3 unknown, 2 completed, 2 terminated, 2 withdrawn. 10 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 10 | Unknown 3, Completed 2, Terminated 2, Withdrawn 2, Recruiting 1 |
| Phase 2 | 4 | Completed 2, Unknown 1, Withdrawn 1 |
Follow Reflex Sympathetic Dystrophy: new trials by email Literature Review of Reflex Sympathetic Dystrophy trials Research Report on Reflex Sympathetic Dystrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE) Neridronate, Placebo - Complex Regional Pain Syndrome Type I | Phase 3 | Recruiting | Ambros Therapeutics, Inc. | 270 | 2026-04-14 | 2026-10-29 |
| Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Neridronic acid 100 mg, Placebo - Complex Regional Pain Syndrome (CRPS) | Phase 3 | Terminated | Grünenthal GmbH | 267 | 2018-05-31 | 2020-08-05 |
| Efficacy and Safety of Intravenous Neridronic Acid in CRPS Neridronic acid 100 mg, Placebo - Complex Regional Pain Syndrome (CRPS) | Phase 3 | Terminated | Grünenthal GmbH | 182 | 2018-05-30 | 2020-08-06 |
| CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1 AXS-02 (oral zoledronate), Placebo - Complex Regional Pain Syndrome, Reflex Sympathetic Dystrophy | Phase 3 | Unknown | Axsome Therapeutics, Inc. | 190 | 2015-07-01 | 2018-03-23 |
| Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Placebo, Neridronic acid 62.5 mg - Complex Regional Pain Syndrome, Type I | Phase 2 / Phase 3 | Completed | Grünenthal GmbH | 459 | 2015-04-01 | 2018-05-09 |
| Acupuncture for Post-stroke Shoulder-hand Syndrome rehabilitation, Acupuncture - Shoulder-hand Syndrome | Phase 2 / Phase 3 | Unknown | Zouqin Huang | 90 | 2013-10-01 | 2013-12-13 |
| Intravenous Immunoglobulins in Complex-regional Pain Syndrome intravenous immunoglobulins - Complex Regional Pain Syndrome Type 1 | Phase 3 | Withdrawn | University of Giessen | 2009-08-01 | 2021-07-15 | |
| Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) SUBCUTANEOUS VENOUS SYMPATHECTOMY (RSVS) - CRPS Type II | Phase 3 | Unknown | Medical University of Vienna | 20 | 2009-01-01 | 2011-07-12 |
| Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1) PEPT, CBO standard - Complex Regional Pain Syndrome, Type I | Phase 2 / Phase 3 | Completed | Radboud University Medical Center | 62 | 2009-01-01 | 2013-07-24 |
| Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception laboratory pain assessment, transcranial magnetic stimulation - Pain, Trigeminal Neuralgia | Phase 2 / Phase 3 | Withdrawn | Medical University of South Carolina | 2006-07-01 | 2012-04-30 |
Complex Regional Pain Syndromes (7) · Pain (3) · Chronic Pain (2) · Autoimmune Diseases (1) · Causalgia (1) · Edema (1) · Neuralgia (1) · Trigeminal Neuralgia (1)
Autonomic Nervous System Diseases (10) · Nervous System Diseases (10) · Neuromuscular Diseases (10) · Peripheral Nervous System Diseases (10) · Neurologic Manifestations (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Complex Regional Pain Syndromes (3) · Cranial Nerve Diseases (1) · Facial Nerve Diseases (1) · Facial Neuralgia (1) · Immune System Diseases (1) · Mouth Diseases (1) · Neuralgia (1) · Pain (1)
6-amino-1-hydroxyhexane-1,1-diphosphonate (4) · 1,10-phenanthroline-platinum(II)-ethylenediamine (1) · Acupuncture Therapy (1) · Immunoglobulins, Intravenous (1) · Rehabilitation (1) · Transcranial Magnetic Stimulation (1) · Zoledronic Acid (1)
Grünenthal GmbH (3) · Ambros Therapeutics, Inc. (1) · Axsome Therapeutics, Inc. (1) · Medical University of South Carolina (1) · Medical University of Vienna (1) · Radboud University Medical Center (1) · University of Giessen (1) · Zouqin Huang (1)
United States (6) · Germany (3) · United Kingdom (3) · Australia (2) · Canada (2) · Austria (1) · China (1) · Czechia (1) · France (1) · Netherlands (1) · New Zealand (1) · Poland (1) · Serbia (1) · Slovakia (1) · South Korea (1)
Huang Zouqin, Dcctor (1) · Jeffrey J. Borckardt, Ph.D. (1) · Wolfgang Happak, Prof. MD (1)
PMID 22515496, PMID 25919011, PMID 26628523
2014 (1), 2016 (1), 2017 (1), K23NS050485 (1)