8 completed, 7 unknown, 4 terminated, 3 recruiting. 5 Phase 2, 4 Not applicable, 2 Phase 3, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 1, Recruiting 1, Terminated 1, Unknown 1, Withdrawn 1 |
| Not applicable | 4 | Completed 3, Recruiting 1 |
| Phase 3 | 2 | Unknown 1, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Primary Graft Dysfunction: new trials by email Literature Review of Primary Graft Dysfunction trials Research Report on Primary Graft Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Reduction Of Transplant Complications Through Enhanced Preservation Therapy to Prevent Primary Graft Dysfunction Xo Port Organ Preservation System, Standard of Care - Ice packs - Primary Graft Dysfunction | Not applicable | Recruiting | University Health Network, Toronto | 50 | 2026-04-17 | 2026-07-13 |
| This Study is Assessing the Safety and Efficacy of Immune Inhibition as a Treatment to Prevent Primary Graft Dysfunction Maraviroc, Placebo - Primary Graft Dysfunction, Lung Transplantation | Phase 2 | Recruiting | University of California, San Francisco | 120 | 2025-12-07 | 2026-01-20 |
| Perioperative Vitamin C Lung Transplant Vitamin C - Primary Graft Dysfunction, Lung Transplant; Complications | Phase 2 | Withdrawn | University of Wisconsin, Madison | 2023-04-01 | 2023-05-01 | |
| Observational Study on the Variation of Ascorbic Acid in Patients Undergoing Solid Organ Transplantation Transplantation, Ascorbic Acid Deficiency | Unknown | Policlinico Hospital | 40 | 2023-02-01 | 2024-09-04 | |
| Identifying Optimal PEEP After Lung Transplantation PEEP - Lung Transplant; Complications, Primary Graft Dysfunction | Not applicable | Completed | Policlinico Hospital | 47 | 2023-01-31 | 2025-04-02 |
| Biomolecular Phenotyping of Lung Transplant Recipients Sub-phenotyping by biomarkers concentration - Lung Transplant Failure | Completed | Policlinico Hospital | 80 | 2022-02-01 | 2025-06-18 | |
| Lung and Diaphragm Ultrasound in the Early Postoperative Course Following Lung Transplantation Ultrasound - Lung Transplantation | Not applicable | Completed | Ludwig-Maximilians - University of Munich | 70 | 2021-04-16 | 2022-06-01 |
| Primary Graft Dysfunction, Pronation, Bilateral Lung Transplants Supine positioning, Early pronation, Late pronation - Lung Transplant, Primary Graft Dysfunction | Not applicable | Completed | University of Padova | 67 | 2020-01-01 | 2024-02-01 |
| CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation blood and exhaled breath specimens - Lung Transplant Failure and Rejection, Primary Graft Dysfunction | Terminated | University Hospital, Antwerp | 24 | 2019-10-28 | 2024-05-03 | |
| Exhaled Breath Particles in Lung Transplantation Lung Transplant Rejection, Primary Graft Dysfunction | Unknown | Lund University Hospital | 150 | 2018-09-18 | 2022-05-16 | |
| Point-of-care Management of Coagulopathy in Lung Transplantation Fresh frozen plasma - Lung Transplantation | Terminated | University Hospital, Motol | 100 | 2018-01-01 | 2025-06-10 | |
| Bypass vs. Ecmo in Lung Transplantation (BELT) Extracorporeal Membrane Oxygenation, Cardiopulmonary Bypass - Lung Transplant; Complications | Terminated | The Cleveland Clinic | 13 | 2017-04-17 | 2020-03-24 | |
| Lung PGD Biomarkers in Organ Donors lung biomarkers in organ donor for PGD in lung recipient - Lung Transplant Failure | Unknown | University Hospital of Mont-Godinne | 50 | 2017-04-01 | 2017-03-24 | |
| Heart Transplant and Primary Transplant Dysfunction: a Retrospective Analysis of the Strasbourg Experience Primary Graft Dysfunction | Unknown | University Hospital, Strasbourg, France | 100 | 2017-01-01 | 2018-01-09 | |
| Measurement of Extravascular Lung Water to Detect and Predict Primary Graft Dysfunction Following Lung Transplant Primary Graft Dysfunction | Unknown | University Health Network, Toronto | 60 | 2015-10-01 | 2018-01-19 | |
| Subcutaneous Treprostinil as a Bridge to Lung Transplantation in Severe Pulmonary Hypertension: A Single-Arm Retrospective Study Subcutaneous Treprostinil - Pulmonary Hypertension, Pulmonary Arterial Hypertension | Phase 4 | Completed | Guangzhou Institute of Respiratory Disease | 46 | 2015-01-01 | 2024-09-23 |
| Pneumoproteins Expression in the Organ Donor no intervention - Primary Graft Dysfunction | Completed | University Hospital of Mont-Godinne | 20 | 2013-01-01 | 2016-03-15 | |
| Sodium Nitrite in Lung Transplant Patients to Minimize the Risk of Pulmonary Graft Dysfunction Sodium Nitrite - Primary Graft Dysfunction | Phase 2 | Terminated | Gladwin, Mark, MD | 3 | 2011-10-01 | 2018-08-01 |
| Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation EVLP Group - Disorder Related to Lung Transplantation, Brain Death | Phase 1 | Completed | Policlinico Hospital | 7 | 2011-01-01 | 2013-10-23 |
| Quantifying Physical and Biochemical Factors That Contribute to Primary Graft Dysfunction After Lung Transplantation Primary Graft Dysfunction | Unknown | University Hospital, Strasbourg, France | 45 | 2010-07-01 | 2011-03-02 |
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Heart Failure (2) · Acute Lung Injury (1) · Ascorbic Acid Deficiency (1) · Brain Death (1) · Carcinoma, Hepatocellular (1) · Hemorrhage (1) · Hemostatic Disorders (1) · Hypertension, Pulmonary (1) · Inflammation (1) · Liver Diseases (1) · Liver Failure (1) · Liver Failure, Acute (1) · Liver Neoplasms (1) · Pulmonary Arterial Hypertension (1)
Cardiovascular Diseases (25) · Pathologic Processes (25) · Pathological Conditions, Signs and Symptoms (25) · Postoperative Complications (25) · Vascular Diseases (25) · Reperfusion Injury (24) · Heart Diseases (2) · Lung Diseases (2) · Respiratory Tract Diseases (2) · Adenocarcinoma (1) · Avitaminosis (1) · Behavior (1) · Brain Diseases (1) · Carcinoma (1) · Central Nervous System Diseases (1)
Acetylcysteine (1) · Ascorbic Acid (1) · Blood Specimen Collection (1) · Cardiopulmonary Bypass (1) · Extracorporeal Membrane Oxygenation (1) · Maraviroc (1) · N-monoacetylcystine (1) · Postoperative Period (1) · Sodium Nitrite (1) · Surface-Active Agents (1) · Ultrasonography (1) · calfactant (1) · halofantrine (1) · thymoglobulin (1)
Policlinico Hospital (4) · University Health Network, Toronto (2) · University Hospital of Mont-Godinne (2) · University Hospital, Strasbourg, France (2) · University of Pennsylvania (2) · Azienda Ospedaliera di Padova (1) · Gladwin, Mark, MD (1) · Guangzhou Institute of Respiratory Disease (1) · Ludwig-Maximilians - University of Munich (1) · Lund University Hospital (1) · Rabin Medical Center (1) · The Cleveland Clinic (1) · University Hospital, Antwerp (1) · University Hospital, Motol (1) · University of California, Los Angeles (1)
Italy (6) · United States (6) · Belgium (2) · Canada (2) · France (2) · Czechia (1) · Germany (1) · Israel (1) · Sweden (1)
Jason D. Christie, MD (2) · Asmae Belhaj, MD, PhD (1) · Daniel Calabrese, MD (1) · Francesco D'Amico, MD (1) · Franco Valenza, MD (1) · Giacomo Grasselli, Porf (1) · John Granton, MD, FRCPC (1) · Julien Pottecher, MD (1) · Matthew Morrell, MD (1) · Micah Long, MD (1) · Michael Tong, M.D., M.B.A. (1) · Miroslav Durila, assoc.prof. (1) · MordechaI R Kramer, Prof (1) · Rajan Saggar, MD (1) · Sandra Lindstedt, MD, PhD (1)
PMID 22859317, PMID 23306540, PMID 24467603, PMID 24628890, PMID 27495752, PMID 32591313, PMID 33934981, PMID 36894877, PMID 37734031
R01HL081619 (1), R01HL087115 (1)