132 completed, 35 unknown, 12 not yet recruiting, 12 recruiting. 131 Not applicable, 19 Phase 3, 13 Phase 2, 11 Phase 4, 6 Phase 1.
Follow Premenstrual Syndrome: new trials by email Literature Review of Premenstrual Syndrome trials Research Report on Premenstrual Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The SPARK-PMDD Study Premenstrual Dysphoric Disorder, PMDD | Not yet recruiting | King's College London | 120 | 2027-01-01 | 2026-08-18 | |
| MLS101 Study in PMDD MLS101 psilocybin, Placebo capsules - Premenstrual Dysphoric Disorder ( PMDD), PMDD | Phase 1 | Not yet recruiting | MycoMedica Life Sciences PBC | 32 | 2026-12-01 | 2026-09-14 |
| The Effect of Mandala Coloring, Sleep Quality, Anxiety With Premenstrual Syndrome Mandala coloring group - Premenstrual Syndrome | Not applicable | Not yet recruiting | Kırklareli University | 80 | 2026-11-01 | 2026-08-25 |
| Transcutaneous Auricular Neurostimulation (tAN) for Premenstrual Dysphoric Disorder (PMDD) and Perimenopause transcutaneous auricular neurostimulation (tAN) - Perimenopause, PMDD | Not applicable | Enrolling by invitation | Texas Christian University | 20 | 2026-10-22 | 2026-10-23 |
| The Effects of Manual Lymphatic Drainage and Self-Manual Lymphatic Drainage Manual Lymphatic Drainage (MLD), Self-Manual Lymphatic Drainage (Self-MLD), Sham Manual Lymphatic Drainage (Sham MLD) - Premenstrual Syndrome | Not applicable | Not yet recruiting | Izmir Democracy University | 60 | 2026-10-05 | 2026-09-11 |
| A Clinical Trial to Evaluate the Effects of the Kaia Relief - Cycle System on Premenstrual Symptom Severity, Menstrual Discomfort, and Overall Well-Being in Premenopausal Women. Kaia Relief - Cycle System (Day and Night) - Premenstrual Syndrome, Menstrual Discomfort | Not applicable | Recruiting | Vivance Group | 45 | 2026-10-01 | 2026-10-15 |
| THE EFFECT OF A REFLEXOLOGY PROGRAM ON PREMENSTRUAL SYNDROME SYMPTOMS, QUALİTY OF LİFE AND GENERAL COMFORT Foot Reflexology Massage - Premenstrual Syndrome-PMS | Not applicable | Not yet recruiting | Dokuz Eylul University | 120 | 2026-10-01 | 2026-09-03 |
| Dose-Response Effects of a 6-Week Progressive Resistance Training Program on Premenstrual Syndrome in Adolescent Girls Progressive Resistance Training, Low-Intensity Resistance Training - Premenstrual Syndrome | Not applicable | Active not recruiting | Riphah International University | 32 | 2026-08-10 | 2026-09-22 |
| Aerobic Exercises Versus Sub Occipital Myofascial Release on Memory Function in Females With Premenstrual Syndrome. Aerobic exercise, Sub occipital myofascial release - Premenstrual Syndrome | Not applicable | Not yet recruiting | Cairo University | 40 | 2026-07-03 | 2026-07-06 |
| Self-Compassion and Quality of Life in Nursing Students With Premenstrual Syndrome Premenstrual Syndrome, Quality of Life | Completed | Acibadem University | 164 | 2026-06-26 | 2026-07-21 | |
| CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life Lutea Transcranial Direct Current Stimulation (tDCS) Device, Samphire Guided Care Program - Premenstrual Syndrome, Premenstrual Dysphoric Disorder | Recruiting | Samphire Group, Inc. | 50 | 2026-06-01 | 2026-07-01 | |
| Dual-Task Postural Stability in Women With Premstrual Syndrome: A Within-Subject Comparative Study PMS Group - Premenstrual Syndrome | Completed | Deraya University | 40 | 2026-05-15 | 2026-09-03 | |
| THE EFFECT OF GUİDED IMAGERY ON PREMENSTRUAL SYNDROME guided imagery - Guided Imagery, Premenstrual Syndrome | Not applicable | Completed | Baskent University | 61 | 2026-05-15 | 2026-10-22 |
| To Establish Whether Individuals With Premenstrual Dysphoric Disorder (PMDD) Demonstrate a Different Luteal-phase Sex Hormone Profile and Ratio Compared With Asymptomatic Controls. Premenstrual Dysphoric Disorder ( PMDD) | Recruiting | Lancaster University | 50 | 2026-05-05 | 2026-07-07 | |
| Combined Effect of Benson Relaxation Technique and Jacobson Progressive Muscle Relaxation Exercises on Premenstrual Syndrome Jacobson progressive muscle relaxation technique, Benson relaxation technique, combine Jacobson progressive muscle relaxation and Benson relaxation technique - Premenstrual Syndrome-PMS | Not applicable | Active not recruiting | University of Health Sciences Lahore | 56 | 2026-04-07 | 2026-04-13 |
| Efficacy and Safety of Shatavari Root Extract for Premenstrual Syndrome in Women Shatavari Root Extract, Placebo Capsule - Premenstrual Syndrome, Women Health | Not applicable | Not yet recruiting | SF Research Institute, Inc. | 60 | 2026-03-20 | 2026-03-03 |
| The Effect of Seed Cycling-Based Nutritional Intervention on Premenstrual Symptoms Seed consumption - Seed Cycling, Nutrition Habits | Active not recruiting | TC Erciyes University | 48 | 2026-03-20 | 2026-05-08 | |
| Occupational Physicians Facing Premenstrual Dysphoric Disorder: Knowledge, Perceptions and Practices in Occupational Health Premenstrual Dysphoric Disorder (PMDD) | Recruiting | University Hospital, Strasbourg, France | 15 | 2026-03-09 | 2026-10-07 | |
| Laughter Yoga and Sleep Hygiene Training for College Students With Premenstrual Syndrome Supportive Care - Laughter Yoga, Premenstrual Syndrome-PMS | Not applicable | Completed | Gazi University | 45 | 2026-03-01 | 2026-05-20 |
| Self-Acupressure for Primary Dysmenorrhea and Premenstrual Symptoms Self-Acupressure, Sham Self-Acupressure - Primary Dysmenorrhea, Premenstrual Syndrome | Not applicable | Recruiting | Nigde Omer Halisdemir University | 120 | 2026-02-15 | 2026-08-24 |
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Premenstrual Dysphoric Disorder (42) · Depression (16) · Dysmenorrhea (11) · Motor Activity (9) · Anxiety Disorders (8) · Menstruation Disturbances (7) · Pain (7) · Sleep Initiation and Maintenance Disorders (4) · Emotional Regulation (3) · Mood Disorders (3) · Acne Vulgaris (2) · Borderline Personality Disorder (2) · Depressive Disorder, Major (2) · Edema (2)
Pathologic Processes (202) · Pathological Conditions, Signs and Symptoms (202) · Menstruation Disturbances (195) · Mental Disorders (59) · Depressive Disorder (42) · Mood Disorders (42) · Behavior (34) · Signs and Symptoms (25) · Neurologic Manifestations (22) · Behavioral Symptoms (17) · Pain (14) · Pelvic Pain (10) · Nervous System Diseases (8) · Female Urogenital Diseases (6)
Exercise (11) · drospirenone and ethinyl estradiol combination (7) · Control Groups (5) · Fluoxetine (5) · Sertraline (5) · Yoga (5) · Exercise Movement Techniques (4) · Laughter Therapy (4) · Acupuncture Therapy (3) · Anti-Inflammatory Agents, Non-Steroidal (3) · Dietary Supplements (3) · Ethinyl Estradiol-Norgestrel Combination (3) · Progesterone (3) · drospirenone (3) · Contraceptives, Oral, Combined (2)
Cairo University (17) · National Institute of Mental Health (NIMH) (5) · Riphah International University (5) · Kırklareli University (4) · Saglik Bilimleri Universitesi (4) · University of North Carolina, Chapel Hill (4) · Eastern Mediterranean University (3) · Johns Hopkins University (3) · Kutahya Health Sciences University (3) · Sakarya University (3) · Wyeth is now a wholly owned subsidiary of Pfizer (3) · Adiyaman University Research Hospital (2) · Al-Azhar University (2) · Aydin Adnan Menderes University (2) · Bayer (2)
Turkey (Türkiye) (62) · United States (44) · Egypt (19) · Pakistan (7) · Brazil (6) · Germany (6) · Canada (5) · Sweden (5) · Israel (4) · Taiwan (4) · United Kingdom (4) · China (3) · Hungary (3) · Switzerland (3) · Cyprus (2)
Peter J Schmidt, M.D. (3) · Ellen W Freeman, PhD (2) · Kimberly A Yonkers, MD (2) · Liisa Hantsoo, PhD (2) · Margaret Altemus, MD (2) · Pedro E Martinez, M.D. (2) · Abdelgany M Hassan, Lecturer (1) · Abeer El-Deeb, professor (1)
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2023 (2), K23MH107831 (1), R01MH072955 (1), R01MH081837 (1), R01MH101547 (1), R01MH134904 (1), R01MH135896 (1), R21MH062379 (1), R21MH119642 (1), R34MH072878 (1)