122 completed, 33 unknown, 24 terminated, 7 withdrawn. 48 Not applicable, 27 Phase 2, 26 Phase 3, 16 Phase 4, 5 Phase 1.
Follow Severe Sepsis: new trials by email Literature Review of Severe Sepsis trials Research Report on Severe Sepsis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis Sepsis, Severe Sepsis | Not yet recruiting | The University of Texas Health Science Center, Houston | 30 | 2026-12-01 | 2025-06-11 | |
| Plasma Exchange in Children With Severe Sepsis and Septic Shock Plasma exchange (PE) - Severe Sepsis | Not applicable | Recruiting | Menoufia University | 22 | 2026-08-01 | 2026-10-07 |
| Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy - Observational Long-term Outcome Follow up Severe Sepsis | Recruiting | Artcline GmbH | 142 | 2024-01-01 | 2024-08-02 | |
| Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality Ulinastatin - Severe Sepsis, Septic Shock | Phase 4 | Unknown | Jinnah Postgraduate Medical Centre | 175 | 2023-05-01 | 2023-06-08 |
| Symphony IL-6 Study in Patients at Risk of Severe Sepsis Severe Sepsis | Unknown | Bluejay Diagnostics, Inc. | 200 | 2022-11-22 | 2023-09-07 | |
| Gram Type Infection-Specific Sepsis Identification Using Machine Learning InSight - Sepsis, Severe Sepsis | Phase 2 | Withdrawn | Dascena | 2022-05-01 | 2021-09-23 | |
| A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children Not applicable（Cohort study） - Critical Illness, Severe Sepsis | Recruiting | Children's Hospital of Fudan University | 5000 | 2022-04-30 | 2026-03-16 | |
| Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment Treatment-specific InSight, InSight - Sepsis, Severe Sepsis | Phase 2 | Unknown | Dascena | 51645 | 2022-04-01 | 2021-09-23 |
| Machine Learning Sepsis Alert Notification Using Clinical Data HindSight, InSight - Sepsis, Severe Sepsis | Phase 2 | Unknown | Dascena | 37986 | 2021-09-25 | 2022-05-03 |
| Sepsis Post Market Clinical Utility Simple Endpoint Study - HUMC Diagnostic Test: CBC-DIFF Monocyte Volume Width Distribution (MDW) - Sepsis, Adult Disease | Completed | Beckman Coulter, Inc. | 198 | 2021-09-05 | 2022-07-18 | |
| Symphony IL-6 Cutoff Establishment Study for Patients at Risk of Severe Sepsis Due to COVID-19 Severe Sepsis | Unknown | Bluejay Diagnostics, Inc. | 96 | 2021-08-31 | 2023-08-15 | |
| Symphony IL-6 Cutoff Validation Study for Patients at Risk of Severe Sepsis Severe Sepsis | Unknown | Bluejay Diagnostics, Inc. | 48 | 2021-08-31 | 2023-08-14 | |
| Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia Monocyte Distribution Width (MDW) , observation - Bacteremia, Bacteremia Sepsis | Active not recruiting | Henry Ford Health System | 50000 | 2021-07-01 | 2026-05-12 | |
| ED Tracking Sheet Implementation ED Sepsis Tracking Sheet - Sepsis, Severe Sepsis | Not applicable | Completed | Dartmouth-Hitchcock Medical Center | 194 | 2021-07-01 | 2023-05-19 |
| Sepsis Post Market Clinical Utility Simple Endpoint Study - Indiana University Hospital CBC-DIFF Monocyte Volume Width Distribution (MDW) - Sepsis, Adult Disease | Completed | Beckman Coulter, Inc. | 127 | 2021-06-17 | 2022-07-18 | |
| Clinical Study on Monitoring the Plasma Concentration of Ceftazidime-Avibactam in Critically Ill Patients Ceftazidime-avibactam - Severe Sepsis, Carbapenem Resistant Bacterial Infection | Completed | First Affiliated Hospital of Zhejiang University | 33 | 2021-06-01 | 2026-09-10 | |
| Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol Severe Sepsis, Severe Sepsis Without Septic Shock | Enrolling by invitation | Beckman Coulter, Inc. | 40000 | 2021-02-15 | 2024-06-21 | |
| Subpopulation-Specific Sepsis Identification Using Machine Learning CustomSight - Sepsis, Severe Sepsis | Phase 2 | Withdrawn | Dascena | 2020-12-01 | 2021-09-23 | |
| Sepsis Post Market Observational Study and Potential Reduction of Time to Antibiotics - Washington University CBC-DIFF Monocyte Volume Width Distribution (MDW) - Sepsis, Adult Disease | Completed | Beckman Coulter, Inc. | 1139 | 2020-02-03 | 2021-03-17 | |
| RCT of Sepsis Machine Learning Algorithm InSight - Sepsis, Severe Sepsis | Phase 2 | Withdrawn | Dascena | 2020-01-01 | 2021-09-23 |
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Sepsis (193) · Shock, Septic (103) · Systemic Inflammatory Response Syndrome (11) · Disease (10) · Infections (10) · Emergencies (9) · Critical Illness (8) · Multiple Organ Failure (8) · Respiratory Insufficiency (5) · Acute Kidney Injury (4) · Shock (4) · Acute Lung Injury (3) · Bacteremia (3) · Death (3) · Heart Arrest (3)
Pathologic Processes (193) · Pathological Conditions, Signs and Symptoms (193) · Inflammation (191) · Infections (183) · Systemic Inflammatory Response Syndrome (182) · Shock (106) · Disease Attributes (18) · Respiratory Tract Diseases (11) · Respiration Disorders (9) · Bacterial Infections (6) · Bacterial Infections and Mycoses (6) · Lung Diseases (6) · Signs and Symptoms (6) · Cardiovascular Diseases (5) · Female Urogenital Diseases (5)
Standard of Care (4) · AZD9773 (3) · Albumins (3) · Blood Specimen Collection (3) · CytoFab (3) · Norepinephrine (3) · Renal Replacement Therapy (3) · Ceftriaxone (2) · Continuous Renal Replacement Therapy (2) · Dobutamine (2) · Docosahexaenoic Acids (2) · Drug Delivery Systems (2) · Early Goal-Directed Therapy (2) · Fatty Acids, Omega-3 (2) · Fluid Therapy (2)
Dascena (8) · Beckman Coulter, Inc. (6) · Vanderbilt University (4) · Assistance Publique - Hôpitaux de Paris (3) · AstraZeneca (3) · Bluejay Diagnostics, Inc. (3) · Bristol-Myers Squibb (3) · Center for Sepsis Control and Care, Germany (3) · Chang Gung Memorial Hospital (3) · Chinese PLA General Hospital (3) · Mahidol University (3) · National Taiwan University Hospital (3) · University of Oxford (3) · Agennix (2) · Amsterdam UMC, location VUmc (2)
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Ritankar Das, MSc (4) · Djillali Annane, MD, PhD (3) · Konrad Reinhart, MD (3) · Luciano Gattinoni, MD (3) · Wayne Dankner, MD (3) · Benjamin L Andrews, MD (2) · Christian P Subbe, MD (2) · Eric Bellissant, MD, PhD (2) · Justin Lindemann, MD (2) · Michael Lanspa, MD (2) · Ryan Arnold, MD (2) · Thomas Deufel, MD (2) · Warren Botnick, MD (2)
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R24TW007988 (2), 1RC3GM093717-01 (1), 2004 (1), 2005 (1), 2014 (1), K23HL105654 (1), P01HL108801 (1), P30CA016672 (1), R01HL055330 (1), R01HL091757 (1), R01HL113382 (1), R25TW009337 (1), R44AA030000 (1)