52 completed, 14 unknown, 6 terminated, 1 not yet recruiting. 21 Phase 3, 17 Phase 4, 15 Phase 1, 9 Not applicable, 9 Phase 2.
Follow drospirenone and ethinyl estradiol combination: new trials by email Literature Review of drospirenone and ethinyl estradiol combination trials Research Report on drospirenone and ethinyl estradiol combination
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Drospirenone-Primed Ovarian Stimulation Versus GnRH Antagonist Protocol in Poor Ovarian Responders Undergoing Freeze-All IVF/ICSI Drospirenone drug, Cetrorelix 0.25 mg - Poor Ovarian Reserve, Infertility (IVF Patients) | Phase 1 / Phase 2 | Not yet recruiting | Ahmed Saad | 100 | 2026-08-01 | 2026-07-30 |
| A Study in Japanese Healthy Men to Test How Well Different Doses of BI 3031185 Are Tolerated and a Study in Japanese Healthy Women to Test Whether BI 3031185 Influences the Amount of a Contraceptive in the Blood BI 3031185, Placebo matching BI 3031185, Midazolam - Healthy | Phase 1 | Terminated | Boehringer Ingelheim | 8 | 2026-07-17 | 2026-10-06 |
| Can Drospirenone be Used to Prevent LH Surge in Controlled Ovarian Stimulation in PCOS?! Cetrorelix drug, Drospirenone drug - PCOS (Polycystic Ovary Syndrome) | Phase 1 / Phase 2 | Completed | Ahmed Saad | 50 | 2024-10-01 | 2025-01-22 |
| Effect of Drospirenone-Ethinyl Estradiol (20microgram vs 30 Microgram) on Free Androgen Index in PCOS Drospirenone Ethinyl Estradiol (20 microgram), Drospirenone Ethinyl Estradiol (30 microgram) - PCOS (Polycystic Ovary Syndrome) | Not applicable | Completed | Mst.Sumyara Khatun | 60 | 2024-07-01 | 2026-01-09 |
| Role of Medical Treatment in Endometriosis Patients Undergoing ICSI Combined contraceptive pills (Yasmin) - Endometriosis | Not applicable | Unknown | Cairo University | 129 | 2024-07-01 | 2024-08-29 |
| A Study in Healthy Women to Test Whether BI 1358894 Influences the Amount of a Contraceptive in the Blood Yasmin®, BI 1358894 - Healthy | Phase 1 | Terminated | Boehringer Ingelheim | 29 | 2023-09-08 | 2025-02-24 |
| A Study to Investigate the Effects of BMS-986278 on Drospirenone and Ethinyl Estradiol Drug Levels in Healthy Female Participants BMS-986278, Drospirenone/Ethinyl Estradiol - Healthy Volunteers | Phase 1 | Completed | Bristol-Myers Squibb | 37 | 2023-08-18 | 2024-01-24 |
| Oral Contraceptives for Treating Premenstrual Dysphoric Disorder in Bipolar Disorder Yaz, Placebo - Premenstrual Dysphoric Disorder, Bipolar Disorder | Phase 2 | Completed | St. Joseph's Healthcare Hamilton | 17 | 2023-02-03 | 2024-09-23 |
| Aspirin for the Management of Endometriosis-associated Pelvic Pain Aspirin, Drospirenone ethinyl estradiol - Pelvic Pain | Phase 4 | Unknown | Women's Hospital School Of Medicine Zhejiang University | 220 | 2021-12-23 | 2022-01-24 |
| The Effect of Polycystic Ovary Syndrome Treatment on Metabolomics Yasmin, Diane-35 - Polycystic Ovary Syndrome | Not applicable | Unknown | Inonu University | 42 | 2021-03-01 | 2022-05-19 |
| Binge Eating & Birth Control Drospirenone-Ethinyl Estradiol Oral Tablet - Bulimia Nervosa, Binge Eating | Phase 2 | Terminated | University of North Carolina, Chapel Hill | 8 | 2020-09-24 | 2022-07-26 |
| Continuous Versus Cyclical OCP Use in PCOS Yasmin - Polycystic Ovary Syndrome | Phase 4 | Completed | University of California, San Francisco | 51 | 2019-04-01 | 2025-11-14 |
| Drug-drug Interaction Between Rifampicin and Progestins/Ethinylestradiol and Midazolam levonorgestrel/ Microlut, Norethindrone/ Noriday, Desogestrel/ Cerazette - Biological Availability | Phase 1 | Completed | Bayer | 68 | 2017-11-29 | 2020-04-15 |
| A Study in Healthy Female Participants to Investigate the Effect of JNJ-56136379 at Steady-state on the Single-dose Pharmacokinetics of Ethinylestradiol and Drospirenone (Oral Contraceptive) and on the Single-dose Pharmacokinetics of Midazolam (Probe Substrate for Cytochrome P450 3A4) Drospirenone/Ethinylestradiol, Midazolam, JNJ-56136379 - Healthy | Phase 1 | Completed | Janssen Sciences Ireland UC | 18 | 2017-03-27 | 2017-09-06 |
| E4/DRSP Ovarian Function Inhibition Study 15 mg E4/3 mg DRSP, 20 mcg EE/3 mg DRSP - Prevention of Pregnancy | Phase 2 | Completed | Estetra | 82 | 2017-02-07 | 2023-05-03 |
| Efficacy of Dienogest Versus Oral Contraceptive Pills on Pain Associated With Endometriosis Dienogest 2 MG Oral Tablet, Yasmin - Endometriosis | Phase 2 / Phase 3 | Unknown | American University of Beirut Medical Center | 100 | 2017-02-07 | 2021-04-15 |
| To Evaluate the Effects of Odalasvir and AL-335 With Simeprevir on the Single-Dose Pharmacokinetics of Ethinylestradiol and Drospirenone in Healthy Female Participants Drospirenone/ethinylestradiol, AL-335, Odalasvir (ODV) - Healthy | Phase 1 | Completed | Janssen Research & Development, LLC | 24 | 2016-08-01 | 2017-01-23 |
| YAZ Post Authorization Safety Study (PASS)/Post Authorization Efficacy Study (PAES) in China EE20/DRSP (YAZ, BAY86-5300) - Contraception | Phase 4 | Completed | Bayer | 1921 | 2016-05-27 | 2019-06-28 |
| Oral Contraceptives as Infertility Treatments for Premature Ovarian Failure Drospirenone and ethinyl estradiol combination (Yasmin) - Primary Ovarian Insufficiency, Menopause, Premature | Not applicable | Unknown | Navy General Hospital, Beijing | 20 | 2016-05-01 | 2016-05-02 |
| Levonorgestrel-releasing Intrauterine System Versus a Low-dose Combined Oral Contraceptive for Management of Adenomyosis Uteri Yasmin, Metraplant-E - Adenomyosis | Early Phase 1 | Unknown | Ain Shams Maternity Hospital | 32 | 2016-03-01 | 2017-01-31 |
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Polycystic Ovary Syndrome (12) · Acne Vulgaris (6) · Premenstrual Syndrome (5) · Premenstrual Dysphoric Disorder (4) · Endometriosis (3) · Hyperandrogenism (3) · Infertility (3) · Pelvic Pain (3) · Depression (2) · Dysmenorrhea (2) · Insulin Resistance (2) · Menstruation Disturbances (2) · Patient Compliance (2) · Acquired Immunodeficiency Syndrome (1) · Adenomyosis (1)
Bayer (25) · Massachusetts General Hospital (3) · Ahmed Saad (2) · Boehringer Ingelheim (2) · Cairo University (2) · Catholic University of the Sacred Heart (2) · Organon and Co (2) · Teva Pharmaceuticals USA (2) · University of North Carolina, Chapel Hill (2) · AGUNCO Obstetrics and Gynecology Centre (1) · Adana Numune Training and Research Hospital (1) · Ain Shams Maternity Hospital (1) · American University of Beirut Medical Center (1) · Beni-Suef University (1) · Brigham and Women's Hospital (1)
United States (19) · Germany (9) · Egypt (8) · China (6) · Italy (5) · Netherlands (4) · Canada (3) · Russia (3) · South Korea (3) · Thailand (3) · Belgium (2) · Brazil (2) · Lebanon (2) · Turkey (Türkiye) (2) · United Kingdom (2)
Anthony R Godfrey, Pharm.D. (2) · Abdelgany M Hassan, Lecturer (1) · Ahmed Maged, MD (1) · Ahmed Taha, Professor (1) · Alexandra B Kimball, MD, MPH (1) · Alexandra B. Kimball, MD, MPH (1) · Andrea Dunaif, MD (1) · Antoine Abu Musa, MD (1) · Benicio N Frey, MD, MSc,PhD (1) · Carmen Georgescu (1) · Christine Klipping (1)
PMID 21324454, PMID 21721590, PMID 18827119, PMID 19935020, PMID 21277674, PMID 21288628, PMID 21325466, PMID 21903192, PMID 22067789, PMID 22067790, PMID 22281416, PMID 22454003, PMID 22454004, PMID 22454006, PMID 22525910, PMID 22713099, PMID 22909145, PMID 23493606, PMID 23534865, PMID 23610531, PMID 24105751, PMID 24341612, PMID 25712537, PMID 26613823, PMID 26808666, PMID 27339759, PMID 28715852, PMID 28805601, PMID 31756117, PMID 31950432, PMID 34826668, PMID 35774693, PMID 37365881, PMID 37523477, PMID 39783453
2005 (3), 2017 (2), 2009 (1), 2014 (1), 2016 (1), K24HD001357 (1), R01DK073411 (1), R01MH081837 (1)