Sepsis: Clinical Trials

1726 completed, 691 unknown, 323 recruiting, 199 not yet recruiting. 867 Not applicable, 345 Phase 2, 333 Phase 3, 243 Phase 4, 142 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	867	Completed 465, Unknown 164, Recruiting 92, Not yet recruiting 57, Terminated 46, Withdrawn 25, Active not recruiting 11, Suspended 4, Enrolling by invitation 3
Phase 2	345	Completed 183, Unknown 60, Terminated 39, Recruiting 20, Withdrawn 19, Not yet recruiting 13, Active not recruiting 7, Suspended 3, Enrolling by invitation 1
Phase 3	333	Completed 176, Unknown 51, Terminated 45, Recruiting 25, Not yet recruiting 14, Withdrawn 11, Active not recruiting 6, Suspended 5
Phase 4	243	Completed 123, Unknown 45, Terminated 26, Recruiting 24, Not yet recruiting 11, Withdrawn 8, Active not recruiting 5, Enrolling by invitation 1
Phase 1	142	Completed 101, Terminated 12, Unknown 8, Withdrawn 7, Recruiting 6, Not yet recruiting 5, Active not recruiting 2, Enrolling by invitation 1
Early Phase 1	10	Completed 4, Not yet recruiting 2, Recruiting 2, Active not recruiting 1, Unknown 1

Follow Sepsis: new trials by email Literature Review of Sepsis trials Research Report on Sepsis

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Extended vs. Intermittent Meropenem Infusion in Sepsis Patients in the ICU Extended beta-lactam antibiotics, Intermittent Beta-lactam antibiotics - Sepsis, Septic Shock		Not yet recruiting	Assiut University	90	2027-10-01	2026-09-01
Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy • Sivelestat intravenous infusion, NaCl intravenous infusion - Septic Shock, Coagulopathy	Phase 2	Not yet recruiting	University Hospital, Strasbourg, France	120	2027-08-01	2026-08-20
G-CSF In Neonatal Sepsis With Neutropenia Granulocyte-colony stimulating factor (G-CSF), Standard Sepsis Management - Neonatal Sepsis, Neutropenia	Not applicable	Not yet recruiting	University of Health Sciences Lahore	52	2027-02-15	2026-10-22
The Extended Study of Prevalence of Infection in Intensive Care IV Sepsis, Infection		Not yet recruiting	Universidad de la Sabana	10000	2027-02-01	2026-06-29
Biological Effects of Hemoadsorption in Septic Shock Hemoadsorption cartridge - Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction	Not applicable	Not yet recruiting	Miguel Sanchez Garcia	16	2027-01-07	2026-07-20
Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress Lift mobile mindfulness, Enlighten Recovery education program - Critical Illness, Heart Failure	Not applicable	Not yet recruiting	Duke University	450	2027-01-01	2026-07-08
Remote Ischemic Postconditioning in Septic Shock Remote ischemic conditioning, No intervention - Adult Patients With Septic Shock Admitted in Intensive Care Unit	Not applicable	Not yet recruiting	Hospices Civils de Lyon	720	2027-01-01	2026-10-09
SWedish Intensive Care Biobank Any Condition Underlying Critical Illness		Not yet recruiting	Uppsala University	25000	2027-01-01	2026-05-13
Immune Dysregulation During Sepsis: A Natural History Cohort Sepsis, Septic Shock		Not yet recruiting	National Heart, Lung, and Blood Institute (NHLBI)	500	2027-01-01	2026-10-09
Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis Para-Tyrosine supplementation, Placebo solution - Sepsis	Phase 2	Suspended	University of Pecs	296	2027-01-01	2025-03-30
Prediction and Prevention of Bloodstream Infections After Kidney Transplantation Pivmecillinam, Placebo - Kidney Transplant Infection, Bloodstream Infection	Phase 3	Not yet recruiting	Susanne Dam Nielsen, MD, DMSc	180	2027-01-01	2026-10-16
Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis Sepsis, Severe Sepsis		Not yet recruiting	The University of Texas Health Science Center, Houston	30	2026-12-01	2025-06-11
Cahnge in Management of Suspected Early Onset Neonetal Sepsis After Assimilation of Early Onset Sepsis Calculator No intervention - Neonatal Early-onset Sepsis		Not yet recruiting	Hillel Yaffe Medical Center	6300	2026-12-01	2026-04-07
THiamine for Recovery In Vulnerable Early-life Infections thiamine hydrochloride 100 mg, Placebo - Meningitis, Bacteremia	Phase 2	Not yet recruiting	Milton S. Hershey Medical Center	240	2026-12-01	2026-10-09
Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit 13C6-Glucose - Glucose, Metabolism	Not applicable	Not yet recruiting	Vanderbilt University Medical Center	25	2026-11-01	2026-09-09
Core-to-Big-Toe Temperature Gradient as a Marker of Peripheral Perfusion in Adult Patients With Septic Shock Septic Shock, Sepsis		Not yet recruiting	Assiut University	54	2026-11-01	2026-10-13
Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples InfectID-BSI (Bloodstream Infection) qPCR Assay - Bloodstream Infection, Sepsis		Not yet recruiting	Microbio Co Ltd	1500	2026-11-01	2026-10-08
Serial Platelet Count and Indices for Predicting In-Hospital Mortality in Sepsis Serial Complete Blood Counts (CBC) - Sepsis		Not yet recruiting	Assiut University	120	2026-11-01	2026-09-22
Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock Angiotensin II, Norepinephrine - Septic Shock	Phase 4	Not yet recruiting	Wake Forest University Health Sciences	78	2026-11-01	2026-09-24
Sepsis Biomarker Monitoring in Burn Patients PSP Monitoring - Sepsis, Burn	Not applicable	Not yet recruiting	Texas Tech University Health Sciences Center	120	2026-11-01	2026-10-08

Showing 20 of 3328. Sign in to see all of them.

Narrower conditions

Shock, Septic (1058)  ·  Bacteremia (259)  ·  Critical Illness (189)  ·  Neonatal Sepsis (188)  ·  Infections (185)  ·  Acute Kidney Injury (136)  ·  Shock (97)  ·  Pneumonia (93)  ·  Systemic Inflammatory Response Syndrome (88)  ·  Inflammation (87)  ·  Respiratory Distress Syndrome (81)  ·  Endotoxemia (80)  ·  Multiple Organ Failure (74)  ·  Candidemia (68)

Broader conditions

Pathological Conditions, Signs and Symptoms (3328)  ·  Pathologic Processes (3315)  ·  Inflammation (3241)  ·  Systemic Inflammatory Response Syndrome (3240)  ·  Infections (3143)  ·  Shock (1100)  ·  Bacterial Infections and Mycoses (426)  ·  Urogenital Diseases (348)  ·  Disease Attributes (338)  ·  Respiratory Tract Diseases (326)  ·  Female Urogenital Diseases and Pregnancy Complications (323)  ·  Bacterial Infections (292)  ·  Lung Diseases (257)  ·  Female Urogenital Diseases (246)

Interventions

Blood Specimen Collection (71)  ·  Saline Solution (64)  ·  Sodium Chloride (50)  ·  Norepinephrine (44)  ·  Standard of Care (42)  ·  Ascorbic Acid (41)  ·  Hydrocortisone (39)  ·  Meropenem (35)  ·  Thiamine (27)  ·  Vancomycin (27)  ·  Daptomycin (25)  ·  Dexmedetomidine (21)  ·  Piperacillin, Tazobactam Drug Combination (21)  ·  Gentamicins (18)  ·  Anti-Bacterial Agents (17)

Sponsors

Assistance Publique - Hôpitaux de Paris (59)  ·  Assiut University (48)  ·  Ain Shams University (39)  ·  Radboud University Medical Center (31)  ·  Southeast University, China (31)  ·  National Taiwan University Hospital (26)  ·  National Institute of Allergy and Infectious Diseases (NIAID) (25)  ·  Cairo University (24)  ·  Hospices Civils de Lyon (24)  ·  Tanta University (23)  ·  Pfizer (21)  ·  Chinese PLA General Hospital (20)  ·  Copenhagen University Hospital, Rigshospitalet (17)  ·  Peking Union Medical College Hospital (17)  ·  University of Florida (17)

Countries

United States (669)  ·  France (369)  ·  China (335)  ·  Germany (171)  ·  Egypt (154)  ·  Italy (143)  ·  Canada (124)  ·  Spain (115)  ·  United Kingdom (114)  ·  Netherlands (113)  ·  Turkey (Türkiye) (91)  ·  Belgium (90)  ·  Denmark (76)  ·  Brazil (73)  ·  Taiwan (67)

Top investigators

Peter Pickkers, MD, PhD (8)  ·  Andrea Morelli, MD (7)  ·  Bernd Jilma, MD (5)  ·  Claudia Spies, MD, Prof. (5)  ·  Evangelos Giamarellos-Bourboulis, MD, PhD (5)  ·  Evangelos J Giamarellos-Bourboulis, MD, PhD (5)  ·  Lixin Xie, MD (5)  ·  Niels Moeller, Professor (5)  ·  Philip Efron, MD (5)  ·  Anders Perner, MD, PhD (4)  ·  Ayman A Yousef, MD (4)  ·  Djillali Annane, MD, PhD (4)

Results publications

PMID 26903338, PMID 11445675, PMID 28459966, PMID 28597967, PMID 33891293, PMID 28101605, PMID 31280481, PMID 34605781, PMID 21516036, PMID 26903335, PMID 28343448, PMID 34519356, PMID 36416787, PMID 11794169, PMID 16424713, PMID 18158437, PMID 19531784, PMID 20179283, PMID 23353941, PMID 23899564, PMID 24171518, PMID 24794878, PMID 25392034, PMID 26903336, PMID 27940189, PMID 28871441, PMID 29084247, PMID 29784057, PMID 32520577, PMID 33620405, PMID 39716214, PMID 10470572, PMID 11395904, PMID 11588440, PMID 12500513, PMID 12519925, PMID 12720570, PMID 15276536, PMID 15636651, PMID 16134766, PMID 16497588, PMID 16855261, PMID 17334251, PMID 17638928, PMID 18090355, PMID 18434884, PMID 18457586, PMID 18533029, PMID 18702960, PMID 19926252

NIH funding

2014 (10), 2019 (9), 2025 (9), 2023 (8), 2017 (6), 2018 (6), 2005 (5), 2015 (5), 2016 (5), U10HD021373 (5), U10HD021385 (5), M01RR000070 (4), M01RR000750 (4), M01RR006022 (4), M01RR008084 (4)