13 not yet recruiting, 8 recruiting, 5 completed, 2 active not recruiting. 15 Not applicable, 4 Phase 3, 4 Phase 4, 3 Phase 2.
Follow Osteo Arthritis of the Knee: new trials by email Literature Review of Osteo Arthritis of the Knee trials Research Report on Osteo Arthritis of the Knee
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis | Phase 2 / Phase 3 | Not yet recruiting | Genascence Corporation | 240 | 2027-07-01 | 2026-09-21 |
| The PERK Study: Predicting and Evaluating Response to Knee RFA Using fNIRS Radiofrequency ablation alone, Genicular Nerve Block - Osteo Arthritis of the Knee, Pain | Not applicable | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 30 | 2026-10-01 | 2026-09-22 |
| A Study to Evaluate Efficacy and Safety of a Single Intra-Articular Injection of HL-01 in the Treatment of Pain in Symptomatic Knee Osteoarthritis Sodium hyaluronate solution - 3.36%, Sterile buffered solution - Osteo Arthritis of the Knee | Phase 3 | Not yet recruiting | IBSA Institut Biochimique SA | 704 | 2026-09-30 | 2026-10-07 |
| Research Title: Long Term Functional Outcome of a Single Hyaluronic Acid Injection in Improving Symptoms and Function in Patients With Knee Osteoarthritis - A Single-Arm Open-Label Study (DIART ONE). Hyaluronic Acid (HA) - Osteo Arthritis of the Knee | Phase 3 | Not yet recruiting | Universiti Sains Malaysia | 62 | 2026-08-30 | 2026-07-30 |
| Comparison of the Effects of Two Different Exercise Programs on Femoral Cartilage Thickness and Clinical Parameters in Individuals With Knee Osteoarthritis Quadriceps Plus Hip Strengthening Exercises, Quadriceps Strengthening Exercises - Osteo Arthritis of the Knee | Not applicable | Not yet recruiting | Pamukkale University | 56 | 2026-08-20 | 2026-06-22 |
| Minimal-Incision Technique With Modified Tracking Pin Placement Versus Standard Robotic-Assisted Total Knee Arthroplasty MISI Robot-Assisted Total Knee Arthroplasty, Standard Robotic-Assisted Total Knee Arthroplasty - Osteo Arthritis of the Knee | Not applicable | Not yet recruiting | Hallym University Kangnam Sacred Heart Hospital | 100 | 2026-08-17 | 2026-08-14 |
| Lubricin-inspired Osteoarthritis Treatment: a Unique Solution ABR1 - Osteo Arthritis of the Knee | Not applicable | Not yet recruiting | Pleryon Therapeutics (Hangzhou) Limited | 25 | 2026-08-01 | 2026-05-29 |
| Manual Arthroplasty Versus VELYS Robotic-Assisted Solution Functional Alignment Arthroplasty for Knee Osteoarthritis Robot-Assisted Functionally Aligned Total Knee Replacement, Manual Total Knee Arthroplasty - Knee Osteoarthritis, Osteoarthritis (Knee) | Not applicable | Recruiting | Golden Jubilee National Hospital | 346 | 2026-07-16 | 2026-09-11 |
| Alignment Techniques in TKA RCT Technology-assisted inverse kinematic alignment TKA, Manual-instrumented gap balancing alignment TKA - Osteo Arthritis of the Knee, Obesity & Overweight | Phase 4 | Not yet recruiting | Jacob M. Elkins | 80 | 2026-07-01 | 2026-06-12 |
| Kinematic vs Mechanical Alignment in High Tibial Osteotomy high tibial osteotomy - Osteo Arthritis of the Knee, Genu Varum | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-06-01 | 2026-05-26 |
| Long Duration High Frequency Ultrasound for the Treatment of Osteoarthritis Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, Intra articular injection - Arthritis, Osteo Arthritis of the Knee | Phase 2 | Not yet recruiting | ZetrOZ, Inc. | 240 | 2026-05-01 | 2026-04-07 |
| Evaluating the Clinical Impact of the Prehabilitation and Recovery for Enabling Potential (PREP) Clinical Care Pathway Osteo Arthritis of the Knee | Not yet recruiting | Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust | 80 | 2026-05-01 | 2026-05-04 | |
| Hydrogel Assessment for Local Treatment of Osteoarthritis Injection of Hydrogel OA 2% - Osteo Arthritis of the Knee | Not applicable | Active not recruiting | Allegro NV/SA | 20 | 2026-04-17 | 2026-07-14 |
| Quadriceps Muscle Quality and Clinical Outcomes in Knee Osteoarthritis Knee Arthritis, Osteoarthritis, Osteo Arthritis of the Knee | Completed | Izmir City Hospital | 60 | 2026-04-14 | 2026-10-01 | |
| Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty Ropivacain 5 mg/ml + Clonidine - Osteo Arthritis of the Knee | Phase 4 | Recruiting | Region Skane | 200 | 2026-03-05 | 2026-05-08 |
| Persona SoluTion PPS Femur PMCF Total knee arthroplasty - Rhematoid Arthritis, Osteo Arthritis of the Knee | Enrolling by invitation | Zimmer Biomet | 200 | 2026-02-26 | 2026-10-06 | |
| Percutaneous Transcatheter Genicular Embolization in Osteoarthritis genicular artery embolisation - Osteoarthritic Knee Pain, Osteo Arthritis of the Knee | Not applicable | Recruiting | Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s. | 20 | 2026-02-02 | 2026-02-04 |
| The Effectiveness of BETY in Knee Osteoarthritis With Intra-Articular Injections BETY - Osteo Arthritis of the Knee, Pain | Not applicable | Recruiting | Hacettepe University | 60 | 2026-01-02 | 2026-03-27 |
| Comparison of Distal IPACK and Popliteal Plexus Block Combined With Femoral Triangle Block After Total Knee Arthroplasty femoral triangle block and popliteal plexus block, Femoral triangle block and distal iPACK - Osteo Arthritis of the Knee | Not applicable | Recruiting | Karaman Training and Research Hospital | 120 | 2025-12-29 | 2026-09-22 |
| Rehabilitation Approaches Used in Total Knee Replacement Questionnaire - Osteo Arthritis of the Knee, Rhematoid Arthritis | Active not recruiting | Bahria University | 384 | 2025-12-10 | 2026-01-29 |
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Osteoarthritis (11) · Osteoarthritis, Knee (7) · Pain (4) · Agnosia (2) · Arthritis (2) · Motor Activity (2) · Obesity (2) · Overweight (2) · Chronic Pain (1) · Collagen Diseases (1) · Diabetes Mellitus, Type 2 (1) · Disease (1) · Genu Varum (1) · Hypertension (1) · Knee Injuries (1)
Joint Diseases (17) · Musculoskeletal Diseases (17) · Arthritis (14) · Rheumatic Diseases (14) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (8) · Neurologic Manifestations (6) · Nervous System Diseases (3) · Osteoarthritis (3) · Behavior (2) · Body Weight (2) · Neurobehavioral Manifestations (2) · Nutrition Disorders (2) · Nutritional and Metabolic Diseases (2) · Overnutrition (2)
Injections, Intra-Articular (2) · Arthroplasty, Replacement, Knee (1) · Clonidine (1) · Diclofenac (1) · Exercise (1) · Exercise Therapy (1) · Fibrin Tissue Adhesive (1) · Hyaluronic Acid (1) · Laser Therapy (1) · Low-Level Light Therapy (1) · Methotrexate (1) · Radiofrequency Ablation (1) · Resistance Training (1) · Saline Solution (1) · Surveys and Questionnaires (1)
Allegro NV/SA (1) · Anchen Pharmaceuticals, Inc (1) · Ankara City Hospital Bilkent (1) · Assiut University (1) · Bahria University (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Genascence Corporation (1) · Golden Jubilee National Hospital (1) · Hacettepe University (1) · Hallym University Kangnam Sacred Heart Hospital (1) · Hospital Civil de Guadalajara (1) · IBSA Institut Biochimique SA (1) · Izmir City Hospital (1) · Jacob M. Elkins (1) · Kafrelsheikh University (1)
Turkey (Türkiye) (4) · United States (4) · United Kingdom (2) · Australia (1) · Bangladesh (1) · Belgium (1) · Canada (1) · Chile (1) · Czechia (1) · Egypt (1) · Malaysia (1) · Mexico (1) · Pakistan (1) · Singapore (1) · South Korea (1)
Andreas Ekman, MD, PhD (1) · Andrew J Hall, PhD, MBChB, MRCS (Ed.) (1) · Azmi Rahman (1) · Charis Lau, PharmD, OD, MBA (1) · Christopher Gee, MSc, FRCS (Tr & Orth), MFSTEd (1) · David Hunter, MD (1) · Eldon Loh, MD (1) · Ivan Patricio Silva-Satlov, Magister (1) · Joanne McGarry (1) · Jon V Clarke, PhD, FRCS (Tr & Orth) (1) · Joong-Il Kim, MD, PhD (1) · Ming Han Lincoln Liow (1)
PMID 13498604, PMID 15639634, PMID 17920940, PMID 20118526, PMID 20175973, PMID 23312414, PMID 23953013, PMID 23980134, PMID 25029916, PMID 25703964, PMID 26528972, PMID 27091650, PMID 27374011, PMID 27518486, PMID 29400369, PMID 31908149, PMID 32380994, PMID 34505846, PMID 35165404, PMID 35768802, PMID 36605849, PMID 37221156, PMID 37346776, PMID 37663162, PMID 38212040, PMID 38669666, PMID 38818397, PMID 4063514, PMID 41185658
2025 (1), R44AG090114 (1)