33 completed, 6 unknown, 4 not yet recruiting, 2 recruiting. 16 Phase 4, 14 Not applicable, 9 Phase 3, 7 Phase 2, 4 Phase 1.
Follow Simethicone: new trials by email Literature Review of Simethicone trials Research Report on Simethicone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Simethicone on Colon Preparation During Water Exchange Colonoscopy Simethicone with PEG, PEG - Quality of Bowel Preparation | Not applicable | Not yet recruiting | Dalin Tzu Chi General Hospital | 180 | 2026-08-01 | 2026-06-29 |
| Effect of Intraluminal Administration of Menthol Solution During Colonoscopy on Colonic Spasm and Adenoma Detection Rate Endoscopic irrigation was performed using a 0.1% menthol solution combined with simethicone., Endoscopic irrigation was performed using an aqueous suspension prepared with simethicone and normal saline. - Colonoscopy | Not applicable | Not yet recruiting | The First Affiliated Hospital of Zhengzhou University | 440 | 2026-04-01 | 2026-03-30 |
| Effect of Simethicone on Helicobacter Pylori Detection in Routine Endoscopy Simeticone, placebo (plain water) - H Pylori Infection | Not applicable | Not yet recruiting | Asian Institute of Gastroenterology, India | 100 | 2026-01-01 | 2026-01-02 |
| Premedication With N-acetylcysteine and Simethicone to Improve Mucosal Visualization in Elective Upper Endoscopy Premedication with n-acetylcysteine, Placebo (drinking water), Premedication with simethicone - Esophagogastroduodenoscopy, Simethicone | Phase 2 | Recruiting | Hospital General de Mexicali | 132 | 2025-09-12 | 2025-11-24 |
| Simethicone as Part of ERAS in Bariatric Surgery Patients Simethicone 80 MG, Placebo - Simethicone, Bariatric Surgery | Phase 4 | Recruiting | Madigan Army Medical Center | 260 | 2025-04-08 | 2025-06-15 |
| Impact of Timing of Premedication on Mucosal Visibility During Endoscopy-A Randomized Controlled Trial Simethicone plus NAC - Endoscopy, Digestive System | Not applicable | Completed | Asian Institute of Gastroenterology, India | 1200 | 2024-12-01 | 2025-05-06 |
| Exploratory Pilot Study to Evaluate the Pharmacokinetic Profile of Magaldrate Sodium alginate + sodium bicarbonate + magaldrate + simeticone - Healthy | Phase 4 | Completed | Tecnoquimicas | 10 | 2023-10-31 | 2024-04-16 |
| The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION) alverine-citrate + simethicone and lactase, alverin-citrate + simethicone with placebo - Irritable Bowel Syndrome, Lactose Intolerance | Not applicable | Not yet recruiting | University of Pecs | 200 | 2022-09-01 | 2021-10-29 |
| Pre-medication With N-acetylcysteine and Simethicone to Improve Mucosal Visibility During Gastroduodenoscopy Simethicone 150mg, N Acetyl cysteine 600mg, Simethicone 150mg plus N Acetyl cysteine 600 mg - Mucosal Erosion | Not applicable | Completed | Asian Institute of Gastroenterology, India | 800 | 2022-06-16 | 2023-07-24 |
| The Impact of Air Travel on Passenger Cognitive Functions Citicoline, Cytochrome C6, Sodium Chloride Oral Product - Air Travel | Phase 2 / Phase 3 | Unknown | Dinara Zhumanbayeva | 50 | 2021-06-01 | 2021-03-17 |
| Low-volume vs High-volume Polyethylene Glycol Based Bowel Preparation for Colonoscopy in People Receiving Hemodialysis 2-liters polyethylene glycol with citrate and simethicone, 4-liters polyethylene glycol with simethicone, Low-residue diet - Chronic Kidney Diseases, Colon Polyp | Phase 4 | Unknown | Alfredo Di Leo | 264 | 2021-02-01 | 2021-01-14 |
| Efficacy and Safety of Mebeverine + Simethicone in Patients With Functional Bowel Disorders Mebeverine+Simethicone, Mebeverine, Simethicone - Functional Bowel Disorder | Phase 3 | Completed | Abbott | 465 | 2020-11-27 | 2025-09-16 |
| Study to Examine the Effect of Antacid and Omeprazole on the Single-Dose Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects Tebipenem pivoxil hydrobromide (TBPM-PI-HBr), 20 mL aluminum hydroxide/magnesium hydroxide/simethicone (400 mg aluminum hydroxide/400 mg magnesium hydroxide/40 mg simethicone per 5 mL), Omeprazole - Healthy Volunteers | Phase 1 | Completed | Spero Therapeutics | 20 | 2020-07-01 | 2020-09-04 |
| Effects of Vivatlac Baby on Crying Behavior of Colicky Babies Simethicone Solution, Vivatlac Baby - Infantile Colic | Phase 2 | Completed | The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz | 87 | 2020-04-16 | 2023-11-22 |
| A Study of Combination Caplet With Loperamide Hydrochloride and Simethicone, and Imodium Express Tablets-lyophilizate Coadministered With Espumisan Capsule in Healthy Volunteers Combination Caplet with Loperamide HCl and Simethicone, Loperamide HCl, Simethicone - Healthy | Phase 1 | Completed | McNeil AB | 48 | 2019-12-05 | 2020-09-10 |
| Effect of Adding Simethicone to Split-dose Polyethylene Glycol for Bowel Preparation in a Screening Colonoscopy Setting PEG split-dose and simethicone - Colo-rectal Cancer, Colonic Neoplasms | Not applicable | Completed | Portuguese Oncology Institute, Coimbra | 412 | 2019-06-15 | 2022-10-05 |
| Combination of Alverine-simeticone and i3.1 Probiotic in IBS-D and IBS-M in Mexico I31 probiotic, I31 probiotic combined to Alverine/Simethicone, Placebo - Irritable Bowel Syndrome | Phase 4 | Completed | Hospital Juarez de Mexico | 55 | 2018-09-03 | 2020-01-23 |
| Effect of Simethicone on Reducing Bowel Interference During Tubal Resection Simethicone 80 MG - Sterility, Postpartum | Phase 3 | Completed | Chiang Mai University | 120 | 2018-03-08 | 2020-02-05 |
| Effect of Domperidone on Completion Rate of Vedio Capsule Endoscopy Domperidone, water - Capsule Endoscopy, Pediatric Disorder | Not applicable | Completed | Children's Hospital of Fudan University | 200 | 2017-11-01 | 2018-12-17 |
| Simethicone and Bowel Preparation in Colonoscopy Simethicone 180Mg Cap - Colonoscopy, Bowel Preparation | Phase 4 | Completed | University of Manitoba | 471 | 2017-07-05 | 2018-05-23 |
Showing 20 of 48. Sign in to see all of them.
Irritable Bowel Syndrome (5) · Abdominal Pain (3) · Colorectal Neoplasms (3) · Colic (2) · Colonic Neoplasms (2) · Flatulence (2) · Stomach Neoplasms (2) · Colonic Polyps (1) · Constipation (1) · Diarrhea (1) · Dyspepsia (1) · Gastrointestinal Hemorrhage (1) · Hemorrhage (1) · Ileus (1) · Infertility, Female (1)
Asian Institute of Gastroenterology, India (3) · Laboratoires Mayoly Spindler (2) · McNeil AB (2) · Portuguese Oncology Institute, Coimbra (2) · ASST Rhodense (1) · Abbott (1) · Albany Medical College (1) · Alfredo Di Leo (1) · Asan Medical Center (1) · Assiut University (1) · Boehringer Ingelheim (1) · CM Chungmu Hospital (1) · Changhai Hospital (1) · Changi General Hospital (1) · Chiang Mai University (1)
United States (11) · India (3) · Mexico (3) · South Korea (3) · Brazil (2) · Canada (2) · China (2) · Hungary (2) · Poland (2) · Portugal (2) · Russia (2) · Thailand (2) · Chile (1) · Egypt (1) · Italy (1)
Abhasnee Sobhonslidsuk, M.D. (1) · Adolfo Parra-Blanco, MD (1) · Adrian Miranda, MD (1) · Alfredo Di Leo, MD PhD (1) · Annamaria Staiano, Prof. (1) · Antonio H Mendoza-Ladd, MD (1) · Asra Batool, MD (1) · Cagla Eskicioglu, MD, MSc (1) · Carlos Fernando Francesconi, MD (1) · Charlenn Skead, BA (1) · David Kastenberg, MD (1) · David Melnick, M.D. (1) · Dr.Mohan Kumar Ramchandani, MD, DM (1) · Elisabeth Kruse, PhD (1) · Elizabeth Rajan, M.D. (1)
PMID 15044883, PMID 19554657, PMID 10343249, PMID 11156645, PMID 11857360, PMID 12170403, PMID 1305308, PMID 1479177, PMID 15738894, PMID 15818423, PMID 15888773, PMID 16266222, PMID 16564908, PMID 16937471, PMID 17230616, PMID 18005366, PMID 19198022, PMID 19418602, PMID 20148732, PMID 20871410, PMID 21481857, PMID 21826120, PMID 22142434, PMID 22239959, PMID 22356322, PMID 24147869, PMID 24325147, PMID 24496417, PMID 26541878, PMID 26880894, PMID 27144617, PMID 27487795, PMID 27548885, PMID 27603372, PMID 27852098, PMID 28665038, PMID 28985630, PMID 29132175, PMID 29971260, PMID 30658942, PMID 30926430, PMID 31044749, PMID 31451919, PMID 32016519, PMID 32355887, PMID 32419949, PMID 3292345, PMID 33538338, PMID 33708520, PMID 33765904