134 completed, 30 unknown, 19 terminated, 10 not yet recruiting. 210 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 210 | Completed 134, Unknown 30, Terminated 19, Not yet recruiting 10, Withdrawn 8, Recruiting 7, Active not recruiting 1, Enrolling by invitation 1 |
Follow Nausea: new trials by email Literature Review of Nausea trials Research Report on Nausea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Broadening Antiemetics Research by Comparing the Effectiveness of Fosaprepitant and Metoclopramide Fosaprepitant for Injection, Metoclopramide Injection - Nausea and Vomiting, Nausea | Phase 4 | Not yet recruiting | Montefiore Medical Center | 212 | 2026-12-01 | 2026-06-29 |
| Effect of Ketamine-Propofol Total Intravenous Anesthesia Versus Sevoflurane-Based Anesthesia on Postoperative Vomiting in Children Undergoing Strabismus Surgery Ketamine and Propofol, Sevoflurane - Postoperative Vomiting, Postoperative Nausea and Vomiting | Phase 4 | Not yet recruiting | Assiut University | 50 | 2026-11-01 | 2026-10-13 |
| Study to Assess Safety and Tolerability of KarXT With Administration of Antiemetics in Healthy Volunteers KarXT, Trimethobenzamide, Ondansetron - Healthy Volunteers | Phase 4 | Recruiting | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 180 | 2026-09-03 | 2026-10-15 |
| Time to First Rescue Antiemetic With Ondansetron Plus Metoclopramide Versus Dexamethasone Plus Metoclopramide for PONV Prophylaxis in Laparoscopic Cholecystectomy ondansetron 4 mg, Dexamethasone (intravenous), Metoclopramide 10mg - Postoperative Nausea and Vomiting | Phase 4 | Recruiting | Faisalabad Medical University | 264 | 2026-09-01 | 2026-09-04 |
| Sleep Quality - Comparing the Effect of Ondansetron or Dexamethasone Given as Routine Prophylaxis Intraoperatively to Prevent Post Operative Nausea and Vomiting (SCORPION) Dexamethasone (IV), Ondansetron iv - Postoperative Sleep Quality, Postoperative Behaviour | Phase 4 | Not yet recruiting | Telethon Kids Institute | 500 | 2026-08-17 | 2026-08-20 |
| A Randomized Controlled Trial Comparing the Effects of Different Anesthetic Sedatives on PONV in Laparoscopic Cholecystectomy Propofol, Ciprofol, Remimazolam - Cholelithiasis, Postoperative Nausea and Vomiting | Phase 4 | Completed | Xi'an Aerospace General Hospital | 114 | 2026-08-15 | 2026-11-10 |
| Aprepitant to Improve Same Day Discharge for TKA Aprepitant Injection, Ondansetron (Zofran), Dexamethasone - PONV | Phase 4 | Not yet recruiting | Endeavor Health | 350 | 2026-07-01 | 2026-06-10 |
| Effect of Aprepitant on Post-operative Nausea and Vomiting in Otologic Surgery Aprepitant, Placebo - Otologic Disease | Phase 4 | Not yet recruiting | Sir Mortimer B. Davis - Jewish General Hospital | 100 | 2026-06-01 | 2026-01-28 |
| Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery Dexmedetomidine, Standard General Anesthesia - Thyroid Diseases | Phase 4 | Recruiting | Bach Mai Hospital | 100 | 2026-04-13 | 2026-04-15 |
| General Anaesthesia vs Spinal Anaesthesia: Patient Outcomes and Success in Outpatient Primary Total Knee and Hip Arthroplasty General Anaesthesia, Spinal Anesthesia (bupivacaine) - Osteo Arthritis Knee and Hip, Osteo Arthritis | Phase 4 | Not yet recruiting | Region Örebro County | 600 | 2026-04-01 | 2026-01-12 |
| Granisetron Combined With Dexamethasone or Metoclopramide for PONV Prevention After Laparoscopic Cholecystectomy Granisetron - Postoperative Nausea and Vomiting (PONV) | Phase 4 | Not yet recruiting | Assiut University | 102 | 2026-03-01 | 2026-01-22 |
| Spinal Morphine and Atropine Added to General Anaesthesia for Nausea and Pain After Abdominal Laparoscopy Intrathecal bupivacaine, morphine and atropine, General anaesthesia, Multimodal analgesia and antiemetic prophylaxis - Postoperative Nausea and Vomiting, Postoperative Pain | Phase 4 | Completed | Universitas Indonesia | 63 | 2026-02-02 | 2026-10-01 |
| Steroids for Rhinoplasty: Pain, Nausea, Edema and Ecchymosis Medrol 4 MG Oral Tablet Includes Medrol Dosepak - Edema, Bruising | Phase 4 | Withdrawn | Vanderbilt University Medical Center | 2026-01-01 | 2025-11-18 | |
| Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy Ondansetron Intraperitoneal Lavage, Saline Intraperitoneal Lavage - Postoperative Pain Management, Laparoscopic Cholecystectomy | Phase 4 | Active not recruiting | Instituto Mexicano del Seguro Social | 40 | 2025-12-01 | 2025-12-16 |
| Efficacy of Palonosetron Plus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Gynaecological Laparoscopic Surgery Palonosetron and Dexamethason, Palonosetron - Postoperative Nausea and Vomiting | Phase 4 | Completed | Bangladesh Medical University | 76 | 2025-09-10 | 2026-09-10 |
| Dexamethasone to Prevent Side Effects of Spinal Anesthesia in Cesarean Delivery Dexamethasone, Placebo - Hypotension During Cesarean Delivery, Postoperative Nausea and Vomiting (PONV) | Phase 4 | Enrolling by invitation | University Medical Center Ho Chi Minh City (UMC) | 176 | 2025-08-01 | 2026-05-29 |
| Oliceridine on Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery Oliceridine, Sufentanil - Gynecologic Surgical Procedures, Postoperative Nausea and Vomiting (PONV) | Phase 4 | Completed | YanYing Xiao | 96 | 2025-07-21 | 2026-06-09 |
| Ginger to Prevent Nausea and Vomiting After Laparoscopic Cholecystectomy Ginger, Placebo - Postoperative Nausea and Vomiting, Laparoscopic Cholecystectomy | Phase 4 | Recruiting | University Tunis El Manar | 102 | 2025-07-05 | 2026-04-28 |
| Prophylactic Use of Naldemedine on Opioid-induced Nausea and Vomiting in Patients With Cancer: POSEIDON Study Naldemedine, Placebo - Opioid-Induced Nausea and Vomitting(OINV) | Phase 4 | Completed | International University of Health and Welfare | 120 | 2025-06-20 | 2026-06-03 |
| Norepinephrine ED90 Bolus After Spinal Anesthesia in Cesarean Section Norepinephrine - Hypotension, Hypertension | Phase 4 | Completed | Pontificia Universidad Catolica de Chile | 60 | 2025-04-01 | 2025-08-29 |
Showing 20 of 210. Sign in to see all of them.
Postoperative Nausea and Vomiting (142) · Vomiting (67) · Pain, Postoperative (43) · Pain (14) · Postoperative Complications (7) · Pruritus (7) · Agnosia (5) · Constipation (5) · Neoplasms (5) · Abdominal Pain (4) · Osteoarthritis, Knee (4) · Personal Satisfaction (4) · Acute Pain (3) · Fatigue (3)
Pathological Conditions, Signs and Symptoms (210) · Signs and Symptoms (209) · Signs and Symptoms, Digestive (208) · Pathologic Processes (150) · Postoperative Complications (140) · Vomiting (125) · Neurologic Manifestations (71) · Pain (49) · Nervous System Diseases (17) · Behavior (10) · Skin Diseases (10) · Skin and Connective Tissue Diseases (10) · Musculoskeletal Diseases (9) · Neurobehavioral Manifestations (8)
Dexamethasone (53) · Ondansetron (45) · Aprepitant (23) · Sodium Chloride (22) · Saline Solution (20) · Palonosetron (16) · Metoclopramide (13) · Calcium Dobesilate (12) · Propofol (11) · Granisetron (10) · Lidocaine (9) · ramosetron (8) · Bupivacaine (7) · Ketamine (7) · Acetaminophen (6)
Yonsei University (7) · Assiut University (5) · Hvidovre University Hospital (5) · Merck Sharp & Dohme LLC (5) · Pontificia Universidade Catolica de Sao Paulo (4) · Copenhagen University Hospital, Hvidovre (3) · Hospital for Special Surgery, New York (3) · Mayo Clinic (3) · Medical University of Warsaw (3) · Radboud University Medical Center (3) · The Second Affiliated Hospital of Chongqing Medical University (3) · Ankara University (2) · Beth Israel Deaconess Medical Center (2) · Bezmialem Vakif University (2) · Columbia University (2)
United States (58) · South Korea (14) · Brazil (12) · Turkey (Türkiye) (12) · China (11) · Denmark (11) · Egypt (9) · Canada (7) · Italy (4) · Malaysia (4) · Poland (4) · Switzerland (4) · France (3) · India (3) · Indonesia (3)
Nicolai Bang Foss, Dr.med. (3) · David M. Burger, PharmD PhD (2) · Eduardo T Moro, Professor (2) · Gideon Koren, MD (2) · He Huang, MD (2) · Pamela Flood, MD (2) · Shaul Cohen, MD (2) · Abdelrahman Mahmoud, MD (1) · Adam M Thaler, DO (1)
PMID 34002866, PMID 10485781, PMID 21079721, PMID 32467512, PMID 10078396, PMID 10227938, PMID 10433490, PMID 10475299, PMID 10485753, PMID 10598635, PMID 10624646, PMID 10718794, PMID 10730546, PMID 10740539, PMID 10910848, PMID 11028830, PMID 11189177, PMID 11266262, PMID 11273930, PMID 11323159, PMID 11454483, PMID 11474424, PMID 11475180, PMID 11772809, PMID 11812709, PMID 11826129, PMID 12067003, PMID 12358867, PMID 12670812, PMID 12768180, PMID 12818945, PMID 14504060, PMID 14570668, PMID 14574212, PMID 14620731, PMID 14980943, PMID 15064259, PMID 15120791, PMID 15139789, PMID 15189396, PMID 15275765, PMID 1531705, PMID 1535245, PMID 15915040, PMID 16000093, PMID 1609990, PMID 16192766, PMID 16306743, PMID 16464423, PMID 16528908
2017 (2), 2008 (1), 2009 (1), 2019 (1), 2023 (1), UL1RR024150 (1)