10 completed, 7 unknown, 5 not yet recruiting, 4 recruiting. 8 Phase 4, 7 Not applicable, 3 Phase 2, 1 Phase 1, 1 Phase 3.
Follow No-Reflow Phenomenon: new trials by email Literature Review of No-Reflow Phenomenon trials Research Report on No-Reflow Phenomenon
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating SGLT2 Inhibitors for the Reduction of No-Reflow Phenomenon in Patients Undergoing PCI Empagliflozin (SGLT2i), dapagliflozin, Standard medical treatment - No Reflow Phenomenon, Reperfusion Injuries, Myocardial | Phase 2 | Not yet recruiting | Al-Azhar University | 100 | 2027-01-01 | 2026-10-27 |
| Insulin Resistance and Its Association With no Reflow Phenomenon After Primary PCI in Type II Diabetic STEMI Patients. PCI - STEMI, No-Reflow Phenomenon | Not yet recruiting | Assiut University | 100 | 2026-08-01 | 2026-07-16 | |
| Rivaroxaban for Slow Coronary Flow After PCI in STEMI Dual Antiplatelet (DAPT) Therapy, Rivaroxaban - ST Elevation Myocardial Infarction, No-Reflow Phenomenon | Phase 4 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 60 | 2025-10-01 | 2025-09-29 |
| Validation of New Biomarkers for Predicting No-Reflow in STEMI Patients Undergoing Primary PCI HbA1c/C-peptide ratio Albumin-bilirubin (ALBI) score. Neutrophil/HDL ratio - Myocardial Infarction, No Reflow Phenomenon | Not yet recruiting | Assiut University | 114 | 2025-09-01 | 2025-08-29 | |
| Investigation of Brain Blood Flow Changes in Acute Ischemic Stroke Patients After Successful Endovascular Thrombectomy No planned intervention - Acute Cerebrovascular Accident, Thrombectomy | Recruiting | University of Zurich | 100 | 2025-06-01 | 2026-04-16 | |
| Adenosine Pre-Medication in Primary Percutaneous Coronary Intervention Adenosine pre-medication, Standard care - ST-Segment Elevation Myocardial Infarction (STEMI), No-Reflow Phenomenon | Phase 4 | Recruiting | National Institute of Cardiovascular Diseases, Pakistan | 1148 | 2025-06-01 | 2026-04-22 |
| Empagliflozin for No-reflow Phenomenon in PCI for STEMI Empagliflozin 25 milgrams (Mg), Empagliflozin 10 Mg - STEMI, No-Reflow Phenomenon | Phase 2 | Active not recruiting | Instituto Nacional de Cardiologia Ignacio Chavez | 162 | 2024-08-22 | 2026-04-15 |
| The Investigator Administers Intracoronary Adrenaline Via the Catheter in STEMI Patients During Primary PCI, After Flow Restoration and Before Stenting, and Studies Its Effect in Prevention of No Reflow Adrenaline - ST Segment Elevation Myocardial Infarction (STEMI), No Reflow Phenomenon | Phase 3 | Recruiting | Ain Shams University | 1000 | 2024-04-01 | 2025-03-11 |
| Oral Nicorandil for Prevention of No Reflow Phenomenon in Anterior STEMI Patients Undergoing PPCI Nicorandil 20mg - No Reflow Phenomenon, Anterior STEMI | Phase 1 / Phase 2 | Completed | Ain Shams University | 300 | 2024-03-10 | 2025-08-24 |
| Upfront Premedication For Reduction of Microvascular Obstruction and No-reflow in Treating ST-segment Elevation Myocardial Infarction Upfront preparation of microcirculation to minimize risks of no-reflow and reperfusion injury - STEMI, Large Thrombus Burden | Not applicable | Not yet recruiting | Cairo University | 626 | 2024-01-01 | 2023-08-31 |
| A Study to Evaluate the Impact of Pre-procedural Intracoronary Nicorandil Injection to PREVENT reductioN Of decREased TIMI FLOW in Patients Who Undergoing Percutaneous Coronary Intervention for the Coronary Artery Disease Nicorandil - No-Reflow Phenomenon, Coronary Artery Disease | Phase 4 | Recruiting | Korea University Anam Hospital | 458 | 2022-12-14 | 2026-09-08 |
| Genetic Determinants of the Coronary Microvascular Obstruction in PCI different variants of SNPs that may be associated with the coronary microvascular obstruction development - Myocardial Infarction, No-Reflow Phenomenon | Completed | Privolzhsky Research Medical University | 80 | 2022-04-11 | 2026-02-17 | |
| Alpha Lipoic Acid Effect on No-Reflow Phenomenon Alpha Lipoic Acid plus the standard care for post-PCI MI, The standard care for post-PCI MI - No-Reflow Phenomenon | Not applicable | Completed | Ain Shams University | 70 | 2022-01-01 | 2024-11-05 |
| the No-reflow in Diabetic Patients Treated With Primary Percutaneous Coronary Intervention (PCI) 1- LDL-C (low-density lipoprotein cholesterol)| and HDL-C(high-density lipoprotein cholesterol) Ratio. 2- Glycemia will be assessed : RBS ( random blood sugar ) . 3- S - No-Reflow Phenomenon | Not applicable | Unknown | Assiut University | 120 | 2021-05-01 | 2021-04-14 |
| Adrenaline for the Treatment of No-Reflow in Normotensive Patients Adrenaline, Adenosine - Acute Coronary Syndrome, No-Reflow Phenomenon | Phase 4 | Completed | National Institute of Cardiovascular Diseases, Pakistan | 201 | 2021-01-01 | 2021-05-21 |
| The EPIVER Randomized Controlled Trial Standard therapy, Epinephrine, Verapamil - ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention | Not applicable | Completed | Tomsk National Research Medical Center of the Russian Academy of Sciences | 104 | 2020-12-30 | 2026-06-24 |
| Mean Platelet Volume and STEMI Clinical Risk Scores in Prediction of Impaired Myocardial Perfusion In Acute STEMI Patients Undergoing Primary Percutaneous Coronary Intervention. Mean platelet volume, lymphocyte number, STEMI clinical risk scores - No-Reflow Phenomenon | Completed | Assiut University | 640 | 2020-09-01 | 2024-05-31 | |
| Empagliflozin on Cardiac-renal Injury in Patients With STEAMI Patients After Primary PCI Empagliflozin, placebo - Reperfusion Injury, Myocardial | Not applicable | Unknown | Chinese PLA General Hospital | 128 | 2018-10-01 | 2018-07-19 |
| NGAL and Its Association With the No-reflow Phenomenon in ST-elevation Myocardial Infarction NGAL levels early and post STEMI - No-Reflow Phenomenon, STEMI - ST Elevation Myocardial Infarction | Unknown | Sheba Medical Center | 100 | 2017-09-15 | 2017-08-29 | |
| Evaluation of Emotional Status and Coronary Flow Characteristics by TIMI Frame Count Method coronary angiography - Coronary Artery Disease, Coronary Artery Ectasia | Not applicable | Unknown | Ertan YETKIN | 2000 | 2016-07-01 | 2016-07-13 |
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ST Elevation Myocardial Infarction (10) · Myocardial Infarction (6) · Coronary Artery Disease (5) · Coronary Aneurysm (2) · Coronary Disease (2) · Myocardial Reperfusion Injury (2) · Reperfusion Injury (2) · Acute Coronary Syndrome (1) · Anxiety Disorders (1) · Depression (1) · Ischemic Stroke (1) · Stroke (1)
Ischemia (27) · Pathologic Processes (27) · Pathological Conditions, Signs and Symptoms (27) · Cardiovascular Diseases (22) · Vascular Diseases (22) · Heart Diseases (21) · Myocardial Ischemia (21) · Infarction (15) · Necrosis (15) · Myocardial Infarction (9) · Arterial Occlusive Diseases (5) · Arteriosclerosis (5) · Coronary Disease (3) · Postoperative Complications (3) · Aneurysm (2)
Epinephrine (3) · empagliflozin (3) · Clopidogrel (2) · Nicorandil (2) · Standard of Care (2) · Tirofiban (2) · Verapamil (2) · 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine (1) · Adenosine (1) · Aspirin (1) · Dietary Supplements (1) · Diltiazem (1) · Evoked Potentials, Visual (1) · Injections (1) · Lymphocyte Count (1)
Assiut University (4) · Ain Shams University (3) · Fudan University (2) · National Institute of Cardiovascular Diseases, Pakistan (2) · Al-Azhar University (1) · Cairo University (1) · Chinese PLA General Hospital (1) · Ertan YETKIN (1) · First Hospital of China Medical University (1) · Hull University Teaching Hospitals NHS Trust (1) · Instituto Nacional de Cardiologia Ignacio Chavez (1) · Korea University Anam Hospital (1) · Privolzhsky Research Medical University (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Sheba Medical Center (1)
Egypt (5) · China (3) · Turkey (Türkiye) (3) · Pakistan (2) · Russia (2) · Germany (1) · Israel (1) · Mexico (1) · South Korea (1) · Switzerland (1) · United Kingdom (1)
Junbo Ge, M.D. (2) · Ahmad Samir (1) · Ayman M Saleh, MD (1) · Eduardo Arias-Sanchez, MD (1) · Hossam H. Ali (1) · Ilya Pochinka, MD (1) · Jennifer A Rossington, BSc MBChB (1) · Jorn Fierstra, Prof Dr. med., PhD (1) · Jun Jiang, Doctor (1) · Lamiaa M El Wakeel, PhD (1) · Marwa Adel Ahmed, PhD (1) · Muhammad Nauman, FCPS (1) · Petra Kleinbongard, PhD (1) · Shlomi Matetzky, Prof. (1)
PMID 22980307, PMID 23305356, PMID 25915510, PMID 30992077, PMID 31127491, PMID 31759100, PMID 31779619, PMID 32396609, PMID 32539724, PMID 32717242, PMID 34712142, PMID 34896968, PMID 35000456, PMID 35705980, PMID 40846132, PMID 41230400, PMID 41426969