13 recruiting, 5 completed, 4 unknown, 3 terminated. 29 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 29 | Recruiting 13, Completed 5, Unknown 4, Terminated 3, Not yet recruiting 2, Active not recruiting 1, Suspended 1 |
Follow REM Sleep Behavior Disorder: new trials by email Literature Review of REM Sleep Behavior Disorder trials Research Report on REM Sleep Behavior Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns., Sham (No Treatment) - Nightmare, Insomnia | Not applicable | Not yet recruiting | Uniformed Services University of the Health Sciences | 180 | 2026-06-01 | 2026-04-28 |
| Understanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and Neuroimaging brain imaging, blood draw, Skin biopsy - Parkinson's Disease (PD), GBA1 Parkinson Disease | Not applicable | Not yet recruiting | University of Pavia | 160 | 2026-05-11 | 2026-05-01 |
| PET-MRI of Reward System in Parkinson's Disease With RBD PET-MRI (Positron Emission Tomography - Magnetic Resonance Imaging). - Parkinson's Disease (PD) | Not applicable | Recruiting | University Hospital, Clermont-Ferrand | 44 | 2026-05-07 | 2026-07-08 |
| L-THEANINE AND MEDITERRANEAN DIET ON RBD, GI FUNCTION, AND INFLAMMATION IN PARKINSON'S DISEASE Dietary Supplement, Control group (placebo) - Parkinson Disease (PD) | Not applicable | Recruiting | Medipol University | 52 | 2026-05-02 | 2026-07-06 |
| Pain Assessment in Patients With Idiopathic Rapid Eye Movement (REM) Sleep Behaviour Disorder Thermo test pain, Pain questionnaires, No motors symptoms evaluations - REM Sleep Behavior Disorder (iRBD), Narcolepsy Type 1 | Not applicable | Recruiting | University Hospital, Toulouse | 24 | 2026-02-24 | 2026-05-01 |
| Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1 - Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 300 | 2026-02-13 | 2026-04-03 |
| Role of Slow Waves in the Progression of Neurodegeneration in Isolated REM Sleep Behavior Disorder Tosoo Axora - Parkinson Disease, REM Sleep Behavior Disorder (iRBD) | Not applicable | Recruiting | University of Zurich | 80 | 2026-01-15 | 2026-02-17 |
| Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease Ginger - REM Sleep Behavior Disorder, Parkinson s Disease | Not applicable | Recruiting | Cambridge University Hospitals NHS Foundation Trust | 72 | 2025-12-17 | 2026-10-21 |
| Development and Online Evaluation of an Online Course for Parasomnias Parasomnia Education, Sleep Hygiene Control - Sleep Terror, Sleepwalking | Not applicable | Recruiting | University of Manitoba | 20 | 2025-11-14 | 2026-01-23 |
| The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions Probiotic Supplementation with L. reuteri - PARKINSON DISEASE (Disorder), Parkinson | Not applicable | Recruiting | University of Cambridge | 215 | 2025-11-01 | 2026-08-25 |
| Study of Sleep Disorders in Prodromal and Definite Parkinsons Disease Polysomnography - Parkinson Disease, REM Sleep Behavior Disorder (iRBD) | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 457 | 2025-03-18 | 2026-03-06 |
| The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders Transcranial Magnetic Stimulation - Insomnia Chronic, Narcolepsy | Not applicable | Recruiting | Second Affiliated Hospital of Soochow University | 20 | 2025-02-01 | 2025-02-14 |
| Artificial Intelligence in Molecular Imaging: Predicting Parkinson's Risk in REM Sleep Behavior Disorder PET/CT with 18-FDG, SPECT : 123 I-FP-CIT (DATSCAN), MRI - Parkinson Disease, REM Sleep Behavior Disorder | Not applicable | Recruiting | Insel Gruppe AG, University Hospital Bern | 20 | 2024-10-07 | 2024-11-08 |
| Effect of Acupuncture for Rapid Eye Movement Sleep Behavior Disorder Acupuncture group, Sham acupuncture group - Rapid Eye Movement Sleep Behavior Disorder | Not applicable | Unknown | Beijing Hospital of Traditional Chinese Medicine | 30 | 2024-09-25 | 2024-09-23 |
| Behavioral Treatment for Nightmares in REM Sleep Behavior Disorder Cognitive Behavioral Therapy for Nightmares - Nightmare, Nightmare Disorder With Associated Other Sleep Disorder | Not applicable | Recruiting | University of Utah | 20 | 2024-07-15 | 2026-03-12 |
| 5-HT RBD REM Sleep Behavior Disorder Skin biopsy, Speech testing, Ultra high field 7T MRI - Dementia With Lewy Bodies, Parkinson Disease | Not applicable | Active not recruiting | University of Minnesota | 66 | 2024-02-08 | 2026-08-10 |
| Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands Increase of physical activity volume and intensity with the use of a motivational smartphone application - Parkinson Disease, Prodromal Stage | Not applicable | Recruiting | Radboud University Medical Center | 110 | 2024-01-15 | 2026-08-27 |
| Microstructural and Sodium 7 Tesla Brain MRI in Idiopathic REM Sleep Behaviour Disorder 7T MRI - REM Sleep Behaviour Disorder | Not applicable | Completed | Assistance Publique Hopitaux De Marseille | 31 | 2023-10-30 | 2026-01-21 |
| Extended-Release Melatonin in Patients With Rapid Eye Movement Sleep Behavior Disorder Immediate Release Melatonin, Extended Release Melatonin - Rapid Eye Movement Sleep Behavior Disorder, Parkinson Disease | Not applicable | Terminated | Mayo Clinic | 25 | 2022-05-01 | 2024-05-29 |
| Effects of Tablet Computer-based Cognitive Training in Patients With Idiopathic REM Sleep Behavior Disorder Tablet computer-based cognitive training program - REM Sleep Behavior Disorder | Not applicable | Suspended | Seoul National University Hospital | 60 | 2022-02-07 | 2023-04-21 |
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Parkinson Disease (19) · Lewy Body Disease (5) · Alzheimer Disease (2) · Dementia (2) · Inflammation (2) · Narcolepsy (2) · Parkinsonian Disorders (2) · Sleep Initiation and Maintenance Disorders (2) · Synucleinopathies (2) · Amyotrophic Lateral Sclerosis (1) · Basal Ganglia Diseases (1) · Brain Diseases (1) · Cataplexy (1) · Central Nervous System Diseases (1)
Mental Disorders (29) · Parasomnias (29) · REM Sleep Parasomnias (29) · Nervous System Diseases (28) · Sleep Wake Disorders (28) · Movement Disorders (19) · Basal Ganglia Diseases (18) · Brain Diseases (18) · Central Nervous System Diseases (18) · Neurodegenerative Diseases (18) · Parkinsonian Disorders (17) · Synucleinopathies (17) · Pathological Conditions, Signs and Symptoms (9) · Neurocognitive Disorders (6) · Signs and Symptoms (6)
Blood Specimen Collection (2) · Biological Factors (1) · Clonazepam (1) · Cognitive Behavioral Therapy (1) · Control Groups (1) · Defecation (1) · Dietary Supplements (1) · Magnetic Resonance Imaging (1) · Melatonin (1) · Neuroimaging (1) · Phototherapy (1) · Positron Emission Tomography Computed Tomography (1) · Spectroscopy, Near-Infrared (1) · Surveys and Questionnaires (1) · Transcranial Direct Current Stimulation (1)
University Hospital, Clermont-Ferrand (4) · Seoul National University Hospital (2) · Assistance Publique - Hôpitaux de Paris (1) · Assistance Publique Hopitaux De Marseille (1) · Beijing Hospital of Traditional Chinese Medicine (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Clinique Beau Soleil (1) · Czech Technical University in Prague (1) · Insel Gruppe AG, University Hospital Bern (1) · Kyung Hee University Hospital at Gangdong (1) · Mayo Clinic (1) · Medipol University (1) · Northwestern University (1) · Radboud University Medical Center (1) · Second Affiliated Hospital of Soochow University (1)
France (10) · United States (6) · South Korea (3) · Canada (2) · Italy (2) · Switzerland (2) · United Kingdom (2) · Austria (1) · Belgium (1) · China (1) · Czechia (1) · Germany (1) · Netherlands (1) · Turkey (Türkiye) (1)
Aleksandar Videnovic, M.D. (1) · Andreas Luft, Prof. Dr. med. (1) · Caroline H. Williams-Gray, BMBCh FRCP PhD (1) · Caroline Williams-Gray, Dr. (1) · Emir Festic, MD, MS (1) · Francois Cremieux (1) · Huanqin Li, Physician (1) · Jan Rusz, PhD (1) · Jee-Young Lee, MD, PhD (1) · Ki-Young Jung, professor (1) · Kuanggyu Shi, Prof. Dr. ing. (1)
PMID 35141811, PMID 41688680, PMID 42448717
2023 (1)