6 completed, 2 terminated, 1 not yet recruiting, 1 recruiting. 4 Phase 2, 3 Phase 3, 1 Not applicable, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 3, Terminated 1 |
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Not applicable | 1 | Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Withdrawn 1 |
Follow Earache: new trials by email Literature Review of Earache trials Research Report on Earache
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Peloid Therapy in Temporomandibular Joint Dysfunction Local Peloid Therapy - Temporomandibular Disorders (TMDs), Pain | Not applicable | Recruiting | Uşak University | 40 | 2026-04-01 | 2026-07-02 |
| Validating and AI Software for Assessment of Children With Ear Concerns Otalgia, Otitis Media | Not yet recruiting | Glimpse Diagnostics, Inc. | 658 | 2026-01-01 | 2025-11-21 | |
| The Effect of Postoperative Eustachian Milking Maneuver on Eustachian Tube Dysfunction Eustachian milking maneuver with routine postoperative treatment protocol, Routine postoperative treatment protocol - Postoperative Middle Ear Pressure, Otalgia | Completed | Karaman Training and Research Hospital | 80 | 2024-10-22 | 2025-04-17 | |
| Interest of Pregabalin (Lyrica) on the Treatment of Reflex Earache in Head and Neck Cancer. Pregabalin, Placebo - Earache | Phase 2 | Terminated | University Hospital, Lille | 42 | 2015-06-05 | 2019-10-14 |
| Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media AR01, Glycerin ear drops - Acute Otitis Media | Phase 3 | Completed | Arbor Pharmaceuticals, Inc. | 304 | 2013-12-01 | 2015-04-08 |
| Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007) AR01, Placebo Comparator - Acute Otitis Media | Phase 3 | Terminated | Arbor Pharmaceuticals, Inc. | 178 | 2013-12-01 | 2017-01-24 |
| Efficacy and Safety of Once-Daily Ciprodexa Otic Foam Compared to Twice-daily Ciprodex Ear Drops in Acute Otitis Externa Ciprodex Otic Suspension, Ciprodexa Otic Foam - Otitis Externa, Otorhinolaryngologic Diseases | Phase 2 | Completed | Otic Pharma | 100 | 2011-07-01 | 2011-11-02 |
| Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro Compared to Twice-Daily Dosing of Ciloxan Ear Drops in Patients With Acute External Otitis 0.3% Ciprofloxacin Ear Drops, FoamOtic Cipro - Otitis Externa, Otorhinolaryngologic Diseases | Phase 2 | Completed | Otic Pharma | 70 | 2010-07-01 | 2011-03-15 |
| Safety and Efficacy Study of Foam Otic Cipro Compared to a Standard Solution ( Ciloxan - Alcon Labs ) to Treat Acute Otitis Externa 0.3% Ciprofloxacin Ear Drops, 0.3% Ciprofloxacin Foam Otic Cipro - Otitis Externa, Otorhinolaryngologic Diseases | Phase 1 / Phase 2 | Completed | Otic Pharma | 100 | 2009-05-01 | 2009-12-24 |
| A Phase III Study of an Otic Formulation in Acute Otitis Externa Moxidex otic solution, Moxifloxacin otic solution, Dexamethasone phosphate otic solution - Acute Otitis Externa | Phase 3 | Completed | Alcon Research | 990 | 2008-06-01 | 2012-12-03 |
| The Study of Eustachian Tube Dysfunction and Laryngopharyngeal Reflux Omeprazole, Ranitidine, Pantoprazole - Eustachian Tube Dysfunction, Laryngopharyngeal Reflux | Phase 4 | Withdrawn | Loma Linda University | 2016-09-26 |
Otitis (6) · Otitis Externa (4) · Ear Diseases (3) · Otitis Media (3) · Otorhinolaryngologic Diseases (3) · Pain (3) · Agnosia (1) · Gastroesophageal Reflux (1) · Laryngopharyngeal Reflux (1) · Neuralgia (1) · Otitis Media with Effusion (1) · Temporomandibular Joint Disorders (1)
Neurologic Manifestations (11) · Pathological Conditions, Signs and Symptoms (11) · Signs and Symptoms (11) · Ear Diseases (8) · Otorhinolaryngologic Diseases (8) · Pain (8) · Nervous System Diseases (2) · Craniomandibular Disorders (1) · Deglutition Disorders (1) · Digestive System Diseases (1) · Esophageal Diseases (1) · Esophageal Motility Disorders (1) · Gastrointestinal Diseases (1) · Jaw Diseases (1) · Joint Diseases (1)
Ciprofloxacin (3) · Benzocaine (2) · Laryngoscopy (1) · Omeprazole (1) · Pantoprazole (1) · Pregabalin (1) · Ranitidine (1)
Otic Pharma (3) · Arbor Pharmaceuticals, Inc. (2) · Alcon Research (1) · Glimpse Diagnostics, Inc. (1) · Karaman Training and Research Hospital (1) · Loma Linda University (1) · University Hospital, Lille (1) · Uşak University (1)
Israel (3) · United States (3) · Turkey (Türkiye) (2) · France (1)
Yehudah Roth, MD (3) · Laurence J Downey, MD (2) · Gilles Lebuffe, MD, PhD (1) · Helen X Xu, MD (1)
2014 (1), R44EB036883 (1)