18 completed, 3 terminated, 1 recruiting, 1 withdrawn. 23 Phase 2, 4 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 23 | Completed 18, Terminated 3, Recruiting 1, Withdrawn 1 |
| Phase 3 | 4 | Completed 3, Withdrawn 1 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
Follow Otitis Media: new trials by email Literature Review of Otitis Media trials Research Report on Otitis Media
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of wSp Vaccine in Young Children wSp vaccine, Saline (0.9% NaCl) - Acute Otitis Media (AOM) | Phase 2 | Recruiting | Serum Life Science Europe GmbH | 320 | 2025-09-29 | 2026-09-23 |
| Effects of 100% Medical Grade Manuka Honey on Tympanic Membrane Reconstruction Healing. Manukamed - Manukapli 100% sterile honey wound dressing - Premium medical grade 16+ Leptospermum Scoparium New Zealand honey - Otitis Media, Suppurative, Tympanic Membrane Perforation | Phase 2 / Phase 3 | Completed | Fakultas Kedokteran Universitas Indonesia | 64 | 2021-06-13 | 2022-11-04 |
| A Study to Assess the Safety, Tolerability and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Media in Infants and Children Aged 6 to 24 Months OP0201, Placebo, Amoxicillin-clavulanate - Acute Otitis Media | Phase 2 | Completed | Novus Therapeutics, Inc | 103 | 2019-02-21 | 2020-08-18 |
| Xylitol for Otitis Media Intranasal xylitol spray, Intranasal saline spray - Otitis Media With Effusion | Phase 2 / Phase 3 | Withdrawn | Duke University | 2017-11-20 | 2017-12-22 | |
| Adult Study to Evaluate Placement of Tympanostomy Tubes In-office (ADEPT) Tymbion Iontophoresis and Tube Delivery System (TDS) - Barotrauma;Ear, OME - Otitis Media With Effusion | Phase 2 | Completed | Tusker Medical | 30 | 2017-06-27 | 2020-01-18 |
| A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea piperacillin 4% + tazobactam 0.5% + dexamethasone 0.1%, piperacillin 8% + tazobactam 1.0% + dexamethasone 0.1%, piperacillin 2% + tazobactam 0.25% - Otitis Media, Otorrhea | Phase 1 / Phase 2 | Terminated | Yuhan Corporation | 135 | 2016-06-01 | 2022-01-13 |
| Dose Ranging Study of OTO-201 in AOMT 6 mg ciprofloxacin, 12 mg ciprofloxacin, Sham - Acute Otitis Media, AOMT | Phase 2 | Completed | Otonomy, Inc. | 95 | 2016-02-01 | 2020-10-19 |
| Open-Label Study of OTO-201 for Treatment of AOMT OTO-201 - Acute Otitis Media, AOMT | Phase 2 | Completed | Otonomy, Inc. | 39 | 2015-03-01 | 2020-10-19 |
| Proof-of-Concept Study of a Single Application of an Investigational Otic Suspension in Treatment of Acute Otitis Media With Tympanostomy Tubes AL-60371/AL-817 otic suspension, Ciprofloxacin 0.3%/dexamethasone 0.1% otic suspension - Acute Otitis Media | Phase 2 | Terminated | Alcon Research | 84 | 2013-12-01 | 2017-12-06 |
| Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Media Antipyrine and Benzocaine otic solution, Antipyrine Otic Solution, Benzocaine Otic Solution - Acute Otitis Media | Phase 2 | Completed | Currax Pharmaceuticals | 112 | 2013-11-01 | 2024-08-07 |
| Study to Assess the Safety and Efficacy of Benzocaine for Pain Relief in Children Presenting With Acute Otitis Media Benzocaine, Placebo - Pain, Acute Otitis Media | Phase 2 | Completed | Otic Therapy, LLC | 65 | 2013-09-01 | 2015-05-25 |
| Study of FAECC Scale (Modified FLACC) to Evaluate Ear Pain in Children With Acute Otitis Media benzocaine, placebo - Pain, Otitis Media | Phase 2 | Completed | Arbor Pharmaceuticals, Inc. | 38 | 2012-05-01 | 2015-05-04 |
| Efficacy of Short-Course Antimicrobial Treatment for Children With Acute Otitis Media and Impact on Resistance Amoxicillin-Clavulanate, 10 days, Amoxicillin-Clavulanate, 5 days - Acute Otitis Media | Phase 2 | Terminated | Alejandro Hoberman | 520 | 2012-01-01 | 2017-10-06 |
| Effect of Simethicone on Eustachian Tube Dysfunction Simethicone, Placebo - Otitis Media | Phase 2 | Completed | University of Pittsburgh | 25 | 2011-03-01 | 2016-06-27 |
| Evaluation of the Tympanostomy Tube Delivery System tympanostomy tube - Otitis Media With Effusion, Acute Otitis Media | Phase 2 / Phase 3 | Completed | Integra LifeSciences Corporation | 53 | 2010-09-01 | 2024-08-06 |
| Pharmacokinetics Of Azithromycin Immediate Release And Extended Release Formulation In Kids With Acute Otitis Media 60 mg/kg azithromycin ER, 30 mg/kg azithromycin IR - Acute Otitis Media | Phase 2 | Completed | Pfizer | 38 | 2008-12-01 | 2010-02-18 |
| A Phase II Study of an Otic Formulation in Treating Peri-Operative Tube Otorrhea Moxidex otic solution, Moxifloxacin otic solution, Tympanostomy tubes - Acute Otitis Media | Phase 2 | Completed | Alcon Research | 303 | 2007-11-01 | 2012-12-03 |
| Adenoidectomy, Myringotomy and Tubes' Insertion vs Adenoidectomy and Myringotomy Alone in Children With Otitis Media With Effusion and Adenoid Hypertrophy adenoidectomy, myringotomy, tubes insertion, A-M - Otitis Media With Effusion | Phase 2 | Completed | Aghia Sophia Children's Hospital of Athens | 52 | 2007-09-01 | 2012-01-23 |
| A Trial to Evaluate Faropenem Medoxomil in the Treatment of Acute Otitis Media Faropenem Medoxomil - Otitis Media | Phase 2 | Completed | Replidyne | 328 | 2006-01-01 | 2008-02-08 |
| Neonatal Immunization With Pneumococcal Conjugate Vaccine in Papua New Guinea Pneumococcal 7 valent conjugate vaccine (Prevenar®) - Pneumonia, Meningitis | Phase 2 | Completed | Papua New Guinea Institute of Medical Research | 318 | 2005-05-01 | 2011-07-12 |
Showing 20 of 23. Sign in to see all of them.
Otitis Media with Effusion (4) · Otitis (3) · Pain (2) · Communicable Diseases (1) · Meningitis (1) · Otitis Media, Suppurative (1) · Pneumonia (1) · Tympanic Membrane Perforation (1)
Ear Diseases (23) · Otorhinolaryngologic Diseases (23) · Otitis (20) · Pathological Conditions, Signs and Symptoms (3) · Infections (2) · Neurologic Manifestations (2) · Signs and Symptoms (2) · Disease Attributes (1) · Lung Diseases (1) · Nervous System Diseases (1) · Neuroinflammatory Diseases (1) · Pathologic Processes (1) · Respiratory Tract Diseases (1) · Respiratory Tract Infections (1)
Amoxicillin-Potassium Clavulanate Combination (2) · Benzocaine (2) · Ciprofloxacin (2) · Middle Ear Ventilation (2) · Adenoidectomy (1) · Antipyrine (1) · Azithromycin (1) · Cefdinir (1) · Dexamethasone (1) · Heptavalent Pneumococcal Conjugate Vaccine (1) · Piperacillin (1) · Pneumococcal Vaccines (1) · Simethicone (1) · Sodium Chloride (1) · Tazobactam (1)
Alcon Research (2) · Otonomy, Inc. (2) · Abbott (1) · Aghia Sophia Children's Hospital of Athens (1) · Alejandro Hoberman (1) · Arbor Pharmaceuticals, Inc. (1) · Currax Pharmaceuticals (1) · Duke University (1) · Fakultas Kedokteran Universitas Indonesia (1) · Integra LifeSciences Corporation (1) · National Center for Complementary and Integrative Health (NCCIH) (1) · National Institute on Deafness and Other Communication Disorders (NIDCD) (1) · Novus Therapeutics, Inc (1) · Otic Therapy, LLC (1) · Papua New Guinea Institute of Medical Research (1)
United States (14) · Costa Rica (3) · Israel (2) · Chile (1) · Dominican Republic (1) · Greece (1) · Guatemala (1) · Indonesia (1) · Panama (1) · Papua New Guinea (1) · South Korea (1)
Carl LeBel, PhD (2) · Alejandro Hoberman, MD (1) · Amy Agua, MD (1) · Andrew Gould, MD (1) · Bryan Harvey, MD (1) · Charles Syms, MD (1) · David Yen, MD (1) · Deborah Lehmann, MBBS, Msc (1) · Gerald Shockey, MD (1) · Harim Priyono (1) · Ioannis M Vlastos, MD (1) · Jacob Zeiders, MD (1) · James Hendrick, MD (1)
PMID 18831749, PMID 19150378, PMID 19776196, PMID 21645573, PMID 23451070, PMID 24911895, PMID 25444821, PMID 28002709, PMID 28580433, PMID 28702291, PMID 29028802, PMID 34851411, PMID 37171965, PMID 42572144
P50AT000008 (1), U01AI172733 (1)