8 completed, 3 terminated, 1 recruiting. 5 Phase 2, 4 Phase 3, 2 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Terminated 1 |
| Phase 3 | 4 | Completed 3, Terminated 1 |
| Not applicable | 2 | Recruiting 1, Terminated 1 |
| Phase 1 | 1 | Completed 1 |
Follow Otitis Externa: new trials by email Literature Review of Otitis Externa trials Research Report on Otitis Externa
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nigella Sativa Oil for Eczematous Otitis Externa Mometasone Furoate (MF), Nigella sativa oil - Eczema/Atopic Dermatitis, Otitis Externa | Not applicable | Recruiting | Bezmialem Vakif University | 85 | 2026-01-12 | 2026-04-21 |
| Performance and Safety of Otinova® Ear Spray Otinova® Ear Spray - Otitis Externa | Not applicable | Terminated | Circius Pharma AB | 28 | 2022-05-01 | 2024-11-15 |
| Phase 3 Study of OTO-201 in Acute Otitis Externa 12 mg ciprofloxacin, Sham Control - Acute Otitis Externa, Swimmer's Ear | Phase 3 | Completed | Otonomy, Inc. | 262 | 2016-06-01 | 2020-10-19 |
| OTO-201 for the Treatment of Otitis Externa OTO-201 (ciprofloxacin) - Otitis Externa | Phase 2 | Completed | Otonomy, Inc. | 75 | 2015-07-01 | 2020-10-19 |
| Non Interventional Clinical Investigation of Ectoin Ear Spray in Skin Treatment of Outer Ear Canal Irritations ear spray - Pruritus, Dermatitis | Completed | Bitop AG | 60 | 2015-06-22 | 2026-01-30 | |
| A Bioequivalence Study of Two Ciprofloxacin/Dexamethasone Formulations in Patients With Otitis Externa Ciprofloxacin/Dexamethasone, Ciprodex (R), Placebo - Otitis Externa | Phase 3 | Terminated | Par Pharmaceutical, Inc. | 455 | 2013-07-01 | 2016-10-18 |
| A Comparative Study Between Two Formulations of the Ciprofloxacin Hydrochloride + Hydrocortisone Otic Suspension Cipro HC, Ciprofloxacin HCl and Hydrocortisone - Otitis Externa | Phase 3 | Completed | Farmoquimica S.A. | 224 | 2012-04-01 | 2015-04-17 |
| Efficacy and Safety of Once-Daily Ciprodexa Otic Foam Compared to Twice-daily Ciprodex Ear Drops in Acute Otitis Externa Ciprodex Otic Suspension, Ciprodexa Otic Foam - Otitis Externa, Otorhinolaryngologic Diseases | Phase 2 | Completed | Otic Pharma | 100 | 2011-07-01 | 2011-11-02 |
| Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro Compared to Twice-Daily Dosing of Ciloxan Ear Drops in Patients With Acute External Otitis 0.3% Ciprofloxacin Ear Drops, FoamOtic Cipro - Otitis Externa, Otorhinolaryngologic Diseases | Phase 2 | Completed | Otic Pharma | 70 | 2010-07-01 | 2011-03-15 |
| Safety and Efficacy Study of Foam Otic Cipro Compared to a Standard Solution ( Ciloxan - Alcon Labs ) to Treat Acute Otitis Externa 0.3% Ciprofloxacin Ear Drops, 0.3% Ciprofloxacin Foam Otic Cipro - Otitis Externa, Otorhinolaryngologic Diseases | Phase 1 / Phase 2 | Completed | Otic Pharma | 100 | 2009-05-01 | 2009-12-24 |
| Topical Voltaren in Otitis Externa diclofenac sodium, dexotc - Otitis Externa | Phase 2 | Terminated | Sieff Medical Center | 20 | 2008-09-01 | 2016-04-20 |
| A Phase III Study of an Otic Formulation in Acute Otitis Externa Moxidex otic solution, Moxifloxacin otic solution, Dexamethasone phosphate otic solution - Acute Otitis Externa | Phase 3 | Completed | Alcon Research | 990 | 2008-06-01 | 2012-12-03 |
Otitis (5) · Earache (4) · Ear Diseases (3) · Otorhinolaryngologic Diseases (3) · Dermatitis (1) · Dermatitis, Atopic (1) · Eczema (1) · Pruritus (1)
Ear Diseases (9) · Otorhinolaryngologic Diseases (9) · Otitis (7) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Neurologic Manifestations (4) · Pain (4) · Skin Diseases (2) · Skin and Connective Tissue Diseases (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Dermatitis (1) · Genetic Diseases, Inborn (1) · Hypersensitivity (1) · Hypersensitivity, Immediate (1) · Immune System Diseases (1)
Ciprofloxacin (7) · Dexamethasone (1) · Diclofenac (1) · Hydrocortisone (1) · Mometasone Furoate (1) · Nigella sativa oil (1) · ciprofloxacin, hydrocortisone drug combination (1)
Otic Pharma (3) · Otonomy, Inc. (2) · Alcon Research (1) · Bezmialem Vakif University (1) · Bitop AG (1) · Circius Pharma AB (1) · Farmoquimica S.A. (1) · Par Pharmaceutical, Inc. (1) · Sieff Medical Center (1)
Israel (4) · United States (3) · Brazil (1) · Canada (1) · Germany (1) · Puerto Rico (1) · Sweden (1) · Turkey (Türkiye) (1)
Yehudah Roth, MD (3) · Carl LeBel, PhD (2) · Agricio N. Crespo, Phd (1) · Chandra S Vattikonda, Ph.D. (1) · Daniel Wilhelms, MD, PhD (1) · Sarah Ohlsson Maleki, MD (1) · Uwe Sonnemann, Dr med (1)