9 recruiting, 8 not yet recruiting, 5 completed, 2 active not recruiting. 12 Not applicable, 7 Phase 4, 4 Phase 3.
Follow Opioid Consumption, Postoperative: new trials by email Literature Review of Opioid Consumption, Postoperative trials Research Report on Opioid Consumption, Postoperative
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suzetrigine for Analgesiain Arthroscopic Rotator Cuff Repair Suzetrigine (Journavx), Matching placebo, Standard multimodal analgesia - Artroscopic Surgery, Pain Management | Phase 4 | Not yet recruiting | University of Alabama at Birmingham | 100 | 2026-11-01 | 2026-10-08 |
| The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery Lidocaine HCl 0.8% in D5W, Dextrose 5% in water - Pain, Post Operative Analgesia | Phase 4 | Not yet recruiting | Vanderbilt University Medical Center | 2290 | 2026-10-31 | 2026-10-15 |
| Suzetrigine in TKA Placebo, Suzetrigine - Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\) | Phase 3 | Recruiting | Hospital for Special Surgery, New York | 148 | 2026-10-15 | 2026-10-13 |
| Assessing Suzetrigine for Pain Reduction Following Ureteroscopic Surgery multimodal analgesia regimen without suzetrigine, Suzetrigine - Opioid Consumption, Postoperative, Multimodal Analgesia | Phase 3 | Not yet recruiting | Brigham and Women's Hospital | 100 | 2026-10-01 | 2026-09-18 |
| Suzetrigine vs. Standard Care Pain Relief Following Outpatient Knee Replacement Surgery Suzetrigine, Opioid standard care pain medicine - Knee Arthroplasty, Total, Post Operative Pain, Acute | Phase 4 | Not yet recruiting | Endeavor Health | 100 | 2026-09-01 | 2026-09-02 |
| SPSIP Block for Pain Control After Breast Reduction Surgery Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block, Standard Perioperative Pain Treatment - Postoperative Pain Breast Reduction, Mammaplasty | Not applicable | Recruiting | Cumhuriyet University Hospital | 80 | 2026-08-24 | 2026-08-25 |
| Precision Pain Management - A Randomized Clinical Trial Assessing the Efficacy of Suzetrigine on Postoperative Analgesia Among Surgical Patients at Higher Risk for Persistent Postoperative Opioid Use (POU) Suzetrigine, Standard Care (in control arm) - Opioid Consumption, Postoperative | Phase 4 | Recruiting | University of California, San Diego | 100 | 2026-07-02 | 2026-07-06 |
| Transauricular Vagus Nerve Stimulation Frequencies for Postoperative Pain Transauricular Vagus Nerve Stimulation (tVNS), Sham Transauricular Vagus Nerve Stimulation (sham tVNS) - Postoperative Pain, Postoperative Nausea and Vomiting (PONV) | Not applicable | Recruiting | Federal University of Bahia | 174 | 2026-06-01 | 2026-06-10 |
| Suzetrigine for Opioid-Free Recovery After Cesarean Delivery Suzetrigine, Placebo - Cesarean Delivery, Cesarean Section | Phase 4 | Not yet recruiting | University of Texas at Austin | 90 | 2026-06-01 | 2026-04-16 |
| Postoperative Opioid Consumption of Serratus Posterior Superior Intercostal Plane Block Versus Thoracic Paravertebral Block Serratus Posterior Superior Intercostal Plane Block (single injection), Thoracic Paravertebral block (single injection) - Opioid Consumption, Postoperative | Not applicable | Active not recruiting | Zagazig University | 48 | 2026-05-15 | 2026-09-01 |
| Rectus Sheath Block Versus Transversus Abdominis Plane Block for Analgesia in Laparoscopic Bariatric Surgery Rectus Sheath Block, Transversus Abdominis Plane Block - Rectus Sheath Block, Transverse Abdominis Plane Block | Not applicable | Not yet recruiting | Chiang Mai University | 96 | 2026-05-10 | 2026-05-18 |
| Effect of Preoperative Melatonin on Quality of Recovery After Elective Laparoscopic Cholecystectomy Melatonin (N-acetyl-5-methoxytryptamine), Placebo - Laparoscopic Cholecystectomy, Postoperative Quality of Recovery | Not applicable | Recruiting | Armed Forces Medical Institute Bangladesh | 84 | 2026-05-01 | 2026-09-30 |
| Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES) multimodal analgesia pathway with up-front small opioid prescription, multimodal analgesia pathway without up-front small opioid prescription, pre-implementation baseline including opioid - Opioid Consumption, Postoperative, Multimodal Analgesia | Phase 3 | Recruiting | Brigham and Women's Hospital | 300 | 2026-03-01 | 2026-05-22 |
| Dexmedetomidine as an Adjuvant to Bupivacaine for Ultrasound-Guided External Oblique Intercostal Block Dexmedetomidine - Opioid Consumption, Postoperative | Not applicable | Not yet recruiting | Assiut University | 54 | 2025-12-15 | 2025-12-04 |
| Preoperative Opioid Tapering Before Spine Surgery Opioid tapering with CBT and education, Opioid tapering with education alone - Opioid Consumption, Postoperative, Pain After Surgery | Not applicable | Recruiting | Thomas Jefferson University | 45 | 2025-12-01 | 2026-03-24 |
| Suzetrigine in Total Hip Arthroplasty Suzetrigine, Placebo - Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\) | Phase 3 | Recruiting | Hospital for Special Surgery, New York | 210 | 2025-11-03 | 2026-07-30 |
| Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption IV Acetaminophen - Post Operative Analgesia, Opioid Consumption, Postoperative | Phase 4 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 140 | 2025-04-28 | 2025-04-11 |
| Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques Evaluation of the postoperative analgesic effectiveness of PENG block in participants undergoing total hip arthroplasty under spinal anesthesia, Evaluation of the postoperative analgesic effectiveness of lumbar erector spinae block in participants undergoing total hip arthroplasty under spinal anesthesia - Opioid Consumption, Postoperative, Pain, Postoperative | Not applicable | Recruiting | Başakşehir Çam & Sakura City Hospital | 52 | 2025-01-21 | 2026-05-07 |
| Evaluation of the Postoperative Efficacy of Bilateral Lumbar Erector Spinae Plane Block (ESPB) in Patients Undergoing Lumbar Disc Herniation Repair Surgery Opioid Consumption, Postoperative, ESPB | Active not recruiting | Başakşehir Çam & Sakura City Hospital | 78 | 2024-07-01 | 2026-02-11 | |
| Effect of Preoperative Cold Therapy on Early Postoperative Outcomes in Total Knee Arthroplasty Preoperative and Postoperative Cold Therapy with Gel Cold Pack, Postoperative Cold Therapy with Gel Cold Pack - Knee Osteoarthritis, Total Knee Arthroplasty | Not applicable | Completed | Ankara City Hospital Bilkent | 208 | 2024-06-10 | 2025-08-21 |
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Pain, Postoperative (12) · Agnosia (9) · Pain (3) · Anxiety Disorders (1) · Bites and Stings (1) · Depression (1) · Intervertebral Disc Displacement (1) · Opioid-Related Disorders (1) · Osteoarthritis, Knee (1) · Patient Satisfaction (1) · Postoperative Nausea and Vomiting (1) · Prostatic Neoplasms (1) · Vomiting (1)
Neurologic Manifestations (18) · Pathological Conditions, Signs and Symptoms (18) · Signs and Symptoms (18) · Pain (12) · Pathologic Processes (12) · Postoperative Complications (12) · Nervous System Diseases (9) · Neurobehavioral Manifestations (9) · Perceptual Disorders (9) · Behavior (2) · Chemically-Induced Disorders (2) · Musculoskeletal Diseases (2) · Signs and Symptoms, Digestive (2) · Arthritis (1) · Behavioral Symptoms (1)
Lidocaine (2) · Acetaminophen (1) · Analgesics, Opioid (1) · Dexmedetomidine (1) · Educational Status (1) · Glucose (1) · Injections (1) · Melatonin (1) · Sodium Chloride (1) · Standard of Care (1) · Water (1)
Başakşehir Çam & Sakura City Hospital (2) · Brigham and Women's Hospital (2) · Hospital for Special Surgery, New York (2) · Ankara City Hospital Bilkent (1) · Armed Forces Medical Institute Bangladesh (1) · Assiut University (1) · Bursa City Hospital (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Chiang Mai University (1) · Cumhuriyet University Hospital (1) · Endeavor Health (1) · Erasme University Hospital (1) · Federal University of Bahia (1) · The Cleveland Clinic (1) · Thomas Jefferson University (1)
United States (10) · Turkey (Türkiye) (5) · Belgium (2) · Bangladesh (1) · Brazil (1) · Canada (1) · Egypt (1) · Spain (1) · Thailand (1)
Alexandra Sideris, PhD (1) · Danial Shams, MD (1) · Franck Vandenbroucke-Menu, MD (1) · Jean Joris, MD, PhD (1) · Kittitorn Supphapipat, MD (1) · Lorie M. Harper, MD, MSCI (1) · Manuel Murie Fernandez, MD, PhD (1) · Meghan Kirskey, MD (1) · Rodney A Gabriel, MD, MAS (1) · Rodrigo M Vieira, MD (1) · Timothy Clinton, MD (1) · Turgay Tuna, PhD (1)
PMID 25059851, PMID 27501016, PMID 29746445, PMID 29889567, PMID 35312948, PMID 39773549, PMID 40601965, PMID 41345817, PMID 42711072, PMID 9486722
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