35 completed, 13 unknown, 3 withdrawn, 2 active not recruiting. 20 Not applicable, 14 Phase 2, 7 Phase 3, 4 Phase 1, 3 Phase 4.
Follow Sialorrhea: new trials by email Literature Review of Sialorrhea trials Research Report on Sialorrhea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Local Vibration for Drooling in Children With Cerebral Palsy Local Vibration Therapy, Sham Vibration - Cerebral Palsy (CP) | Not applicable | Recruiting | Bitlis Eren University | 20 | 2026-06-15 | 2026-06-16 |
| Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve, Conventional Physical therapy, Conventional Speech Therapy - Transcutaneous Vagal Nerve Stimulation (tVNS), Parkinson Disease (PD) | Not applicable | Active not recruiting | Universidade da Coruña | 46 | 2026-05-25 | 2026-08-07 |
| Effectiveness of Neuromuscular Electrical Stimulation Added to Oral Motor Therapy in Cerebral Palsy Oral Motor Therapy, Neuromuscular Electrical Stimulation (NMES), Sham Neuromuscular Electrical Stimulation (Sham NMES) - Cerebral Palsy (CP), Drooling | Not applicable | Not yet recruiting | Aslinur Keles Ercisli, MD, PhD | 30 | 2026-05-01 | 2026-04-15 |
| Application of Neuro-electrostimulation as a Treatment for Patients With Dry Mouth electrotherapy and physical therapy device - Saliva Altered | Not applicable | Recruiting | Universidad Autonoma del Estado de Mexico | 35 | 2026-02-01 | 2026-05-18 |
| Effect of SCS Technique on Oromotor Skills in Children With CP Strain Counter-Strain (SCS), Designed Oral Motor Program - Sialorrhea, Spastic Cerebral Palsy (sCP) | Not applicable | Active not recruiting | Cairo University | 30 | 2026-01-20 | 2026-04-14 |
| A Retrospective Chart Abstraction to Investigate the Prevalence of Chronic Sialorrhea, and the Real-world Use of incobotulinumtoxinA Injections in Male and Female Participants Aged 18 Years and Older With Chronic Sialorrhea Sialorrhea | Completed | Medstar Health Research Institute | 206 | 2025-10-10 | 2026-10-19 | |
| Chewing Gum as a Therapeutic Intervention for the Management of Hypersalivation chewing gum mastication - Hypersialorrhea (Excessive Salivation), Psychiatric Disorders | Not applicable | Not yet recruiting | Centre Hospitalier de Cadillac | 46 | 2025-09-01 | 2025-09-05 |
| Botulinum Toxin Injections Into the Salivary Glands of Cerebrospinal Children With Chronic Sialorrhea Drooling, Brain Injuries | Completed | Centre Hospitalier Universitaire de Besancon | 5 | 2025-05-19 | 2025-07-24 | |
| The Application of Lidocaine Cream on Oral Secretions of LMA Removal During the Recovery Period in Ophthalmic Surgical Patients Under General Anesthesia lidocaine cream, Placebo - Airway Complication of Anaesthesia, Laryngeal Mask Airway Removal | Phase 4 | Withdrawn | Sun Yat-sen University | 2025-05-15 | 2025-05-29 | |
| Oral Structural and Functional Problems in Children With Autism oral assessment - Autism Spectrum Disorder, Chewing Problem | Unknown | Hacettepe University | 90 | 2024-04-11 | 2024-04-09 | |
| Cognitive-Integrated Soccer Training and Performance Cognitively Engaging Soccer Practice, Conventional Soccer Practice - Executive Function (Cognition), Soccer Training | Not applicable | Completed | Fan Mao | 64 | 2024-02-15 | 2026-07-07 |
| Effects of Mollii Suit in Children With Non-Ambule Cerebral Palsy EXOPULSE Mollii Suit method - Mollii Suit, Cerebral Palsy | Not applicable | Unknown | Kırıkkale University | 20 | 2024-01-20 | 2024-02-14 |
| Pharmacokinetics of Atropine Oral Gel Atropine sulfate gel (0.01%) - Cerebral Palsy, Sialorrhea | Early Phase 1 | Completed | University of Utah | 10 | 2022-10-01 | 2024-12-18 |
| Kinesio Taping Versus Oromotor Training on Drooling in Children With Spastic Cerebral Palsy KINESIOTAPE, oromotor training - Drooling, Kinesiotape | Not applicable | Completed | Cairo University | 30 | 2021-12-12 | 2022-09-14 |
| Efficacy and Safety Study of MYOBLOC in the Treatment of Sialorrhea in Pediatric Subjects MYOBLOC Low Dose, MYOBLOC High Dose, Placebo - Sialorrhea | Phase 3 | Withdrawn | Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC | 2021-11-01 | 2024-09-19 | |
| Botulinum Toxin Injection for Sialorrhea in Cerebral Palsy onaBoNT-A - Sialorrhea | Completed | Cairo University | 61 | 2021-06-30 | 2023-10-27 | |
| Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties, Placebo, Sialanar, Oral Rehabilitation - Sialorrhea, Neurodevelopmental Disorders | Phase 4 | Unknown | Proveca Pharma Limited | 80 | 2021-05-10 | 2022-07-08 |
| Post-Covid-19 Patients Follow-up Study Smell training - Smell Dysfunction, Taste Dysfunction | Not applicable | Completed | University of Oslo | 176 | 2021-04-01 | 2026-05-06 |
| Effectiveness of Kinesiotaping and Manipulation Therapies in Drooling Management Among Children With Oral Dysphagia kinesiotaping therapy, oral motor manipulation therapy - Drooling | Not applicable | Unknown | Isra University | 60 | 2020-01-01 | 2020-02-12 |
| Turkish Validation of The Drooling Impact Scale Drooling Impact Scale, Drooling Frequency and Severity Scale, The Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD™) - Hypersalivation, Cerebral Palsy | Unknown | Marmara University | 30 | 2019-11-25 | 2019-11-27 |
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Cerebral Palsy (14) · Parkinson Disease (8) · Amyotrophic Lateral Sclerosis (3) · Xerostomia (3) · Deglutition Disorders (2) · Muscle Spasticity (2) · Schizophrenia (2) · Schizophrenia, Treatment-Resistant (2) · Stroke (2) · Adenocarcinoma (1) · Anosmia (1) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Bites and Stings (1)
Mouth Diseases (57) · Salivary Gland Diseases (57) · Stomatognathic Diseases (57) · Nervous System Diseases (27) · Central Nervous System Diseases (25) · Brain Diseases (23) · Brain Damage, Chronic (14) · Neurodegenerative Diseases (10) · Pathological Conditions, Signs and Symptoms (10) · Movement Disorders (9) · Basal Ganglia Diseases (8) · Mental Disorders (8) · Parkinsonian Disorders (8) · Synucleinopathies (8) · Signs and Symptoms (7)
Botulinum Toxins, Type A (5) · rimabotulinumtoxinB (5) · Glycopyrrolate (3) · Ipratropium (3) · Sodium Chloride (2) · Transcutaneous Electric Nerve Stimulation (2) · incobotulinumtoxinA (2) · Amitriptyline (1) · Athletic Tape (1) · Atropine (1) · Baclofen (1) · Blood Specimen Collection (1) · Butylscopolammonium Bromide (1) · Clonazepam (1) · Clozapine (1)
Cairo University (4) · Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC (3) · Hacettepe University (2) · Hospices Civils de Lyon (2) · NeuroHealing Pharmaceuticals Inc. (2) · Aslinur Keles Ercisli, MD, PhD (1) · Azur Pharma, Inc (1) · Beth Israel Deaconess Medical Center (1) · Bitlis Eren University (1) · Centre Hospitalier Universitaire de Besancon (1) · Centre Hospitalier de Cadillac (1) · Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française (1) · Centre for Addiction and Mental Health (1) · Craig J. Huang (1) · Dean Nakamoto (1)
United States (12) · Turkey (Türkiye) (6) · France (5) · Egypt (4) · Canada (3) · Spain (3) · China (2) · Norway (2) · Taiwan (2) · Ukraine (2) · Argentina (1) · Belarus (1) · Germany (1) · Israel (1) · Malaysia (1)
Elkan R Gamzu, PhD (2) · Jonathan Rubin, MD (2) · Aaron L Ellenbogen, DO, MPH (1) · Adriana Rodriguez, MD (1) · Aslinur Keles Ercisli, MD, PhD (1) · Brendan Curti, MD (1) · Carlayne E Jackson, MD (1) · Charles B Simpson, MD (1) · Chi-Tai Chang, PhD (1) · Craig Huang, MD (1) · Diana Ram, DMD (1)
PMID 14718694, PMID 19758522, PMID 21565135, PMID 21636098, PMID 21887710, PMID 21932013, PMID 22298950, PMID 22527350, PMID 23698357, PMID 26579014, PMID 26787799, PMID 27871302, PMID 28183554, PMID 30061001, PMID 30963460, PMID 31236286, PMID 31860598, PMID 31930364, PMID 32149764, PMID 33151822, PMID 34721255, PMID 36538098, PMID 37370612, PMID 37833132, PMID 38492517, PMID 38708011, PMID 40498248, PMID 42237271, PMID 9843155