24 completed, 7 unknown, 4 terminated, 1 active not recruiting. 9 Not applicable, 9 Phase 4, 8 Phase 3, 4 Phase 2, 3 Phase 1.
Follow Piperacillin: new trials by email Literature Review of Piperacillin trials Research Report on Piperacillin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Appropriateness of Antibiotic Combination Therapy for Severe Community-acquired Pneumonia in South Korea Piperacillin/Tazobactam, Piperacillin/tazobactam + Levofloxacin - Severe Community-acquired Pneumonia (sCAP) | Not applicable | Not yet recruiting | CHOSEOK YOON | 100 | 2025-06-15 | 2025-05-18 |
| Comparison Between Carbapenems and Noncarbapenem Beta-lactam Antibiotics in Septic Burn Patients Meropenem I.V. 2g as a 3 hour infusion every 8 hours, Tazocin (pipercillin/tazobactam) - Sepsis | Phase 1 / Phase 2 | Active not recruiting | Ain Shams University | 400 | 2024-01-01 | 2025-10-03 |
| Population Pharmacokinetic of Piperacillin/Tazobactam in Maternal and Neonatal Populations Piperacillin Sodium and Tazobactam Sodium for Injection - Early-Onset Neonatal Sepsis | Recruiting | Shandong University | 50 | 2023-09-30 | 2023-10-10 | |
| Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Intensive Care Unit Piperacillin/tazobactam or temocillin, Meropenem - Sepsis, Septic Shock | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 600 | 2023-03-11 | 2023-04-18 |
| Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy Piperacillin and Tazobactam in gel form, Amoxicillin and Metronidazole - Periodontitis | Not applicable | Completed | University of Belgrade | 38 | 2023-01-17 | 2025-07-17 |
| BL Infusion Trial:Beta-lactam Continuous Versus Intermittent Infusion and Associated Bacterial Resistance and Therapy Outcomes in Critically Ill Patients With Severe Pneumonia Cefepime, Meropenem, or Piperacillin/Tazobactam - Pneumonia | Phase 4 | Terminated | University of Florida | 35 | 2021-12-17 | 2023-12-12 |
| Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia Piperacillin and Tazobactam for Injection, Cefepime Injection, Ceftazidime Injection - Febrile Neutropenia | Phase 4 | Completed | Murdoch Childrens Research Institute | 55 | 2021-11-15 | 2026-03-20 |
| Observed Pharmacokinetic of Piperacillin/Tazobactam Compared to Amikacin in ICU Plasma dosage of amikacin, piperacillin and tazobactam - Septic Shock, Sepsis | Not applicable | Unknown | Hospices Civils de Lyon | 60 | 2021-01-28 | 2022-09-30 |
| Monitoring of Piperacillin-Tazobactam and Meropenem Plasmatic Levels in Critical Patients Piperacillin/tazobactam or Meropenem - Sepsis, Septic Shock | Unknown | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 200 | 2020-02-15 | 2020-02-06 | |
| Pharmacokinetics of Piperacillin and Meropenem in ICU Patients Piperacillin/tazobactam, Meropenem - Antibiotic Pharmacokinetics | Unknown | Karolinska University Hospital | 50 | 2019-11-01 | 2021-11-24 | |
| PNEUmonia DOSing in Critically Ill Patients (PNEUDOS) Blood sampling, Epithelial lining fluid sampling, Urine sampling - Pneumonia | Completed | The University of Queensland | 179 | 2019-10-17 | 2026-01-28 | |
| Antibiotic Therapy for Early Onset Neonatal Sepsis Piperacillin and tazobactam, azlocillin, latamoxef, meropenem, vancomycin，cefotaxime - Early Onset Neonatal Sepsis | Unknown | Shandong University | 500 | 2019-05-05 | 2021-04-20 | |
| Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic UTI Due to -ESBL-producing Enterobacteriaceae Meropenem, Ertapenem 1000 MG, Piperacillin, Tazobactam 4-0.5G Solution for Injection - Urinary Tract Infections, Enterobacteriaceae Infections | Phase 4 | Suspended | Universidad del Norte | 198 | 2019-04-01 | 2024-12-06 |
| Safety and Efficacy of Vancomycin Plus Beta-lactams vancomycin plus piperacillin/tazobactam, vancomycin plus other beta-lactams - Critical Illness | Completed | First Affiliated Hospital Xi'an Jiaotong University | 700 | 2018-12-12 | 2020-06-23 | |
| Extended-infusion of Piperacillin-Tazobactam Versus Intermittent Infusion Piperacillin/Tazobactam Continuous infusion, Piperacillin/Tazobactam Intermittent infusion - Gram-Negative Infections | Phase 4 | Completed | Ain Shams University | 56 | 2018-07-27 | 2021-05-20 |
| Acute Appendicitis: Active Observation With and Without Antibiotics Antibiotic treatment (Piperacillin/Tazobactam, 4 gram x 3), followed by 8-10 days of out-hospital oral antibiotic treatment (Ciprofloxacin 500 mgx2,Flagyl 400 mgx3)., Active observation - Appendicitis | Phase 4 | Completed | Göteborg University | 126 | 2018-05-15 | 2022-08-16 |
| Optimal Care of Complicated Appendicitis Early Appendectomy, Interval Appendectomy, Antibiotics - Appendicitis, Perforated Appendicitis | Phase 4 | Completed | University of Michigan | 40 | 2017-06-29 | 2023-11-28 |
| Glycocalyx Damage and Beta-lactam Antibiotics in Surgical Critically Ill Meropenem - Critical Illness | Completed | University Hospital Hradec Kralove | 20 | 2017-05-02 | 2018-10-24 | |
| A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea piperacillin 4% + tazobactam 0.5% + dexamethasone 0.1%, piperacillin 8% + tazobactam 1.0% + dexamethasone 0.1%, piperacillin 2% + tazobactam 0.25% - Otitis Media, Otorrhea | Phase 1 / Phase 2 | Terminated | Yuhan Corporation | 135 | 2016-06-01 | 2022-01-13 |
| Imipenem/Relebactam/Cilastatin Versus Piperacillin/Tazobactam for Treatment of Participants With Bacterial Pneumonia (MK-7655A-014) Imipenem, Relebactam, Cilastatin - Bacterial Pneumonia | Phase 3 | Completed | Merck Sharp & Dohme LLC | 537 | 2015-11-24 | 2020-04-16 |
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Critical Illness (4) · Sepsis (4) · Shock, Septic (4) · Appendicitis (3) · Bacterial Infections (3) · Infections (3) · Osteomyelitis (3) · Diabetes Mellitus (2) · Diabetic Foot (2) · Neonatal Sepsis (2) · Neoplasms (2) · Pneumonia (2) · Urinary Tract Infections (2) · Abscess (1) · Blast Crisis (1)
Wyeth is now a wholly owned subsidiary of Pfizer (5) · Ain Shams University (2) · Merck Sharp & Dohme LLC (2) · Shandong University (2) · Assaf-Harofeh Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Bayer (1) · CHOSEOK YOON (1) · Chinese PLA General Hospital (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · Göteborg University (1) · Hospices Civils de Lyon (1) · Ito Hospital (1)
United States (10) · China (7) · France (6) · South Korea (4) · Belgium (3) · Czechia (3) · Greece (3) · Israel (3) · Spain (3) · Australia (2) · Bulgaria (2) · Canada (2) · Egypt (2) · Germany (2) · Hungary (2)
Andres F Estupinan Bohorquez, MD (1) · Arie Soroksky, MD (1) · Aya A Bayoumy, MD (1) · Changqing Li, doctor (1) · Charles Peloquin (1) · David Seligson, MD (1) · Diego F Viasus Perez, MD. PhD. (1) · Feng-Yee Chang (1) · Francois I. Luks, MD, PhD (1) · Gabrielle Haeusler (1) · Iva Z Milinkovic, DDS, PhD (1)
PMID 15276398, PMID 15840453, PMID 19588358, PMID 21896561, PMID 22530208, PMID 23180507, PMID 26888908, PMID 29486041, PMID 31786695, PMID 32785589, PMID 33188385, PMID 33743171, PMID 34704389, PMID 37383243, PMID 41586496, PMID 42743113, PMID 4902833, PMID 8948280
2015 (1)