34 completed, 3 unknown, 2 withdrawn, 1 terminated. 21 Phase 3, 9 Phase 2, 7 Phase 4, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 21 | Completed 20, Unknown 1 |
| Phase 2 | 9 | Completed 8, Withdrawn 1 |
| Phase 4 | 7 | Completed 5, Unknown 1, Withdrawn 1 |
| Phase 1 | 3 | Completed 3 |
Follow PHiD-CV vaccine: new trials by email Literature Review of PHiD-CV vaccine trials Research Report on PHiD-CV vaccine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Post-marketing Safety Evaluation of Pneumococcal Vaccines Among Children and Elderly Adults. 10 or 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine, Influenza vaccine - Pneumococcal Vaccine Adverse Reaction | Unknown | Sungkyunkwan University | 1000000 | 2021-08-01 | 2020-09-16 | |
| Persistence of Immunogenicity Following Reduced PCV Dosing Schedules in South African Children PCV10, PCV13 - Pneumonia, Meningitis | Completed | University of Witwatersrand, South Africa | 600 | 2020-02-14 | 2024-08-23 | |
| Study of 10-valent Pneumococcal Conjugate Vaccine (Pneumosil) Administered in a 2+1 Schedule to Healthy Infants Pneumosil, Prevenar 13, Synflorix - Pneumonia, Pneumococcal | Phase 3 | Completed | PATH | 660 | 2019-07-18 | 2022-04-20 |
| Respiratory Syncytial Virus (RSV) Investigational Vaccine in Infants Aged 6 and 7 Months Likely to be Unexposed to RSV RSV (GSK3389245A) lower dose formulation vaccine, RSV (GSK3389245A) higher dose formulation vaccine, GSK's multicomponent meningococcal B vaccine - Respiratory Syncytial Virus Infections | Phase 1 / Phase 2 | Completed | GlaxoSmithKline | 201 | 2019-04-08 | 2022-07-27 |
| The Effect of Fractional Doses of Pneumococcal Conjugate Vaccines on Immunogenicity and Carriage in Kenyan Infants PCV10, PCV13 - Pneumococcal Infection, Streptococcus Pneumoniae Infection | Phase 4 | Completed | London School of Hygiene and Tropical Medicine | 2100 | 2019-03-21 | 2024-11-12 |
| Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine When Co-administered With Routine Pediatric Vaccines in Healthy Infants and Toddlers in Europe MenACYW conjugate vaccine, Meningococcal group A, C, W-135, and Y conjugate vaccine, DTaP-IPV-HB-Hib vaccine - Meningococcal Infections | Phase 3 | Completed | Sanofi Pasteur, a Sanofi Company | 1660 | 2018-12-14 | 2025-03-03 |
| Phase 3 Study of 10-valent Pneumococcal Conjugate Vaccine (PNEUMOSIL) in Healthy Infants Pneumosil, Synflorix - Pneumonia, Pneumococcal | Phase 3 | Completed | PATH | 2250 | 2017-06-21 | 2020-07-14 |
| Reduced PCV Dosing Schedules in South African Infants Pneumococcal conjugate vaccine (PCV10 ) 1+1, 6 weeks, Pneumococcal conjugate vaccine (PCV10 ) 1+1, 14 weeks, Pneumococcal conjugate vaccine (PCV10 ) 2+1 - Pneumonia, Meningitis | Phase 3 | Completed | University of Witwatersrand, South Africa | 600 | 2017-01-09 | 2019-12-09 |
| Evaluation of PCV Schedules in a Naive Population in Vietnam PCV 2p+1, PCV 3p+0, PCV 1p+1 - Pneumonia, Pneumococcal | Phase 4 | Completed | Nagasaki University | 18652 | 2016-10-01 | 2024-04-19 |
| PCV10 Immunogenicity Study Nepal 2015 10-valent pneumococcal conjugate vaccine - Streptococcus Pneumoniae | Phase 4 | Completed | University of Oxford | 304 | 2015-08-21 | 2018-01-11 |
| A Study to Compare the Immunogenicity of GSK Biologicals' 10Pn-PD-DiT 4-dose Presentation to the Licensed 1-dose Synflorix™ (10Pn-PD-DiT) Vaccine When Co-administered With DTPw-combination Vaccine in Healthy Infants Pneumococcal vaccine GSK1024850A (10Pn-PD-DiT) vaccine (4-dose presentation), Pneumococcal vaccine GSK1024850A (10Pn-PD-DiT) vaccine (1-dose presentation), DTPw-HBV/Hib - Infections, Streptococcal | Phase 3 | Completed | GlaxoSmithKline | 320 | 2015-06-11 | 2018-08-02 |
| Dose-Finding Study of S.Pneumoniae Whole Cell Vaccine Adsorbed to Alum (PATH-wSP) in Healthy Kenyan Adults and Toddlers PATH-wSP, Synflorix, Pentavac - Pneumonia, Pneumococcal | Phase 1 / Phase 2 | Completed | PATH | 304 | 2014-04-01 | 2019-10-10 |
| Trial of Pneumococcal Vaccine Schedules in Ho Chi Minh City, Vietnam PCV10, PCV13 - Pneumococcal Vaccines | Phase 2 / Phase 3 | Completed | Murdoch Childrens Research Institute | 1400 | 2013-09-30 | 2022-09-14 |
| Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Pneumococcal Vaccine (Synflorix™) When Administered to Children Who Are at an Increased Risk of Pneumococcal Infection Synflorix™ - Infections, Streptococcal, Streptococcus Pneumoniae Vaccines | Phase 3 | Completed | GlaxoSmithKline | 52 | 2013-06-18 | 2019-07-09 |
| Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life Prevenar13, Synflorix - Otitis Media, Febrile Illness | Phase 4 | Completed | Menzies School of Health Research | 261 | 2013-03-12 | 2020-03-25 |
| Primary Vaccination With Either Synflorix™ or Prevenar 13™ or Both Vaccines and Booster Vaccination With Synflorix™ Synflorix (3-Dose), Synflorix (2-Dose), Synflorix (Single Dose) - Infections, Streptococcal, Streptococcus Pneumoniae Vaccines | Phase 3 | Completed | GlaxoSmithKline | 457 | 2012-09-04 | 2021-03-02 |
| Immunogenicity and Safety of Two Formulations of GSK Biologicals' Pneumococcal Vaccine (2830929A and 2830930A) When Administered in Healthy Infants Pneumococcal conjugate vaccine GSK2830929A, Pneumococcal conjugate vaccine GSK2830930A, Synflorix™ - Infections, Streptococcal | Phase 2 | Completed | GlaxoSmithKline | 953 | 2012-07-11 | 2019-07-16 |
| Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Pneumococcal Vaccine 2830930A Administered in Toddlers Pneumococcal vaccine GSK2830930A, Synflorix™ - Infections, Streptococcal | Phase 1 | Completed | GlaxoSmithKline | 61 | 2011-12-12 | 2021-02-10 |
| Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children Prevenar 13 and Synflorix - Pneumonia, Meningitis | Phase 3 | Unknown | Papua New Guinea Institute of Medical Research | 200 | 2011-11-01 | 2014-03-21 |
| Pneumococcal Vaccines Early and in Combination Synflorix, Prevenar13, COMBO - Otitis Media | Phase 4 | Completed | Menzies School of Health Research | 425 | 2011-08-01 | 2018-10-18 |
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Streptococcal Infections (18) · Pneumococcal Infections (10) · Haemophilus Infections (8) · Pneumonia (5) · Pneumonia, Pneumococcal (5) · Meningitis (4) · Otitis Media (4) · Diphtheria (2) · Meningococcal Infections (2) · Poliomyelitis (2) · Respiratory Tract Infections (2) · Rotavirus Infections (2) · Tetanus (2) · Toxemia (2) · Anemia, Sickle Cell (1)
GlaxoSmithKline (24) · PATH (3) · Menzies School of Health Research (2) · University of Witwatersrand, South Africa (2) · KEMRI-Wellcome Trust Collaborative Research Program (1) · London School of Hygiene and Tropical Medicine (1) · Murdoch Childrens Research Institute (1) · Nagasaki University (1) · Papua New Guinea Institute of Medical Research (1) · Public Health England (1) · Sanofi Pasteur, a Sanofi Company (1) · Sungkyunkwan University (1) · University of Oxford (1)
Poland (9) · Finland (4) · Germany (4) · Spain (4) · Czechia (3) · Kenya (3) · Mexico (3) · South Korea (3) · The Gambia (3) · United Kingdom (3) · Australia (2) · Italy (2) · Philippines (2) · South Africa (2) · Sweden (2)
Amanda J Leach, PhD (2) · Deborah Lehmann, MSc (1) · Ed Clarke (1) · Ed Clarke, MB ChB, PhD (1) · Edward K Mulholland, MBBS, FRACP (1) · Elizabeth Coates, PhD (1) · J. Anthony G Scott, DTMH FMedSci (1) · Ju-Young Shin, PhD (1) · Laura Hammitt, MD (1) · Nekoye Otsyula, MD (1) · Peter Richmond, MD (1) · Shabir A Madhi, MD PhD (1)
PMID 35772449, PMID 38829821, PMID 14998500, PMID 20686433, PMID 24086113, PMID 24465570, PMID 25596202, PMID 26083474, PMID 29277353, PMID 29299402, PMID 29884695, PMID 30184183, PMID 30635252, PMID 30975525, PMID 32448790, PMID 32857992, PMID 33516293, PMID 33685411, PMID 33745731, PMID 34024658, PMID 34171233, PMID 34447389, PMID 36638819, PMID 36785850, PMID 36934731, PMID 37477875, PMID 37479616, PMID 37780234, PMID 38637212, PMID 39330966, PMID 39417218, PMID 39602629, PMID 39865559, PMID 40665158, PMID 41442837, PMID 42202846, PMID 42710524
2009 (1), 2015 (1), 2017 (1), 2018 (1)