Methylene Blue for the Prevention of Hypotension During Hemodialysis Methylene Blue, Control - Acute Kidney Injury, Shock | Phase 2 | Completed | Federal University of São Paulo | 261 | 2021-10-21 | 2026-04-17 |
Showing 20 of 142. Sign in to see all of them.
Shock, Septic (84) · Sepsis (55) · Cytokine Release Syndrome (18) · COVID-19 (13) · Systemic Inflammatory Response Syndrome (12) · Wounds and Injuries (9) · Multiple Organ Failure (7) · Shock, Hemorrhagic (7) · Acute Kidney Injury (6) · Diabetes Insipidus (6) · Hemorrhage (6) · Critical Illness (5) · Pneumonia (5) · Infections (4)
Pathological Conditions, Signs and Symptoms (142) · Pathologic Processes (141) · Inflammation (110) · Systemic Inflammatory Response Syndrome (101) · Infections (99) · Sepsis (34) · Respiratory Tract Diseases (21) · Lung Diseases (20) · Cardiovascular Diseases (16) · Respiratory Tract Infections (16) · Female Urogenital Diseases (14) · Female Urogenital Diseases and Pregnancy Complications (14) · Kidney Diseases (14) · Male Urogenital Diseases (14)
Sodium Chloride (15) · Saline Solution (11) · Ascorbic Acid (8) · Standard of Care (7) · Hydrocortisone (6) · Thiamine (6) · Norepinephrine (5) · Meropenem (4) · Vasopressins (4) · AZD9773 (3) · Albumins (3) · Bronchoscopy (3) · CytoFab (3) · Epinephrine (3) · Methylene Blue (3)
University of Roma La Sapienza (6) · Beth Israel Deaconess Medical Center (5) · AstraZeneca (3) · King Abdul Aziz Specialist Hospital (3) · Zhujiang Hospital (3) · Austin Health (2) · Australian and New Zealand Intensive Care Research Centre (2) · CalciMedica, Inc. (2) · Children's Hospital Medical Center, Cincinnati (2) · Christian Hassager (2) · Ferring Pharmaceuticals (2) · GlaxoSmithKline (2) · InflaRx GmbH (2) · Jinhua Central Hospital (2) · Mansoura University (2)
United States (41) · France (13) · Canada (12) · Germany (12) · Italy (12) · Denmark (9) · Australia (8) · Belgium (8) · Egypt (8) · China (7) · Spain (7) · Netherlands (6) · Brazil (5) · India (5) · Saudi Arabia (5)
Andrea Morelli, MD (5) · Michael W Donnino, MD (4) · Eric Bellissant, MD, PhD (3) · Wayne Dankner, MD (3) · Andrea Morelli, M.D. (2) · Christian Hassager, MD, DMSc (2) · Justin Lindemann, MD (2) · Karim Brohi, MD (2) · Sudarshan Hebbar, MD (2) · Warren Botnick, MD (2) · Zhanguo Liu, M.D.PhD (2) · Abele Donati, MD (1) · Ahmed Mohamed Mukhtar, M,D (1)
PMID 23001587, PMID 16507156, PMID 16553654, PMID 17617901, PMID 17720019, PMID 18805742, PMID 19017409, PMID 19048243, PMID 19114895, PMID 19114908, PMID 19280394, PMID 19664253, PMID 20809942, PMID 20955600, PMID 21132310, PMID 21182783, PMID 21190486, PMID 21371308, PMID 21615299, PMID 21827677, PMID 21929764, PMID 22071998, PMID 22961865, PMID 23374652, PMID 23681364, PMID 23857856, PMID 24108526, PMID 24484547, PMID 24794878, PMID 25029202, PMID 25407570, PMID 25456364, PMID 25855898, PMID 25947955, PMID 26605292, PMID 26703919, PMID 27038920, PMID 27296693, PMID 27318038, PMID 28203424, PMID 28367008, PMID 28729329, PMID 28807037, PMID 29351985, PMID 29361959, PMID 30074491, PMID 30100052, PMID 30123523, PMID 30255316, PMID 30566758
2017 (2), 2019 (2), 2005 (1), 2015 (1), R01DK133142 (1), U01HL077863 (1)