12 completed, 9 unknown, 7 recruiting, 6 terminated. 16 Not applicable, 3 Phase 3, 1 Early Phase 1, 1 Phase 2, 1 Phase 4.
Follow Normal Pressure Hydrocephalus: new trials by email Literature Review of Normal Pressure Hydrocephalus trials Research Report on Normal Pressure Hydrocephalus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in Maryland patients will receive NPH education, primary care physicians (PCPs) will receive professional NPH education, A community health worker will assist PCP - Normal Pressure Hydrocephalus, Hakim Syndrome | Not applicable | Not yet recruiting | Johns Hopkins Bloomberg School of Public Health | 660 | 2027-08-01 | 2026-05-07 |
| Prediction of Response to Shunt Surgery in Normal Pressure Hydrocephalus Using Radscale and Lumbar Puncture Idiopathic Normal Pressure Hydrocephalus, Normal Pressure Hydrocephalus | Not yet recruiting | Assiut University | 40 | 2026-10-01 | 2026-09-22 | |
| Non-invasive Diagnostics of Shunt Obstruction in Adult Hydrocephalus Intervention group "Virtual OFF", Control group (no change in shunt setting) - Normal Pressure Hydrocephalus Patients, Normal Pressure Hydrocephalus | Not applicable | Not yet recruiting | Göteborg University | 60 | 2025-09-15 | 2025-09-15 |
| Analysis of Cerebrospinal Fluid Dynamics in Normal Pressure Hydrocephalus Cerebrospinal fluid drainge - Normal Pressure Hydrocephalus | Not applicable | Recruiting | Chungnam National University Hospital | 22 | 2025-09-11 | 2026-09-21 |
| White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH) Ventriculoperitoneal Shunt (VP), Brain and Skin Biopsy, MRI Brain - Normal Pressure Hydrocephalus | Recruiting | Imperial College London | 100 | 2025-03-25 | 2026-03-27 | |
| Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus CereVasc eShunt System, VP Shunt - Normal Pressure Hydrocephalus | Not applicable | Active not recruiting | CereVasc Inc | 230 | 2024-11-26 | 2026-06-25 |
| Proteinopathies Expression in Skin of Neurodegenerative Disorders Immunohistochemistry and immunofluorescence - Alzheimer Disease, Frontotemporal Dementia | Recruiting | Universidad Autonoma de San Luis Potosí | 40 | 2023-12-20 | 2024-12-16 | |
| European Study of Prodromal iNPH Shunt surgery - Normal Pressure Hydrocephalus, Hydrocephalus | Recruiting | Johan Virhammar | 140 | 2023-11-01 | 2026-04-30 | |
| Neurosurgical Outcome Network Aneurysms, Arteriovenous Malformations | Recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 4500 | 2022-12-05 | 2026-03-30 | |
| Normal Pressure Hydrocephalus Biomarkers Investigation Measurement of oxysterol profile, including 20 molecules, in liquor before and after surgery - Normal Pressure Hydrocephalus, Cognitive Impairment | Unknown | University of Roma La Sapienza | 30 | 2022-10-30 | 2022-10-03 | |
| The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH Hydrocephalus, Normal Pressure Hydrocephalus | Completed | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 29 | 2021-06-15 | 2026-02-11 | |
| Identifying Gait Changes From a CSF Tap Test Using a Smart Insole in iNPH Normal Pressure Hydrocephalus | Recruiting | Yonsei University | 50 | 2021-06-01 | 2024-12-09 | |
| Normal Pressure Hydrocephalus and Sleep Apnea CSF shunt diversion - Normal Pressure Hydrocephalus, Sleep Apnea | Not applicable | Recruiting | University of Valencia | 30 | 2020-07-02 | 2026-04-22 |
| A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies Biomarker assay - Parkinson Disease, Multiple System Atrophy | Terminated | Stony Brook University | 8 | 2020-01-15 | 2025-04-06 | |
| Adjustable Gravitational vs. Adjustable Differential Pressure Valves in iNPH MIETHKE M.blue®, MIETHKE proGAV 2.0® (with SA 2.0®) - Normal Pressure Hydrocephalus | Not applicable | Unknown | Military University Hospital, Prague | 40 | 2020-01-01 | 2020-06-16 |
| Effect of Depletive Lumbar Puncture on Lower Urinary Tract Dysfunction in iNPH Urinary symptoms profile questionnaire, Micturition calendar - Normal Pressure Hydrocephalus | Not applicable | Unknown | EssaiClinique_PL-HPN | 100 | 2019-03-13 | 2019-03-19 |
| Brain Network Activation in Patients With Movement Disorders Parkinson Disease, Essential Tremor | Unknown | Sheba Medical Center | 300 | 2019-03-01 | 2021-03-19 | |
| Neurology Inpatient Clinical Education Trial Current standard discharge educational intervention, Personalized discharge educational intervention - Myasthenia Gravis, Guillain-Barre Syndrome | Not applicable | Completed | Dartmouth-Hitchcock Medical Center | 50 | 2019-02-01 | 2022-01-11 |
| CPT-3 in Normal Pressure Hydrocephalus Conner's Continuous Performance Test-3 - Normal Pressure Hydrocephalus | Terminated | Vanderbilt University Medical Center | 8 | 2019-01-16 | 2023-07-27 | |
| Acetazolamide for Treating NPH in Shunt-candidates Patients Acetazolamide - Normal Pressure Hydrocephalus | Phase 2 | Unknown | Rabin Medical Center | 15 | 2018-12-01 | 2018-12-19 |
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Hydrocephalus, Normal Pressure (39) · Hydrocephalus (12) · Dementia (4) · Alzheimer Disease (3) · Parkinson Disease (3) · Multiple System Atrophy (2) · Parkinsonian Disorders (2) · Tremor (2) · Amyotrophic Lateral Sclerosis (1) · Aneurysm (1) · Arteriovenous Malformations (1) · Ataxia (1) · Camurati-Engelmann Syndrome (1) · Cerebellar Ataxia (1) · Cognitive Dysfunction (1)
Brain Diseases (39) · Central Nervous System Diseases (39) · Nervous System Diseases (39) · Hydrocephalus (27) · Mental Disorders (11) · Neurocognitive Disorders (9) · Pathological Conditions, Signs and Symptoms (7) · Neurodegenerative Diseases (6) · Movement Disorders (5) · Signs and Symptoms (5) · Basal Ganglia Diseases (4) · Dementia (4) · Musculoskeletal Diseases (3) · Neurologic Manifestations (3) · Neuromuscular Diseases (3)
Ventriculoperitoneal Shunt (3) · Hydrodynamics (2) · flutemetamol (2) · Acetazolamide (1) · Cerebrovascular Circulation (1) · Control Groups (1) · Fluorescent Antibody Technique (1) · Immunohistochemistry (1) · Occupational Therapy (1) · Physical Therapy Modalities (1) · Physicians, Primary Care (1) · Speech Therapy (1) · Spinal Puncture (1) · Surgical Procedures, Operative (1) · Ventriculostomy (1)
Centre Hospitalier Universitaire, Amiens (2) · Codman & Shurtleff (2) · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (2) · GE Healthcare (2) · Johns Hopkins University (2) · Umeå University (2) · Vanderbilt University Medical Center (2) · Assiut University (1) · CereVasc Inc (1) · Chungnam National University Hospital (1) · Dartmouth-Hitchcock Medical Center (1) · EssaiClinique_PL-HPN (1) · Göteborg University (1) · Imperial College London (1) · International Neuroscience Institute Hannover (1)
United States (14) · France (4) · Italy (4) · Sweden (3) · Czechia (2) · Germany (2) · Israel (2) · South Korea (2) · United Kingdom (2) · Argentina (1) · Canada (1) · China (1) · Denmark (1) · Finland (1) · Mexico (1)
Kim A Mansfield, MS (2) · Anders Behrens, M.D., M.Sc. (1) · Anthony Marmarou, Ph.D. (1) · Carine W. Maurer, MD, PhD (1) · Carsten I Wikkelsoe, MD (1) · Daniele Rigamonti, MD (1) · Daniele Rigamonti, MD FACS (1) · Gianpaolo Petrella, M.D. (1) · Hossein Zare, PhD (1) · J. Thomas Megerian, MD (1) · James E Eaton, MD (1) · Jennifer Lu (1) · Jing Gao, MD (1)
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