10 completed, 6 unknown, 1 active not recruiting, 1 enrolling by invitation. 11 Not applicable, 3 Phase 3, 2 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 5, Unknown 5, Active not recruiting 1 |
| Phase 3 | 3 | Completed 3 |
| Phase 2 | 2 | Completed 2 |
| Phase 1 | 1 | Completed 1 |
Follow Middle Ear Ventilation: new trials by email Literature Review of Middle Ear Ventilation trials Research Report on Middle Ear Ventilation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Balloon Dilation of Eustachian Tube Versus Tympanostomy Tube in Management of Pediatric Obstructive Eustachian Tube Dysfunction eustachian tube dilatation, tympanostomy tube insertion - Otitis Media Effusion | Not applicable | Completed | Mansoura University | 44 | 2025-07-15 | 2026-10-27 |
| Posterior vs. Anterior Tympanostomy Tube Placement Tympanostomy tube - Otitis Media in Children, Chronic Otitis Media With Effusion | Not applicable | Active not recruiting | David Chi, MD | 386 | 2024-02-29 | 2026-02-20 |
| Hearing Improvement After Making a Hole Surgically in Eardrum With or Without Ventilation Tube in Children With Glue Ears Myringotomy with ventilation tube, Myringotomy alone - Otitis Media With Effusion in Children, Hearing Loss | Not applicable | Completed | Allama Iqbal Teaching Hospital | 60 | 2024-01-01 | 2025-04-03 |
| A Prospective, Randomized, Controlled Clinical Study of BET Combined With Tympanostomy Tube Insertion in the Treatment of Intractable OME After Radiotherapy for NPC Balloon Eustachian Tuboplasty with Tympanostomy Tube Insertion, Tympanostomy Tube Insertion - Otitis Media With Effusion After Nasopharyngeal Carcinoma | Not applicable | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 208 | 2022-06-14 | 2022-07-08 |
| Ventilation Tube Insertion for Unilateral Menière's Disease Transmyringeal ventilation tube insertion, Sham-treatment - Meniere Disease | Not applicable | Unknown | Casper Grønlund Larsen | 104 | 2021-09-20 | 2021-10-14 |
| A Non-invasive Device to Remove Fluid From the Middle Ear Non-invasive device for middle ear ventilation - Otitis Media With Effusion | Not applicable | Unknown | Yuinvent Innovations Ltd. | 40 | 2019-07-01 | 2019-06-07 |
| Multi-center:The Small (14F) Percutaneous Catheter vs. Large (28-40F) Open Chest Tube for Traumatic Hemothorax (P-CAT) Percutaneous catheter - The Efficacy of Percutaneous Catheter vs. Open Chest Tube, Traumatic Hemothorax | Not applicable | Completed | University of Arizona | 61 | 2018-03-01 | 2021-05-03 |
| Short-term Effects of Ventilation Tubes in Children With Chronic Otitis Media With Effusion Tympanostomy tube insertion - Otitis Media With Effusion in Children, Quality of Life | Not applicable | Completed | Zealand University Hospital | 60 | 2017-01-20 | 2026-01-16 |
| Allied Cleft & Craniofacial Quality-Improvement and Research Network (ACCQUIREnet) cleft lip repair, cleft palate repair, oronasal fistula repair - Cleft Lip, Cleft Palate | Enrolling by invitation | Duke University | 1000 | 2016-10-01 | 2026-01-07 | |
| Balloon Eustachian Tuboplasty in Treatment of Chronic Eustachian Tube Dysfunction Eustachian tube dilatation device, Myringotomy - Chronic Eustachian Tube Dysfunction, Chronic Recurrent Otitis Media | Not applicable | Completed | University Hospital Ostrava | 55 | 2016-05-01 | 2022-12-07 |
| Pediatric Pharmacokinetic (PK) Study of EXE844 Otic Suspension in Otitis Media at the Time of Tympanostomy Tube Insertion (OMTT) EXE844 Sterile Otic Suspension, 0.3%, Tympanostomy Tube Insertion - Otitis Media With Effusion in Children, Otitis Media Recurrent | Phase 1 | Completed | Alcon Research | 14 | 2015-11-17 | 2018-08-07 |
| Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) EXE844 Sterile Otic Suspension, 0.3%, Tympanostomy Tube Insertion - Otitis Media With Effusion in Children, Otitis Media Recurrent | Phase 3 | Completed | Alcon Research | 470 | 2015-06-25 | 2018-07-02 |
| Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) - Study 2 EXE844 Sterile Otic Suspension, 0.3%, Tympanostomy Tube Insertion - Otitis Media With Effusion in Children, Otitis Media Recurrent | Phase 3 | Completed | Alcon Research | 404 | 2015-06-19 | 2018-07-02 |
| Retrospective Analysis of Perioperative Anesthetic Care and Analgesia Management of Patient Undergoing Bilateral Myringotomy With Tube Insertion Myringotomy with tube insertion - Otitis Media With Effusion (OME) | Withdrawn | Nationwide Children's Hospital | 2015-04-01 | 2016-10-27 | ||
| Efficacy of KNT® (KINETUBE) in Recurrent Chronic Otitis Media in Children KINETUBE medical Device, insertion of tympanic ventilation tubes (tympanostomy) - Chronic Otitis Infections in pédiatric Patients | Not applicable | Unknown | Assistance Publique Hopitaux De Marseille | 140 | 2013-11-01 | 2014-01-16 |
| Device Study to Evaluate the Detection and Characterization of Middle Ear Fluid in Children Myringotomy - Otitis Media With Effusion, Middle Ear Effusion | Not applicable | Unknown | OtoSonics Inc. | 125 | 2011-09-01 | 2011-08-22 |
| The Effect of Obesity on Ventilation Tube Insertion ventilation tube - Otitis Media, Obesity | Unknown | Soonchunhyang University Hospital | 120 | 2010-10-01 | 2011-09-23 | |
| Evaluation of the Tympanostomy Tube Delivery System tympanostomy tube - Otitis Media With Effusion, Acute Otitis Media | Phase 2 / Phase 3 | Completed | Integra LifeSciences Corporation | 53 | 2010-09-01 | 2024-08-06 |
| Adenoidectomy, Myringotomy and Tubes' Insertion vs Adenoidectomy and Myringotomy Alone in Children With Otitis Media With Effusion and Adenoid Hypertrophy adenoidectomy, myringotomy, tubes insertion, A-M - Otitis Media With Effusion | Phase 2 | Completed | Aghia Sophia Children's Hospital of Athens | 52 | 2007-09-01 | 2012-01-23 |
Otitis Media with Effusion (9) · Otitis Media (4) · Cleft Lip (1) · Cleft Palate (1) · Hearing Loss (1) · Hemothorax (1) · Meniere Disease (1) · Nasopharyngeal Carcinoma (1) · Obesity (1) · Vertigo (1) · Wounds and Injuries (1)
Alcon Research (3) · Aghia Sophia Children's Hospital of Athens (1) · Allama Iqbal Teaching Hospital (1) · Assistance Publique Hopitaux De Marseille (1) · Casper Grønlund Larsen (1) · David Chi, MD (1) · Duke University (1) · Integra LifeSciences Corporation (1) · Mansoura University (1) · Nationwide Children's Hospital (1) · OtoSonics Inc. (1) · Soonchunhyang University Hospital (1) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (1) · University Hospital Ostrava (1) · University of Arizona (1)
United States (5) · Denmark (2) · Canada (1) · China (1) · Czechia (1) · Egypt (1) · France (1) · Greece (1) · Pakistan (1)
Alexander C Allori, MD, MPH (1) · Andrew Gould, MD (1) · Charles Syms, MD (1) · David H Chi, MD (1) · Dr. Sharbaz Hussain Khosa, FCPS (1) · Hao Xiong (1) · Ioannis M Vlastos, MD (1) · Jacob Zeiders, MD (1) · Kenneth Faw, MD (1) · Mark E Boseley, MD (1)
PMID 22071915, PMID 23188235, PMID 24375295, PMID 28795207, PMID 29423739, PMID 33843831, PMID 35610739, PMID 36253829, PMID 40008607