21 completed, 12 unknown, 5 recruiting, 5 withdrawn. 24 Not applicable, 6 Phase 3, 5 Phase 2, 2 Early Phase 1, 2 Phase 4.
Follow Tympanic Membrane Perforation: new trials by email Literature Review of Tympanic Membrane Perforation trials Research Report on Tympanic Membrane Perforation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Outcomes of Cartilage Tympanoplasty in Children Cartilage Tympanoplasty - Tympanic Membrane Perforation, Conductive Hearing Loss | Not applicable | Not yet recruiting | Assiut University | 35 | 2026-11-01 | 2026-10-08 |
| Boomerang-Shaped Cartilage Graft in Endoscopic Tympanoplasty Endoscopic Type I Tympanoplasty with Boomerang-Shaped Chondroperichondrial Graft - Tympanic Membrane Perforation, Chronic Otitis Media | Not applicable | Not yet recruiting | Assiut University | 50 | 2026-10-01 | 2026-09-17 |
| Does Adding a Fascial Layer to the Cartilage in Tympanoplasty for Large Tympanic Membrane Perforation Affect the Overall Results? Conchal Cartilage and Perichondrium Tympanoplasty, Conchal Cartilage, Perichondrium, and Temporalis Fascia Tympanoplasty - Tympanic Membrane Perforation, Otitis Media | Not applicable | Not yet recruiting | Assiut University | 50 | 2026-10-01 | 2026-09-22 |
| Insulin Intratympanic Application Insulin (Humulin), foam - Tympanic Membrane Perforation | Early Phase 1 | Completed | Deraya University | 50 | 2026-03-20 | 2026-09-04 |
| Platelet-Rich Fibrin in Revision Cartilage Tympanoplasty PRF-supported conchal cartilage tympanoplasty under local anesthesia - Tympanic Membrane Perforation, Chronic Otitis Media | Not applicable | Recruiting | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 35 | 2026-02-15 | 2026-10-26 |
| Effectiveness of Silver Nitrate Cauterization vs Conservative Management in Tympanic Membrane Perforation Closure 50% Silver Nitrate Cauterization - Tympanic Membrane Perforation | Not applicable | Terminated | Muhammad Ali Javed | 56 | 2026-02-01 | 2026-11-02 |
| A Prospective Comparative Study of Dry vs Wet Temporalis Fascia Graft in Tympanoplasty Wet Temporalis Fascia Graft Tympanoplasty, Dry Temporalis Fascia Graft Tympanoplasty - Chronic Otitis Media, Tympanic Membrane Perforation | Not applicable | Completed | Shaikh Zayed Hospital, Lahore | 92 | 2025-09-10 | 2026-05-19 |
| Comparison of Postoperative Outcomes of Interlay vs Underlay Graft in Tympanoplasty Underlay Tympanoplasty, Interlay Tympanoplasty - Chronic Otitis Media, Tympanic Membrane Perforation | Not applicable | Completed | Shaikh Zayed Hospital, Lahore | 60 | 2025-01-09 | 2025-09-02 |
| Otological Study of Facial Cleft Patients Over 10 Years of Age (Excluding Isolated Cleft Lip) (EFEOF) Serous Otitis, Tympanic Membrane Perforation | Unknown | University Hospital, Brest | 500 | 2024-12-12 | 2024-12-18 | |
| Trans Canal Tympanoplasty With Local Anesthesia Using Fat Graft and "TachoSil" Tympanoplasty performed under local anesthesia using fat graft and "Tachosil". - Tympanic Membrane Perforation | Not applicable | Unknown | HaEmek Medical Center, Israel | 20 | 2024-09-01 | 2024-08-13 |
| Comparison of Topical Use of Platelet-rich Plasma Versus Hyaluronic Acid During Endoscopic Fat Graft Myringoplasty: a Randomized Clinical Study enoscopic Myringoplasty - Chronic Suppurative Otitis Media | Not applicable | Unknown | Assiut University | 60 | 2024-08-30 | 2024-07-17 |
| Perf-Fix Study for Chronic Tympanic Membrane Repair Perf-Fix Otologic Gel Patch - Tympanic Membrane Perforation | Not applicable | Completed | Tympanogen | 71 | 2024-04-05 | 2026-04-16 |
| Microscopic Versus Endoscopic Tympanoplasty Tragal graft tympanoplasty - Tympanic Membrane Perforation | Unknown | Assiut University | 80 | 2024-03-30 | 2024-02-14 | |
| Tympanoseal Clinical Study Tympanoseal - Tympanic Membrane Perforation | Not applicable | Recruiting | Grace Medical, Inc. | 45 | 2024-01-05 | 2024-10-15 |
| Inhalational Anesthesia vs TIVA in Endoscopic Tympanoplasty Isoflurane Inhalant Product, Sevoflurane inhalant product, Propofol injection - Perforated Eardrum | Early Phase 1 | Unknown | Our Lady of the Lake Hospital | 100 | 2023-09-01 | 2023-11-01 |
| Effectiveness of Sequential Eustachian Tube Maneuvers in Hyperbaric Oxygen Conditions Maneuver group - Barotrauma;Ear, Tympanum; Perforation | Not applicable | Recruiting | Hospital Felicio Rocho | 100 | 2023-05-01 | 2026-02-09 |
| Effect of Ventilation Tubes in Otitis-prone Children ventilation tubes - Recurrent Acute Otitis Media | Not applicable | Recruiting | Lund University | 150 | 2022-10-21 | 2023-03-20 |
| Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations FGF-2, Placebo - Tympanic Membrane Perforation | Phase 2 | Completed | NYU Langone Health | 52 | 2022-05-27 | 2026-04-13 |
| Cartilage Versus Temporalis Fascia Graft in Tympanoplasty for Recurrent Tympanic Membrane Perforation '' Comparative Study '' tympanoplasty - Tympanic Membrane Perforation | Unknown | Assiut University | 26 | 2022-04-01 | 2022-03-16 | |
| Effect of Chitodex Gel in Tympanoplasty Surgery Gelfoam, Chitodex - Tympanic Membrane Perforation, Tympanic Membrane Inflammation | Not applicable | Recruiting | Central Adelaide Local Health Network Incorporated | 44 | 2021-11-20 | 2024-11-13 |
Showing 20 of 49. Sign in to see all of them.
Otitis Media (6) · Otitis Media with Effusion (5) · Hearing Loss, Conductive (4) · Cholesteatoma (2) · Otitis Media, Suppurative (2) · Otosclerosis (2) · Pneumococcal Infections (2) · Barotrauma (1) · Cicatrix (1) · Cleft Palate (1) · Hearing Loss (1) · Hearing Loss, Mixed Conductive-Sensorineural (1) · Hearing Loss, Sensorineural (1) · Insulin Resistance (1)
Ear Diseases (49) · Otorhinolaryngologic Diseases (49) · Wounds and Injuries (49) · Otitis (8) · Pathological Conditions, Signs and Symptoms (7) · Hearing Disorders (5) · Nervous System Diseases (5) · Neurologic Manifestations (5) · Sensation Disorders (5) · Signs and Symptoms (5) · Hearing Loss (4) · Infections (4) · Bacterial Infections (2) · Bacterial Infections and Mycoses (2) · Gram-Positive Bacterial Infections (2)
Fibroblast Growth Factor 2 (2) · TachoSil (2) · Tympanoplasty (2) · 23-valent pneumococcal capsular polysaccharide vaccine (1) · Amoxicillin (1) · Anesthesia, General (1) · Anesthesia, Local (1) · Anesthetics, General (1) · Antihypertensive Agents (1) · Boostrix (1) · Bupivacaine (1) · Control Groups (1) · Fibrin Tissue Adhesive (1) · Gelatin Sponge, Absorbable (1) · Insulin (1)
Assiut University (8) · Grace Medical, Inc. (2) · HaEmek Medical Center, Israel (2) · Menzies School of Health Research (2) · Shaikh Zayed Hospital, Lahore (2) · Abd-Elazeem Abd-Elhameed Elbakry (1) · Assistance Publique - Hôpitaux de Paris (1) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (1) · CLOTILDE FUENTES OROZCO (1) · Central Adelaide Local Health Network Incorporated (1) · Combined Military Hospital Quetta (1) · Cook Research Incorporated (1) · D. Bradley Welling, MD, PhD (1) · Deraya University (1) · Duke University (1)
United States (11) · Australia (4) · Pakistan (4) · Egypt (3) · Canada (2) · France (2) · United Kingdom (2) · Brazil (1) · Indonesia (1) · Israel (1) · Mexico (1) · Norway (1) · Slovenia (1) · Sweden (1) · Thailand (1)
Amanda J Leach, PhD (2) · Edward K Mulholland, DM (2) · Jonathan R Carapetis, PhD (2) · Peter S Morris, PhD (2) · Ross M Andrews, PhD (2) · Abd-Elazeem A Elbakry, M.D (1) · Abdelwahab M Rakha (1) · Arnaldo Rivera, M.D. (1) · Christopher Man, MD FRCS(C) (1) · Clotilde Fuentes-Orozco, PhD (1) · D. B. Welling, M.D., Ph.D (1) · David Friedmann, MD (1) · Dennis Frank-Ito, PhD (1) · Hafiz Adil Ikram (1)
PMID 36211411, PMID 12384383, PMID 21217958, PMID 22754796, PMID 25956867, PMID 26529076, PMID 26739478, PMID 29738388, PMID 29937839, PMID 30603376, PMID 32691232, PMID 33993647, PMID 34874794, PMID 37512103, PMID 37870130
2SB1DC018255-02 (1)