5 completed, 4 not yet recruiting, 4 recruiting, 4 unknown. 8 Not applicable, 2 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 3, Unknown 3, Recruiting 2 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
Follow Hypersplenism: new trials by email Literature Review of Hypersplenism trials Research Report on Hypersplenism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Laparoscopic Hepatectomy Combined With Splenectomy on Hepatic Functional Reserve and Immune Function Liver Cirrhosis, HCC - Hepatocellular Carcinoma | Recruiting | Northern Jiangsu People's Hospital | 30 | 2026-08-02 | 2026-09-10 | |
| Effect of Laparoscopic Splenectomy on Lipid Profiles in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up) Cirrhosis, Splenectomy; Status | Not yet recruiting | Northern Jiangsu People's Hospital | 30 | 2026-05-01 | 2026-05-14 | |
| Effect of LSD on Lipid Profiles in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up) Cirrhosis, Liver, Splenectomy; Status | Not yet recruiting | Northern Jiangsu People's Hospital | 30 | 2026-05-01 | 2026-05-14 | |
| Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up) Cirrhosis, Splenectomy; Status | Not yet recruiting | Northern Jiangsu People's Hospital | 30 | 2026-05-01 | 2026-05-18 | |
| Efficacy of Apixaban in Treating Portal Vein Thrombosis Occurring More Than One Year After LSD Apixaban 2.5 MG - Cirrhosis, Splenectomy | Not applicable | Recruiting | Northern Jiangsu People's Hospital | 20 | 2026-04-01 | 2026-03-31 |
| Vagus Nerve-guided Laparoscopic Splenectomy and Azygoportal Disconnection Vagus nerve-guided laparoscopic splenectomy and azygoportal disconnection - Cirrhosis, Hypersplenism | Not applicable | Recruiting | Northern Jiangsu People's Hospital | 15 | 2026-03-25 | 2026-04-01 |
| Hematological Disorders in EHPVO Patients No intervention (Observational Study) - Extrahepatic Portal Vein Obstruction (EHPVO), Thrombophilia | Not yet recruiting | Rahab Nady | 115 | 2025-08-01 | 2025-08-06 | |
| Study of the ITK Inhibitor Soquelitinib to Reduce Lymphoproliferation and Improve Cytopenias in Autoimmune Lymphoproliferative Syndrome (ALPS)-FAS Patients Soquelitinib - Autoimmune Lymphoproliferative Syndrome | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 15 | 2025-03-10 | 2026-09-08 |
| Effect of LSD on Lipid Profiles Within 1 Year Postoperatively in Cirrhosis Patients With Portal Hypertension Bleeding Lipid Profiles, Cirrhosis, Liver | Completed | Northern Jiangsu People's Hospital | 150 | 2022-05-01 | 2026-09-10 | |
| EUS-guided PSE in Combination With EUS-guided Treatment of Varices for Patients With Portal Hypertension coils, cyanoacrylate glue - Gastroesophageal Varices, Hypersplenism | Not applicable | Unknown | Tongji Hospital | 72 | 2021-01-05 | 2021-01-08 |
| A Randomized Controlled Study on the Treatment of Cirrhosis Combined With Hypersplenism Endoscopic therapy+ beta blockers, Endoscopic therapy+ PSE+beta blockers, Endoscopic therapy - Liver Cirrhosis, Esophageal and Gastric Varices | Not applicable | Unknown | Qilu Hospital of Shandong University | 368 | 2020-09-25 | 2022-03-02 |
| Transfemoral Versus Transradial Partial Splenic Artery Embolization in Patients With Hypersplenism partial splenic artery embolization - Hypersplenism | Not applicable | Completed | Zagazig University | 112 | 2019-06-01 | 2022-07-06 |
| Hypersplenism in Patients With Liver Cirrhosis and Portal Hypertension Hypersplenism | Unknown | Assiut University | 400 | 2017-09-01 | 2017-09-01 | |
| The Treatment of Hepatocirrhosis and Portal Hypertension Endoscopic therapy+ beta blockers, Endoscopic therapy+ PSE+beta blockers, beta blockers - Hepatic Cirrhosis, Portal Hypertension | Not applicable | Completed | Yanjing Gao | 108 | 2016-02-01 | 2025-02-14 |
| Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Microwave Thermal Coagulation, Partial Splenic Embolization - Hypersplenism | Not applicable | Unknown | Tanta University | 40 | 2014-08-01 | 2014-10-10 |
| Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS) Valproic Acid, CT Scan, Blood Sample - ALPS, Hypersplenism | Phase 1 / Phase 2 | Completed | Koneti Rao | 6 | 2008-01-01 | 2013-03-21 |
| Pre-emptive Transjugular Intrahepatic Portosystemic Shunt (TIPS) in Cystic Fibrosis Related Liver Disease TIPS - Cystic Fibrosis Liver Disease, Portal Hypertension Due to Cystic Fibrosis (Disorder) | Not applicable | Completed | University Hospital, Ghent | 5 | 2007-06-01 | 2021-09-08 |
Hypertension, Portal (9) · Fibrosis (6) · Liver Cirrhosis (5) · Autoimmune Lymphoproliferative Syndrome (2) · Thrombocytopenia (2) · Anemia (1) · Antiphospholipid Syndrome (1) · Autoimmune Lymphoproliferative Syndrome, Type IA (1) · Carcinoma, Hepatocellular (1) · Esophageal and Gastric Varices (1) · Gastrointestinal Hemorrhage (1) · Hematologic Diseases (1) · Hemoglobinuria, Paroxysmal (1) · Leukopenia (1)
Hemic and Lymphatic Diseases (17) · Lymphatic Diseases (17) · Splenic Diseases (17) · Digestive System Diseases (11) · Liver Diseases (11) · Pathological Conditions, Signs and Symptoms (11) · Pathologic Processes (10) · Autoimmune Diseases (3) · Fibrosis (3) · Immune System Diseases (3) · Blood Platelet Disorders (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Cytopenia (2) · Gastrointestinal Diseases (2) · Genetic Diseases, Inborn (2)
Adrenergic beta-Antagonists (1) · Blood Specimen Collection (1) · MK 6 cyanoacrylate (1) · Observation (1) · Portasystemic Shunt, Transjugular Intrahepatic (1) · Valproic Acid (1) · apixaban (1)
Northern Jiangsu People's Hospital (7) · Assiut University (1) · Koneti Rao (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Qilu Hospital of Shandong University (1) · Rahab Nady (1) · Tanta University (1) · Tongji Hospital (1) · University Hospital, Ghent (1) · Yanjing Gao (1) · Zagazig University (1)
China (10) · Egypt (2) · United States (2)
Guo-Qing Jiang, MD (5) · Asem A Elfert, MD (1) · Bin Cheng, Ph.D, M.D (1) · Dou-Sheng Bai (1) · Dou-Sheng Bai, MD (1) · Fat-heya E Assel, MD' (1) · Guo-Qing Jiang (1) · Islam S Ismail (1) · Koneti Rao, MD (1) · Luc Defreyne, M.D., Ph.D (1) · Mohamed M Elkassas (1) · Mohamed MA Zaitoun, MD (1) · Qian Chen, Ph.D, M.D (1)
PMID 107745, PMID 12239963, PMID 15246206, PMID 15625453, PMID 15674095, PMID 15862259, PMID 17377043, PMID 17943410, PMID 18412294, PMID 19070555, PMID 19380572, PMID 2071835, PMID 21343515, PMID 22021698, PMID 25741193, PMID 27703501, PMID 33638769, PMID 37486372, PMID 8340060, PMID 9124620