89 completed, 71 unknown, 37 recruiting, 23 not yet recruiting. 83 Not applicable, 25 Phase 2, 21 Phase 4, 20 Phase 3, 6 Phase 1.
Follow Portal Hypertension: new trials by email Literature Review of Portal Hypertension trials Research Report on Portal Hypertension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fiber-Optic Navigation During TIPS Creation: A Prospective Pilot Study Fiber-Optic Navigation System - Liver Cirrhosis, Refractory Ascites | Not applicable | Not yet recruiting | Medical University Innsbruck | 30 | 2027-01-01 | 2026-03-13 |
| Within-Session Repeatability of EUS-Guided Portal Pressure Gradient Measurement Repeated EUS-Guided Portal Pressure Gradient Measurement - Portal Hypertension, Chronic Liver Disease | Not yet recruiting | University Hospital Muenster | 150 | 2027-01-01 | 2026-10-16 | |
| Different Treatment Frequencies for Hepatic Fibrosis Due to Schistosomiasis Praziquantel 40 mg/kg per dose given once annually, Praziquantel 40 mg/kg given three times per year - Schistosomiasis, Schistosoma Mansoni | Phase 2 / Phase 3 | Not yet recruiting | Rhode Island Hospital | 600 | 2026-11-01 | 2026-08-12 |
| Endohepatology-Based Reclassification of Treatment Indication in High-Risk MASLD Non-invasive MASLD and portal hypertension assessment, Single-session endohepatology assessment - Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis | Recruiting | University Hospital Muenster | 500 | 2026-10-05 | 2026-10-20 | |
| Baveno VIII Criteria for Portal Hypertension in Egyptian Patients Compensated Liver Disease, Esophageal Varices | Not yet recruiting | Assiut University | 125 | 2026-09-26 | 2026-09-25 | |
| Coil-Assisted Small-Diameter Covered-Stent Shunt Reduction for Refractory Hepatic Encephalopathy After TIPS Coil-assisted Small-diameter Stent Shunt reduction - Hepatic Encephalopathy, Transjugular Intrahepatic Portosystemic Shunt (TIPS) | Not applicable | Recruiting | Air Force Military Medical University, China | 30 | 2026-09-01 | 2026-09-02 |
| Body-weight Reduction Effect on Portal Hypertension in Compensated Cirrhosis Mazdutide injection - Cirrhosis, Portal Hypertension | Not applicable | Not yet recruiting | The Second Affiliated Hospital of Chongqing Medical University | 50 | 2026-09-01 | 2026-09-01 |
| 4D-Flow MRI Assessment of Portal Hypertension and TIPS Outcomes in Cirrhosis 4D-Flow Liver and heart MRI with Gadolinium injection, Samples Without DNA - Cirrhosis, Portal Hypertension | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2026-08-25 | 2026-10-13 |
| Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Gastric Varices EUS-Guided Coil Embolization With Cyanoacrylate Glue and Lipiodol, EUS-Guided Coil Embolization With Absorbable Gelatin Sponge - Gastric Varices Bleeding, Gastric Varices | Not applicable | Not yet recruiting | Unity Health Toronto | 64 | 2026-08-01 | 2026-07-13 |
| Underdilated VCX-TIPS Versus EVL Plus NSBB for Secondary Prophylaxis of Variceal Bleeding in Cirrhosis Underdilated VCX-TIPS, Endoscopic Variceal Ligation, Nonselective Beta-Blockers - Liver Cirrhosis, Portal Hypertension | Not applicable | Not yet recruiting | West China Hospital | 240 | 2026-08-01 | 2026-05-14 |
| Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up) Cirrhosis, Liver, Splenectomy; Status | Not yet recruiting | Northern Jiangsu People's Hospital | 30 | 2026-05-01 | 2026-05-18 | |
| Effect of LSD on Lipid Profiles in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up) Cirrhosis, Liver, Splenectomy; Status | Not yet recruiting | Northern Jiangsu People's Hospital | 30 | 2026-05-01 | 2026-05-14 | |
| Ultrasound Prediction of Esophageal Variceal Bleeding Risk Variceal Bleeding, Ultrasonography | Not yet recruiting | Assiut University | 165 | 2026-04-01 | 2026-05-06 | |
| Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis Apixaban, Carvedilol, Placebo - Cirrhosis, Esophageal and Gastric Varices | Phase 4 | Recruiting | Asian Institute Of Medical Sciences | 220 | 2026-04-01 | 2026-04-09 |
| Non-invasive Predictors of Esophageal Varices and Their Correlation to Upper Endoscopic Findings Esophageal Varices, Portal Hypertension | Not yet recruiting | Assiut University | 51 | 2026-03-20 | 2026-03-23 | |
| Austrian PBC Registry Primary Biliary Cholangitis, Liver Cirrhosis | Recruiting | Medical University of Vienna | 500 | 2026-03-18 | 2026-05-20 | |
| Optimizing Endoscopic and Interventional Treatment for Portal Hypertensive Bleeding Portal Hypertension, Gastroesophageal Varices Hemorrhage | Not yet recruiting | Shanghai Zhongshan Hospital | 1066 | 2026-03-17 | 2026-03-31 | |
| Exploration of Systemic and Portal Hemostasis in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt Placement Liver Cirrhosis, Portal Hypertension | Recruiting | Assistance Publique - Hôpitaux de Paris | 45 | 2026-03-09 | 2026-04-21 | |
| Inferior Vena Cava Pressure as Alternative to Hepatic Venous Pressure for EUS-guided Portal Pressure Gradient Measurement HVP-PPG and IVCP-PPG - Cirrhosis, Liver Disease Chronic | Completed | University Hospital Muenster | 40 | 2026-02-01 | 2026-07-14 | |
| Liver Cirrhosis Complicated by Clinically Significant Portal Hypertension SonoVue - Portal Hypertension, Spleen Disease | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 107 | 2026-02-01 | 2026-01-26 |
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Hypertension, Portal (240) · Liver Cirrhosis (89) · Fibrosis (71) · Esophageal and Gastric Varices (33) · Liver Diseases (14) · Ascites (12) · Hepatic Encephalopathy (10) · Carcinoma, Hepatocellular (8) · Gastrointestinal Hemorrhage (6) · Hepatitis B (6) · End Stage Liver Disease (5) · Hemorrhage (4) · Hypersplenism (4) · Non-alcoholic Fatty Liver Disease (4) · Acute-On-Chronic Liver Failure (3)
Digestive System Diseases (240) · Liver Diseases (226) · Pathological Conditions, Signs and Symptoms (155) · Pathologic Processes (152) · Fibrosis (73) · Gastrointestinal Diseases (39) · Esophageal Diseases (34) · Hepatic Insufficiency (18) · Liver Failure (17) · Cardiovascular Diseases (14) · Nervous System Diseases (14) · Central Nervous System Diseases (11) · Nutritional and Metabolic Diseases (11) · Brain Diseases (10) · Brain Diseases, Metabolic (10)
Carvedilol (16) · Portasystemic Shunt, Transjugular Intrahepatic (12) · Propranolol (11) · Endoscopy, Digestive System (4) · Rifaximin (4) · Somatostatin (4) · Terlipressin (4) · 3-(2-(2-tert-butylphenylaminooxalyl)aminopropionylamino)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid (3) · Endoscopy (3) · Lactulose (3) · Simvastatin (3) · Ultrasonography (3) · Elasticity Imaging Techniques (2) · Ethiodized Oil (2) · Magnetic Resonance Imaging (2)
West China Hospital (10) · Hepatopancreatobiliary Surgery Institute of Gansu Province (9) · Shanghai Zhongshan Hospital (9) · Nanfang Hospital, Southern Medical University (6) · Hvidovre University Hospital (5) · Medical University of Vienna (5) · Northern Jiangsu People's Hospital (5) · University Hospital, Bonn (5) · Aga Khan University (4) · Assiut University (4) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (4) · Air Force Military Medical University, China (3) · Assistance Publique - Hôpitaux de Paris (3) · Beijing Friendship Hospital (3) · Changqing Yang (3)
China (67) · United States (35) · Spain (19) · Germany (15) · France (12) · Austria (8) · Italy (8) · India (7) · Brazil (6) · Canada (6) · Denmark (5) · Egypt (5) · Pakistan (5) · Australia (4) · United Kingdom (4)
Xiaolong Qi, M.D. (5) · Guo-Qing Jiang, MD (4) · Arnulf Ferlitsch, MD (3) · Michael Praktiknjo, MD (3) · Shiyao Chen, Ph.D. (3) · Xiaolong Qi, MD (3) · Elliott Tapper, MD (2) · Flemming Bendtsen, Professor (2) · Flemming Forsberg, PhD (2) · Giuseppe Cullaro, MD, MAS (2) · Guadalupe Garcia-Tsao, MD (2) · Guohong Han, PhD & MD (2) · Huadong Yan, M.D. (2) · Jaime Bosch, MD (2)
PMID 35120736, PMID 41178521, PMID 22643348, PMID 24607624, PMID 26047908, PMID 27786365, PMID 28506905, PMID 33039403, PMID 33089892, PMID 41204773, PMID 10385721, PMID 10433004, PMID 10922085, PMID 10922086, PMID 10934332, PMID 10935792, PMID 11023560, PMID 11097479, PMID 1109749, PMID 11343232, PMID 11926560, PMID 12648985, PMID 1446890, PMID 14605701, PMID 14698338, PMID 1506645, PMID 15685546, PMID 15690481, PMID 16020491, PMID 16306522, PMID 16628644, PMID 16680632, PMID 16797100, PMID 16799972, PMID 17051449, PMID 17133503, PMID 17258346, PMID 17464971, PMID 17661241, PMID 17681169, PMID 18030211, PMID 18334275, PMID 18397389, PMID 18691352, PMID 19013661, PMID 19159076, PMID 19303163, PMID 20200386, PMID 20573925, PMID 20871126
2018 (2), R01DK098526 (2), 2014 (1), 2016 (1), R01AI184979 (1), R01DK046580 (1), R01DK113272 (1), U01DK062436 (1), U01DK062445 (1), U01DK062452 (1), U01DK062453 (1), U01DK062456 (1), U01DK062466 (1), U01DK062470 (1), U01DK062481 (1)