6 completed, 4 terminated, 2 withdrawn, 1 active not recruiting. 15 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Completed 6, Terminated 4, Withdrawn 2, Active not recruiting 1, Not yet recruiting 1, Unknown 1 |
| Phase 1 | 2 | Active not recruiting 1, Completed 1 |
Follow Neuropathy: new trials by email Literature Review of Neuropathy trials Research Report on Neuropathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NeuroGuard: Psilocybin Trial for Preventing Chemo-induced Neuropathy Psilocybin (drug), Standard of Care (SOC) - Psilocybin, Neuropathy | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 83 | 2026-11-04 | 2026-10-05 |
| SPI-1005 for Prevention and Treatment of Chemotherapy Induced Hearing Loss SPI-1005 Low Dose, SPI-1005 Middle Dose, SPI-1005 High Dose - Lung Cancer, Head and Neck Cancer | Phase 2 | Withdrawn | Sound Pharmaceuticals, Incorporated | 2026-06-01 | 2026-06-03 | |
| BXQ-350 in Newly Diagnosed Metastatic Colorectal Carcinoma BXQ-350, Placebo - Metastatic Colorectal Carcinoma, Neuropathy | Phase 1 / Phase 2 | Active not recruiting | Bexion Pharmaceuticals, Inc. | 195 | 2023-01-09 | 2026-09-29 |
| Study of Nicotine for Pain Associated With Chemotherapy-Induced Peripheral Neuropathy Nicotine Transdermal Patch - Neuropathy, Peripheral Neuropathy | Phase 2 | Terminated | Virginia Commonwealth University | 4 | 2020-07-31 | 2023-11-08 |
| The Effect of Lacosamide in Peripheral Neuropathic Pain Lacosamide, Placebo - Neuropathic Pain, Neuropathy;Peripheral | Phase 2 | Terminated | Danish Pain Research Center | 63 | 2019-01-15 | 2023-02-16 |
| The Efficacy and Safety of Clonidine Hydrochloride Topical Gel, vs Clonidine Hydrochloride Gel Comparator to Treat Painful Diabetic Neuropathy Clonidine Hydrochloride Topical Gel, 0.1%, Clonidine Hydrochloride Gel Comparator - Painful Diabetic Neuropathy, Diabetic Neuropathy | Phase 2 | Completed | BioDelivery Sciences International | 138 | 2015-12-01 | 2017-09-20 |
| Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Pain Associated With Diabetic Neuropathy Clonidine Gel 0.1%, Placebo - Painful Diabetic Neuropathy, Diabetic Neuropathy | Phase 2 | Completed | BioDelivery Sciences International | 260 | 2014-03-01 | 2017-09-26 |
| Topical Menthol for the Treatment of Chemotherapy Induced Peripheral Neuropathy topical menthol, placebo lotion - Breast Cancer, Colon Cancer | Phase 2 | Terminated | Columbia University | 12 | 2013-08-01 | 2024-07-11 |
| The Arterial Measurement of the Blood Flow Volume After Iloprost Stimulation Ilomedin - Diabetes, Arteriosclerosis | Phase 2 | Unknown | Prim PD Dr Afshin Assadian | 100 | 2012-10-01 | 2018-10-17 |
| Eribulin in Combination With Cyclophosphamide in Patients With Solid Tumor Malignancies Eribulin, Cyclophosphamide - Malignant Solid Tumour, Breast Cancer Nos Metastatic Recurrent | Phase 1 / Phase 2 | Completed | University of California, San Francisco | 44 | 2012-03-27 | 2021-02-03 |
| Therapeutic Interventions For Pain Induced By Vincristine Treatment For Childhood Acute Lymphoblastic Leukemia (ALL) gabapentin, placebo - Acute Lymphoblastic Leukemia, Neuropathy | Phase 2 | Completed | St. Jude Children's Research Hospital | 51 | 2012-01-24 | 2019-06-19 |
| Safety and Preliminary Evidence of Efficacy of Escalating Doses of Dimiracetam in AIDS Patients With Painful Neuropathy dimiracetam, sugar pill - Neuropathy, AIDS | Phase 2 | Completed | Neurotune AG | 116 | 2009-10-01 | 2010-06-02 |
| Study of Lenalidomide as a Treatment for Neuropathy Associated With Monoclonal Gammopathy of Undetermined Significance Lenalidomide - Neuropathy, Nonmalignant Monoclonal Gammopathy of Undetermined Significance (MGUS) | Phase 2 | Terminated | Dartmouth-Hitchcock Medical Center | 8 | 2008-04-01 | 2018-09-11 |
| Epoetin Alfa for HIV-Associated Neuropathy Trial epoetin alfa - HIV Infections, Neuropathy | Phase 2 | Withdrawn | Washington University School of Medicine | 2007-11-01 | 2011-08-09 | |
| A Comparison of EpiCept™ NP-1 Topical Cream vs. Oral Gabapentin in Postherpetic Neuralgia (PHN) EpiCept-NP-1 Cream, Gabapentin Capsules, placebo - Post Herpetic Neuralgia, PHN | Phase 2 | Completed | EpiCept Corporation | 360 | 2007-07-01 | 2011-07-27 |
Neuralgia (5) · Diabetes Mellitus (3) · Diabetic Neuropathies (3) · Acquired Immunodeficiency Syndrome (2) · Breast Neoplasms (2) · Pain (2) · Arteriosclerosis (1) · Carcinoma (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Deafness (1) · HIV Infections (1) · Head and Neck Neoplasms (1) · Hearing Loss (1) · Lung Neoplasms (1)
Nervous System Diseases (8) · Neurologic Manifestations (8) · Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (8) · Neuromuscular Diseases (7) · Peripheral Nervous System Diseases (6) · Neoplasms (5) · Pain (5) · Endocrine System Diseases (4) · Neoplasms by Site (4) · Diabetes Complications (3) · Glucose Metabolism Disorders (3) · Immune System Diseases (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3)
Gabapentin (2) · Cyclophosphamide (1) · Epoetin Alfa (1) · Erythropoietin (1) · Injections (1) · Lacosamide (1) · Lenalidomide (1) · Menthol (1) · Pharmaceutical Preparations (1) · Psilocybin (1) · Solvents (1) · Standard of Care (1) · Sugars (1) · Tobacco Use Cessation Devices (1) · dimiracetam (1)
BioDelivery Sciences International (2) · Bexion Pharmaceuticals, Inc. (1) · Columbia University (1) · Danish Pain Research Center (1) · Dartmouth-Hitchcock Medical Center (1) · EpiCept Corporation (1) · M.D. Anderson Cancer Center (1) · Neurotune AG (1) · Prim PD Dr Afshin Assadian (1) · Sound Pharmaceuticals, Incorporated (1) · St. Jude Children's Research Hospital (1) · University of California, San Francisco (1) · Virginia Commonwealth University (1) · Washington University School of Medicine (1)
United States (10) · Austria (1) · Denmark (1) · India (1) · South Africa (1)
Aziz Shaibani, MD (2) · Afshin Assadian, Prim PD Dr (1) · Bruce Cohen, MD (1) · Daniel R Malan, MD (1) · David B. Clifford, MD (1) · David Simpson, MD (1) · Dawn Hershman, MD (1) · Doralina Anghelescu, MD (1) · Elijah W. Stommel, MD, PhD (1) · Hope S Rugo, MD (1) · Jonathan Kil, MD (1) · Justin McArthur, MBBS, MPH (1) · Moran Amit, MD (1) · Nanna B Finnerup, Professor (1)
PMID 31604475, PMID 35587172, PMID 37815684
2018 (1), U01NS032228 (1)