50 completed, 30 recruiting, 14 unknown, 6 terminated. 42 Not applicable, 16 Phase 2, 7 Phase 1, 5 Phase 3.
Follow Charcot-Marie-Tooth Disease: new trials by email Literature Review of Charcot-Marie-Tooth Disease trials Research Report on Charcot-Marie-Tooth Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase I/IIa Trial of scAAV1.tMCK.NTF3 for Treatment of CMT1A scAAV1.tMCK.NTF3 - Charcot-Marie-Tooth Neuropathy Type 1A | Phase 1 / Phase 2 | Withdrawn | Nationwide Children's Hospital | 2027-04-01 | 2026-07-29 | |
| Muscle MRI Fat Fraction Before Surgery to Predict Strength Recovery After Foot-Drop Surgery in Charcot-Marie-Tooth Disease Tibialis posterior tendon transfer, Individualized adjunct procedures for cavovarus deformity correction, Ankle-foot orthosis (AFO) - Foot Drop, Charcot-Marie-Tooth Disease Type 1A | Not yet recruiting | Peking University Third Hospital | 100 | 2026-12-01 | 2026-10-26 | |
| Clinical, Electrophysiological and Genetic Characteristics of Hereditary and Inflammatory Polyneuropathies in France Genetic and Inflammatory Polyneuropathies | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1000 | 2026-11-01 | 2026-10-01 | |
| Genotype/Phenotype Correlation of MORC2 Mutations Skin biopsy, Blood sample - Charcot Marie Tooth Disease, DIFGAN | Recruiting | Hospices Civils de Lyon | 45 | 2026-06-16 | 2026-06-18 | |
| Physical Activity Level at Home in CMT1A Patients: Wearable Sensor Assessment Charcot-Marie-Tooth Disease, Type IA, Peripheral Neuropathy Hereditary | Not yet recruiting | University Hospital, Limoges | 60 | 2026-06-01 | 2026-05-22 | |
| Ultrasound-Guided Nerve Hydrodissection for Diabetic Lower Limb Entrapment Neuropathy Ultrasound-guided nerve hydrodissection treatment, Sham treatment - Diabetic Peripheral Neuropathy, Entrapment Neuropathy | Not applicable | Recruiting | Chongqing Medical University | 266 | 2026-05-20 | 2026-06-17 |
| Kinesio Taping for Pain, Median Nerve Morphology, and Quality of Life in Patients With Carpal Tunnel Syndrome Kinesio Taping, Nerve and Tendon Gliding Exercises - Carpal Tunnel Syndrome, Median Nerve Compression | Not applicable | Completed | Istanbul Gelisim University | 40 | 2026-05-10 | 2026-08-03 |
| Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease Whole-body Electrical Muscle Stimulation Exercise - Neuromuscular Diseases (NMD), Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | University of Missouri-Columbia | 50 | 2026-03-10 | 2026-03-17 |
| Assessment of a Portable Digital Device for Quantified Analysis of Markerless Walking in Volunteers With Neuromuscular Diseases or Asymptomatic Volunteers Gait analysis via video capture - Spinal Muscular Atrophy (SMA), Charcot-Marie-Tooth | Not applicable | Recruiting | Institut de Myologie, France | 30 | 2026-03-03 | 2026-05-19 |
| The Effectiveness of Low-Level Laser Therapy in the Treatment of Meralgia Paresthetica Transcutaneous Electrical Nerve Stimulation (TENS), Low-Level Laser Therapy - Meralgia Paresthetica, Lateral Femoral Cutaneous Nerve Entrapment | Not applicable | Completed | Istanbul Training and Research Hospital | 36 | 2026-03-02 | 2026-07-08 |
| Walking Function Outcomes Following Surgical Correction With Rehabilitation Versus Physical Therapy Alone in Charcot-Marie-Tooth Disease: A Bidirectional Cohort Study Functional Surgery plus Rehabilitation, Physical Exercise - Charcot Marie Tooth Disease (CMT), Pes Cavovarus | Not yet recruiting | Peking University Third Hospital | 200 | 2026-02-11 | 2026-02-25 | |
| High-Intensity Laser Therapy in Carpal Tunnel Syndrome: Clinical, Sonographic, and Electrophysiological Outcomes High-Intensity Laser Therapy (HILT), Sham High-Intensity Laser Therapy - Carpal Tunnel Syndrome | Not applicable | Recruiting | Ankara City Hospital Bilkent | 80 | 2025-11-02 | 2026-02-17 |
| A First in Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of EDK060 in Adults With CMT1A. EDK060, dose A, EDK060, dose B, EDK060, dose C - Charcot-Marie-Tooth Disease, Type 1A | Phase 1 | Recruiting | Novartis Pharmaceuticals | 28 | 2025-09-30 | 2026-07-29 |
| Effects of Resistance Exercises in Hereditary Sensory-Motor Neuropathy (Charcot-Marie-Tooth Disease) Progressive Resistance Exercise Training - Polyneuropathy, Charcot Marie Tooth Disease (CMT) | Not applicable | Recruiting | Universidad de La Frontera | 22 | 2025-09-20 | 2025-09-23 |
| CMT Gait, Mobility, Balance - AOFAS Grant Ankle-foot Orthoses - Charcot Marie Tooth Disease (CMT) | Not applicable | Recruiting | Bopha Chrea | 66 | 2025-08-14 | 2025-09-23 |
| "Ultrasound Measures and Clinical Outcomes in Healthy Individuals, Mild and Moderate Carpal Tunnel Syndrome Patients" ultrasound - Carpal Tunnel Syndrome (CTS), Median Nerve Entrapment | Completed | Istanbul University | 75 | 2025-07-25 | 2026-02-13 | |
| Topical Cannabidiol for Treating Carpal Tunnel Syndrome Cannabidiol - Carpal Tunnel Syndrome | Phase 2 | Not yet recruiting | University of Virginia | 20 | 2025-07-01 | 2025-04-11 |
| Identification of Novel Biomarkers in Early Charcot-Marie-Tooth 1A Disease Quantitative neuromuscular MRI, Skin biopsy, Clinical scores - Charcot-Marie-Tooth Disease Type 1A | Not applicable | Active not recruiting | Assistance Publique Hopitaux De Marseille | 55 | 2025-06-24 | 2026-10-28 |
| Longitudinal Quantitative Neuromuscular MRI in Neuropathic Patients Quantitative neuromuscular MRI, Neuromuscular ultrasound - Charcot-Marie-Tooth Neuropathy Type 1A, Hereditary Transthyretin Amyloid Neuropathy | Not applicable | Recruiting | Assistance Publique Hopitaux De Marseille | 120 | 2025-05-23 | 2026-10-29 |
| Treatment of Charcot-Marie-Tooth Disease, Axonal, Type 2S (CMT2S) in an Individual Patient VCA-894A - Charcot Marie Tooth Disease (CMT), Neuromuscular Diseases (NMD) | Phase 1 / Phase 2 | Active not recruiting | Vanda Pharmaceuticals | 1 | 2025-05-13 | 2026-08-19 |
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Neuromuscular Diseases (11) · Carpal Tunnel Syndrome (10) · Peripheral Nervous System Diseases (9) · Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (9) · Hereditary Sensory and Motor Neuropathy (7) · Median Neuropathy (6) · Amyotrophic Lateral Sclerosis (5) · Muscular Atrophy, Spinal (5) · Muscular Dystrophy, Facioscapulohumeral (5) · Muscular Dystrophies (4) · Myotonic Dystrophy (4) · Nerve Compression Syndromes (4) · Polyneuropathies (4) · Refsum Disease (4)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (112) · Congenital Abnormalities (111) · Heredodegenerative Disorders, Nervous System (111) · Nervous System Malformations (111) · Neurodegenerative Diseases (111) · Genetic Diseases, Inborn (110) · Nervous System Diseases (110) · Polyneuropathies (108) · Hereditary Sensory and Motor Neuropathy (105) · Peripheral Nervous System Diseases (103) · Neuromuscular Diseases (101) · Pathological Conditions, Signs and Symptoms (30) · Central Nervous System Diseases (17) · Pathologic Processes (17) · Immune System Diseases (16)
Exercise (3) · Ascorbic Acid (2) · Hematologic Tests (2) · Rehabilitation (2) · Transcutaneous Electric Nerve Stimulation (2) · Biotin (1) · Blood Specimen Collection (1) · Cannabidiol (1) · Disease Vectors (1) · Glucose (1) · Long-Term Synaptic Depression (1) · Low-Level Light Therapy (1) · Mexiletine (1) · Naltrexone (1) · Radiofrequency Ablation (1)
University Medical Center Goettingen (5) · Pharnext S.C.A. (4) · University of Iowa (4) · Ankara City Hospital Bilkent (3) · Assistance Publique Hopitaux De Marseille (3) · Centre Hospitalier Universitaire de Liege (3) · Peking University Third Hospital (3) · University Hospital, Clermont-Ferrand (3) · Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA (2) · Assistance Publique - Hôpitaux de Paris (2) · Centre Hospitalier Universitaire de Nice (2) · Children's Hospital of Philadelphia (2) · ENCell (2) · Istanbul University - Cerrahpasa (2) · Maxima Medical Center (2)
United States (40) · France (22) · United Kingdom (11) · Italy (10) · Canada (9) · Turkey (Türkiye) (9) · Belgium (7) · Germany (7) · Netherlands (5) · Spain (5) · Australia (4) · Denmark (4) · South Korea (4) · China (3) · Cyprus (2)
Michael E Shy, MD (4) · Adeline Vanderver, MD (2) · David Herrmann, MBBCh (2) · Mark Roberts, MD (2) · Rudi Roumen, MD, PhD (2) · Shahram Attarian, MD (2) · Teresa Sevilla, MD (2) · Zarife Sahenk, MD., PhD. (2) · Aftab Ahmed Mirza Baig, DPT,MSAPT (1) · Allison Moore (1) · Angelo E Schenone, MD (1) · Berna Orhan, MD (1)
PMID 25519680, PMID 37395948, PMID 10411196, PMID 11232233, PMID 11382253, PMID 12235608, PMID 12671856, PMID 12851579, PMID 14564276, PMID 15610704, PMID 15680560, PMID 1577335, PMID 17210425, PMID 17986401, PMID 18312102, PMID 18455840, PMID 18843618, PMID 19084178, PMID 19181226, PMID 19457636, PMID 19479509, PMID 19703733, PMID 19774309, PMID 19782873, PMID 19909499, PMID 20595866, PMID 20850975, PMID 21254193, PMID 21694556, PMID 22475878, PMID 23182641, PMID 23797954, PMID 23806957, PMID 24090983, PMID 25286435, PMID 25430934, PMID 25491744, PMID 25546691, PMID 26070802, PMID 26142079, PMID 26183690, PMID 26247043, PMID 27124017, PMID 27387831, PMID 27469410, PMID 27876086, PMID 28284873, PMID 28394089, PMID 28484650, PMID 28768847
U54NS065712 (4), 2015 (2), 2025 (1), R01HD113778 (1), U01NS106845 (1), U01TR001263 (1), U54NS064808 (1), U54NS115052 (1)