5 completed, 4 terminated. 7 Phase 2, 3 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 4, Terminated 3 |
| Phase 3 | 3 | Terminated 2, Completed 1 |
| Phase 1 | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder Nelotanserin - Lewy Body Dementia, Dementia With Lewy Bodies | Phase 2 | Terminated | Axovant Sciences Ltd. | 80 | 2016-10-20 | 2019-03-27 |
| Study Evaluating Intepirdine (RVT-101) on Gait and Balance in Subjects With Dementia RVT-101 35 mg, Placebo - Alzheimer's Disease, Dementia With Lewy Bodies | Phase 2 | Completed | Axovant Sciences Ltd. | 38 | 2016-10-01 | 2020-04-28 |
| Long-Term Extension Study of Intepirdine (RVT-101) in Subjects With Dementia With Lewy Bodies: HEADWAY-DLB Extension RVT-101 35 mg, RVT-101 70 mg - Dementia With Lewy Bodies | Phase 2 / Phase 3 | Terminated | Axovant Sciences Ltd. | 240 | 2016-10-01 | 2018-04-18 |
| 12-Month Open-Label Extension Study of Intepirdine (RVT-101) in Subjects With Alzheimer's Disease: MINDSET Extension RVT-101 35 mg tablets - Alzheimer's Disease | Phase 3 | Terminated | Axovant Sciences Ltd. | 1099 | 2016-04-26 | 2020-04-17 |
| Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD) Nelotanserin, Placebo - Dementia With Lewy Bodies, REM Sleep Behavior Disorder | Phase 2 | Completed | Axovant Sciences Ltd. | 34 | 2016-03-01 | 2020-05-20 |
| Study Evaluating Intepirdine (RVT-101) in Subjects With Dementia With Lewy Bodies: The HEADWAY-DLB Study RVT-101 35 mg, RVT-101 70 mg, Placebo - Dementia With Lewy Bodies | Phase 2 | Completed | Axovant Sciences Ltd. | 484 | 2016-01-01 | 2019-04-26 |
| Study Evaluating Nelotanserin for Treatment of Visual Hallucinations in Subjects With Lewy Body Dementia Nelotanserin, Placebo - Lewy Body Dementia, Visual Hallucinations | Phase 2 | Completed | Axovant Sciences Ltd. | 30 | 2015-12-01 | 2018-01-18 |
| Study Evaluating Intepirdine (RVT-101) in Subjects With Mild to Moderate Alzheimer's Disease on Donepezil: MINDSET Study RVT-101, Placebo - Alzheimer's Disease | Phase 3 | Completed | Axovant Sciences Ltd. | 1315 | 2015-10-01 | 2018-12-05 |
| Long Term Safety and Efficacy Study of ProSavin in Parkinson's Disease ProSavin - Parkinson's Disease | Phase 1 / Phase 2 | Terminated | Axovant Sciences Ltd. | 15 | 2011-05-01 | 2022-05-03 |
Lewy Body Disease (6) · Alzheimer Disease (3) · Dementia (3) · Hallucinations (2) · REM Sleep Behavior Disorder (2) · Parkinson Disease (1)
3-benzenesulfonyl-8-piperazin-1-ylquinoline (5) · nelotanserin (3)
United States (8) · France (5) · United Kingdom (5) · Canada (4) · Italy (4) · Spain (4) · Argentina (2) · Australia (2) · Bulgaria (2) · Chile (2) · Croatia (2) · Czechia (2) · Germany (2) · Netherlands (2) · Poland (2)
Ilise Lombardo, MD (8) · Roger Barker, Dr (1) · Stephane Palfi, Professor (1)
2009 (1)