23 completed, 7 recruiting, 5 unknown, 2 not yet recruiting. 17 Not applicable, 7 Phase 4, 6 Phase 2, 5 Phase 3, 2 Phase 1.
Follow Premenstrual Dysphoric Disorder: new trials by email Literature Review of Premenstrual Dysphoric Disorder trials Research Report on Premenstrual Dysphoric Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The SPARK-PMDD Study Premenstrual Dysphoric Disorder, PMDD | Not yet recruiting | King's College London | 120 | 2027-01-01 | 2026-08-18 | |
| MLS101 Study in PMDD MLS101 psilocybin, Placebo capsules - Premenstrual Dysphoric Disorder ( PMDD), PMDD | Phase 1 | Not yet recruiting | MycoMedica Life Sciences PBC | 32 | 2026-12-01 | 2026-09-14 |
| Transcutaneous Auricular Neurostimulation (tAN) for Premenstrual Dysphoric Disorder (PMDD) and Perimenopause transcutaneous auricular neurostimulation (tAN) - Perimenopause, PMDD | Not applicable | Enrolling by invitation | Texas Christian University | 20 | 2026-10-22 | 2026-10-23 |
| CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life Lutea Transcranial Direct Current Stimulation (tDCS) Device, Samphire Guided Care Program - Premenstrual Syndrome, Premenstrual Dysphoric Disorder | Recruiting | Samphire Group, Inc. | 50 | 2026-06-01 | 2026-07-01 | |
| To Establish Whether Individuals With Premenstrual Dysphoric Disorder (PMDD) Demonstrate a Different Luteal-phase Sex Hormone Profile and Ratio Compared With Asymptomatic Controls. Premenstrual Dysphoric Disorder ( PMDD) | Recruiting | Lancaster University | 50 | 2026-05-05 | 2026-07-07 | |
| Occupational Physicians Facing Premenstrual Dysphoric Disorder: Knowledge, Perceptions and Practices in Occupational Health Premenstrual Dysphoric Disorder (PMDD) | Recruiting | University Hospital, Strasbourg, France | 15 | 2026-03-09 | 2026-10-07 | |
| Identification and Validation of Epigenetic Biomarkers of PMDD PMDD, Premenstrual Dysphoric Disorder (PMDD) | Recruiting | Johns Hopkins University | 500 | 2025-09-12 | 2026-05-07 | |
| Emotion Regulation-based Internet-delivered Cognitive Behavioural Therapy for Premenstrual Dysphoric Disorder Therapist-guided internet-delivered cognitive behavioural therapy - Premenstrual Dysphoric Disorder | Not applicable | Recruiting | Uppsala University | 164 | 2025-07-14 | 2025-07-31 |
| Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder sertraline 50 mg daily, Placebo Oral Tablet - Premenstrual Dysphoric Disorder (PMDD) | Phase 4 | Recruiting | Johns Hopkins University | 288 | 2025-05-14 | 2026-05-07 |
| The Effect of Progressive Muscle Relaxation Exercises on Premenstrual Syndrome, Anxiety, and Tendency to Violence in Young Women Exercise - Premenstrual Disorder | Not applicable | Completed | Istanbul Medipol University Hospital | 84 | 2025-04-01 | 2026-10-01 |
| Adapting and Piloting Acceptance and Commitment Therapy (ACT) for Severe Premenstrual Mood Symptoms Acceptance and Commitment Therapy (ACT) Group - Premenstrual Dysphoric Disorder, Premenstrual Exacerbation of Mood Disorder | Not applicable | Active not recruiting | Women's College Hospital | 50 | 2024-12-01 | 2025-12-22 |
| Pilot Study of the 'Thriving With PMDs' Program Self-directed psychotherapy program for premenstrual disorders - Premenstrual Disorder, Premenstrual Dysphoric Disorder | Not applicable | Recruiting | University of Regina | 50 | 2024-10-15 | 2025-04-06 |
| Kinesio Taping vs Tele-Pilates for PMS Tele- pilates, Kinesio taping application for the KT group - Premenstrual Disorder | Not applicable | Completed | Cairo University | 90 | 2024-01-01 | 2025-07-14 |
| The Effects of Mixhers HERTIME Supplements on Menstrual Symptoms Mixhers HERTIME, Placebo - Healthy, Premenstrual Dysphoric Disorder | Not applicable | Completed | Midwestern University | 100 | 2023-08-30 | 2024-05-08 |
| Combined Effect of Tryptophan Rich Diet and Acupuncture on Depression Related to Premenstrual Dysphoric Disorder Acupuncture, Tryptophan-Rich Diet, Vitamin B6 Supplementation - Premenstrual Dysphoric Disorder | Not applicable | Unknown | Cairo University | 39 | 2023-04-25 | 2023-04-14 |
| Oral Contraceptives for Treating Premenstrual Dysphoric Disorder in Bipolar Disorder Yaz, Placebo - Premenstrual Dysphoric Disorder, Bipolar Disorder | Phase 2 | Completed | St. Joseph's Healthcare Hamilton | 17 | 2023-02-03 | 2024-09-23 |
| Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25 Cramp Bites by Aunt Flo's Kitchen - Dysmenorrhea Primary, Dysmenorrhea | Phase 2 / Phase 3 | Completed | Cornell University | 12 | 2022-07-21 | 2024-04-12 |
| Premenstrual Dysphoric Disorder:Knowledge,Attitude and Practice Among Egyptian Females questionnaire - Premenstrual Dysphoric Disorder | Unknown | Al-Azhar University | 150 | 2022-03-15 | 2022-07-21 | |
| EnBrace HR for PMS With Prominent Mood Symptoms or Menstrual Related Mood Disorders EnBrace HR Softgel - Premenstrual Syndrome, Premenstrual Dysphoric Disorder | Phase 4 | Withdrawn | Massachusetts General Hospital | 2019-11-01 | 2020-01-02 | |
| Premenstrual Hormonal and Affective State Evaluation (PHASE) Project Individualized laboratory test - Premenstrual Dysphoric Disorder | Not applicable | Completed | University of Illinois at Chicago | 129 | 2019-09-26 | 2025-04-24 |
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Premenstrual Syndrome (16) · Depression (4) · Depressive Disorder, Major (2) · Dysmenorrhea (2) · Menstruation Disturbances (2) · Acne Vulgaris (1) · Bipolar Disorder (1) · Cyclothymic Disorder (1) · Dysthymic Disorder (1) · Emotional Regulation (1) · Endometriosis (1) · Inflammation (1) · Mental Fatigue (1) · Muscle Cramp (1)
Depressive Disorder (42) · Mental Disorders (42) · Mood Disorders (42) · Pathologic Processes (42) · Pathological Conditions, Signs and Symptoms (42) · Menstruation Disturbances (40) · Premenstrual Syndrome (26) · Behavior (6) · Behavioral Symptoms (5) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Genital Diseases (2) · Genital Diseases, Female (2) · Neurologic Manifestations (2) · Pain (2)
drospirenone and ethinyl estradiol combination (4) · Paroxetine (2) · Sertraline (2) · Acupuncture Therapy (1) · Bone Remodeling (1) · Ethinyl Estradiol (1) · Exercise (1) · Fluoxetine (1) · Flutamide (1) · Levetiracetam (1) · Oxytocin (1) · Population Groups (1) · Pregnanolone (1) · Spectrometry, Fluorescence (1) · Sugars (1)
University of North Carolina, Chapel Hill (4) · Bayer (2) · Cairo University (2) · Johns Hopkins University (2) · Tel-Aviv Sourasky Medical Center (2) · Weill Medical College of Cornell University (2) · Al-Azhar University (1) · Asarina Pharma (1) · Berkshire Health Systems (1) · Cornell University (1) · Hamilton Health Sciences Corporation (1) · Istanbul Medipol University Hospital (1) · Karolinska Institutet (1) · King's College London (1) · Lancaster University (1)
United States (19) · Canada (4) · Sweden (4) · United Kingdom (3) · Egypt (2) · Germany (2) · China (1) · France (1) · Israel (1) · Poland (1) · South Korea (1) · Turkey (Türkiye) (1)
Margaret Altemus, MD (2) · Ajna Hamidovic, PharmD, MS (1) · Asmaa M. Elbandrawy, Professor (1) · Barbara L Parry, M.D. (1) · Benicio N Frey, MD, MSc,PhD (1) · Carolyn Janda, Ph.D.Student (1) · Chris Gaffney, BSc (Hons.) MSc PhD SFHEA (1) · Cornelia Weise, Ph.D. (1) · Cynthia N Epperson, MD (1) · David R Rubinow, MD (1) · Ellen W Freeman, PhD (1) · Farshad Agahi, MD (1) · Flavio Frohlich, PhD (1)
PMID 18517289, PMID 22393222, PMID 25467540, PMID 26351969, PMID 28715852, PMID 36520251, PMID 37212651, PMID 37365881, PMID 38664491, PMID 42338742
2023 (1), R01MH072955 (1), R01MH081837 (1), R01MH101547 (1), R01MH134904 (1), R01MH135896 (1), R21MH119642 (1), R34MH072878 (1)