43 completed, 7 terminated, 5 unknown, 1 not yet recruiting. 57 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 57 | Completed 43, Terminated 7, Unknown 5, Not yet recruiting 1, Withdrawn 1 |
| Phase 2 | 4 | Completed 3, Withdrawn 1 |
Follow Otitis: new trials by email Literature Review of Otitis trials Research Report on Otitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal Corticosteroid Spray for Preventing Otitis Media With Effusion After Radiotherapy in Nasopharyngeal Carcinoma Triamcinolone Acetonide, Placebo - Otitis Media, Otitis Media With Effusion After Nasopharyngeal Carcinoma | Phase 3 | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 168 | 2025-10-01 | 2025-09-29 |
| Analgesic Ear Drops for Children With Acute Otitis Media lidocaine hydrochloride 5mg/g - Acute Otitis Media, Pain | Phase 3 | Terminated | UMC Utrecht | 29 | 2021-10-06 | 2026-07-16 |
| Effects of 100% Medical Grade Manuka Honey on Tympanic Membrane Reconstruction Healing. Manukamed - Manukapli 100% sterile honey wound dressing - Premium medical grade 16+ Leptospermum Scoparium New Zealand honey - Otitis Media, Suppurative, Tympanic Membrane Perforation | Phase 2 / Phase 3 | Completed | Fakultas Kedokteran Universitas Indonesia | 64 | 2021-06-13 | 2022-11-04 |
| Corticosteroids as an Additional Treatment for Mastoiditis In Children Dexamethasone, normal saline - Mastoiditis; Acute | Phase 3 | Unknown | ori snapiri | 50 | 2021-04-01 | 2021-04-06 |
| V114 and Acute Otitis Media (V114-032/PNEU-ERA) V114, Pediatric vaccines - Acute Otitis Media (AOM) | Phase 3 | Completed | Merck Sharp & Dohme LLC | 7119 | 2020-09-12 | 2026-01-22 |
| Xylitol for Otitis Media Intranasal xylitol spray, Intranasal saline spray - Otitis Media With Effusion | Phase 2 / Phase 3 | Withdrawn | Duke University | 2017-11-20 | 2017-12-22 | |
| In-Office Tympanostomy Tube Placement in Children (OTTER) Iontophoresis & tube placement, Tube placement - OME - Otitis Media With Effusion, AOM - Acute Otitis Media | Phase 3 | Completed | Tusker Medical | 370 | 2017-10-31 | 2022-05-26 |
| Phase III Study Evaluating Topical Benzocaine for Treatment of Acute Otitis Media in Children Benzocaine Otic Solution, Placebo - Pain, Acute Otitis Media | Phase 3 | Completed | Lachlan Pharma Holdings | 141 | 2017-01-03 | 2017-10-13 |
| Improving Knowledge Translation Upon Emergency Department Discharge Video, Pamphlet - Otitis Media | Phase 3 | Completed | Hamilton Health Sciences Corporation | 136 | 2017-01-01 | 2020-08-10 |
| Phase 3 Study of OTO-201 in Acute Otitis Externa 12 mg ciprofloxacin, Sham Control - Acute Otitis Externa, Swimmer's Ear | Phase 3 | Completed | Otonomy, Inc. | 262 | 2016-06-01 | 2020-10-19 |
| Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media Amoxicillin-Clavulanate potassium - Acute Otitis Media | Phase 3 | Completed | Nader Shaikh | 112 | 2015-12-01 | 2018-01-03 |
| Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes OTO-201 (ciprofloxacin) - Otitis Media | Phase 3 | Completed | Otonomy, Inc. | 501 | 2015-10-01 | 2020-10-19 |
| A Study to Compare the Immunogenicity of GSK Biologicals' 10Pn-PD-DiT 4-dose Presentation to the Licensed 1-dose Synflorix™ (10Pn-PD-DiT) Vaccine When Co-administered With DTPw-combination Vaccine in Healthy Infants Pneumococcal vaccine GSK1024850A (10Pn-PD-DiT) vaccine (4-dose presentation), Pneumococcal vaccine GSK1024850A (10Pn-PD-DiT) vaccine (1-dose presentation), DTPw-HBV/Hib - Infections, Streptococcal | Phase 3 | Completed | GlaxoSmithKline | 320 | 2015-06-11 | 2018-08-02 |
| Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media Sinuclean Nebules 45, Saline solution - Otitis Media With Effusion | Phase 3 | Completed | Galsor S.r.l. | 70 | 2015-01-01 | 2016-08-08 |
| Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media AR01, Glycerin ear drops - Acute Otitis Media | Phase 3 | Completed | Arbor Pharmaceuticals, Inc. | 304 | 2013-12-01 | 2015-04-08 |
| Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007) AR01, Placebo Comparator - Acute Otitis Media | Phase 3 | Terminated | Arbor Pharmaceuticals, Inc. | 178 | 2013-12-01 | 2017-01-24 |
| OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement OTO-201, Sham - Otitis Media With Effusion | Phase 3 | Completed | Otonomy, Inc. | 266 | 2013-11-01 | 2016-06-15 |
| OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement OTO-201, Sham - Otitis Media With Effusion | Phase 3 | Completed | Otonomy, Inc. | 266 | 2013-11-01 | 2016-11-11 |
| Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence Herbal-based medication, Placebo - Acute Otitis Media | Phase 3 | Completed | University Hospital Tuebingen | 296 | 2013-10-01 | 2018-05-11 |
| CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study J022X ST, Placebo - Recurrent Upper-Respiratory Tract Infections | Phase 3 | Completed | Pierre Fabre Medicament | 1003 | 2013-09-01 | 2017-02-03 |
Showing 20 of 57. Sign in to see all of them.
Otitis Media (43) · Otitis Media with Effusion (12) · Pneumonia (5) · Otitis Externa (4) · Otitis Media, Suppurative (4) · Pain (4) · Pneumococcal Infections (4) · Respiratory Tract Infections (4) · Streptococcal Infections (4) · Earache (3) · Haemophilus Infections (3) · Pharyngitis (3) · Tympanic Membrane Perforation (3) · Bronchiolitis (2)
Ear Diseases (57) · Otorhinolaryngologic Diseases (57) · Infections (18) · Respiratory Tract Diseases (9) · Otitis Media (8) · Pathological Conditions, Signs and Symptoms (8) · Bacterial Infections (7) · Bacterial Infections and Mycoses (7) · Gram-Positive Bacterial Infections (7) · Lung Diseases (7) · Signs and Symptoms (6) · Neurologic Manifestations (5) · Respiratory Tract Infections (5) · Wounds and Injuries (4)
Ciprofloxacin (5) · Amoxicillin-Potassium Clavulanate Combination (3) · Dexamethasone (3) · Hepatitis A Vaccines (3) · Hepatitis B Vaccines (3) · telithromycin (3) · Amoxicillin (2) · Azithromycin (2) · Benzocaine (2) · Levofloxacin (2) · PHiD-CV vaccine (2) · Saline Solution (2) · salicylhydroxamic acid (2) · 10-valent pneumococcal conjugate vaccine (1) · 13-valent pneumococcal vaccine (1)
Alcon Research (4) · GlaxoSmithKline (4) · Otonomy, Inc. (4) · Sanofi (3) · Arbor Pharmaceuticals, Inc. (2) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (2) · National Institute on Deafness and Other Communication Disorders (NIDCD) (2) · Pfizer (2) · Salvat (2) · Abbott (1) · Boston Children's Hospital (1) · Children's Hospital of Philadelphia (1) · Daiichi Sankyo (1) · Duke University (1) · Fakultas Kedokteran Universitas Indonesia (1)
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Carl LeBel, PhD (3) · Amanda J Leach, PhD (2) · Edward K Mulholland, DM (2) · Jonathan R Carapetis, PhD (2) · Laurence J Downey, MD (2) · Peter S Morris, PhD (2) · Ross M Andrews, PhD (2) · Agricio N. Crespo, Phd (1) · Andrew Gould, MD (1) · April Kam, MD (1)
PMID 26985629, PMID 28006041, PMID 34986178, PMID 36211411, PMID 11172176, PMID 14557958, PMID 17133154, PMID 21576556, PMID 23158882, PMID 23478860, PMID 23658394, PMID 24268590, PMID 24287186, PMID 24394686, PMID 24797294, PMID 25127244, PMID 25788164, PMID 26284652, PMID 26529076, PMID 27125273, PMID 28438923, PMID 29277353, PMID 29299402, PMID 29503110, PMID 30145098, PMID 30184183, PMID 30603376, PMID 31122856, PMID 34024658, PMID 34447389, PMID 36813504, PMID 37479616, PMID 38088821
2008 (2), 2023 (1), R01DC002620 (1), RC1DC010668-01 (1), U01IP000127 (1)