22 completed, 13 unknown, 8 recruiting, 2 not yet recruiting. 8 Not applicable, 7 Phase 4, 3 Phase 2, 2 Phase 1, 2 Phase 3.
Follow Myocardial Fibrosis: new trials by email Literature Review of Myocardial Fibrosis trials Research Report on Myocardial Fibrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hormone thERapy Effects on BRAin-HEART Health During the Menopausal Transition Transdermal estradiol, Standard of care - non hormonal - Menopause, Perimenopause | Phase 4 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 100 | 2026-11-01 | 2026-07-29 |
| Neprilysin Inhibition to Reduce Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction Sacubitril-valsartan, Valsartan - Heart Failure With Preserved Ejection Fraction, Myocardial Fibrosis | Phase 4 | Withdrawn | Brigham and Women's Hospital | 2026-08-27 | 2026-08-31 | |
| A Health Coach-Led Digital Lifestyle Intervention (HEALDI) HEALDI Intervention - Myocardial Fibrosis, Left Ventricle Hypertrophy | Not applicable | Not yet recruiting | National University of Singapore | 200 | 2026-04-01 | 2026-04-15 |
| ⁶⁸Ga-FAPI PET/CT for Cardiac Fibrosis in Heart Failure 68Ga-FAPI PET/CT - Myocardial Fibrosis, Heart Failure | Recruiting | University of Coimbra | 30 | 2025-11-17 | 2025-12-29 | |
| High Relaxivity Contrast Agent for Cardiac MR in the Myocardial Scar Assessment Elucirem (Gadopiclenol) - Myocardial Fibrosis | Phase 4 | Recruiting | Johns Hopkins University | 25 | 2025-08-01 | 2026-04-13 |
| Validation of Myocardial Perfusion and Extracellular Volume Assessment Using Photon-Counting Computed Tomography (PCCT) Compared With Cardiac Magnetic Resonance (CMR) in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI) Stress myocardial perfusion imaging with PCCT. Extracellular volume quantification with PCCT. - Myocardial Diseases, Perfusion Imaging | Recruiting | Karolinska University Hospital | 100 | 2025-06-10 | 2026-09-02 | |
| Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF [ARNI + SGLTi + AMR], [SGLTi + previously taken RAAS blocker] - HFpEF, LVDD | Phase 2 | Recruiting | National Medical Research Center for Cardiology, Ministry of Health of Russian Federation | 50 | 2025-03-18 | 2026-04-24 |
| Quantification of Myocardial Fibrosis in Aortic Stenosis High frame rate echocardiography, MRI, Blood test - Aortic Valve Stenosis, Myocardial Fibrosis | Completed | Norwegian University of Science and Technology | 79 | 2025-01-21 | 2026-10-23 | |
| Fibrosis Assessment in Myocardial Infarction-associated Ventricular Aneurysm 18F FAPI-42 PET/CT scan - Acute Myocardial Infarction, Ventricular Aneurysm Following Acute Myocardial Infarction | Recruiting | RenJi Hospital | 20 | 2024-11-01 | 2025-05-29 | |
| SPECT Fibroblast Activation Protein Imaging in Patients With Cardiac Disease 99mTc-FAPI SPECT imaging - Myocardial Fibrosis | Unknown | Henan Institute of Cardiovascular Epidemiology | 50 | 2024-03-01 | 2024-03-22 | |
| Evaluate Aerobic Exercise on Myocardial Fibrosis and Intestinal Flora in Dilated Cardiomyopathy Diagnosed First Time. Cardiac Rehabilitation, Myocardial Fibrosis | Unknown | Nanjing Medical University | 30 | 2023-10-01 | 2023-09-15 | |
| The Effect of Henagliflozin and Metformin on Myocardial Tissue-level Characteristics Henagliflozin, Metformin - Obesity, Type 2 Diabetes | Not applicable | Unknown | RenJi Hospital | 64 | 2023-10-01 | 2023-09-28 |
| Losartan in Prevention of Radiation-Induced Heart Failure Losartan, Radiation Therapy - Breast Cancer, Myocardial Fibrosis | Early Phase 1 | Completed | Massachusetts General Hospital | 5 | 2023-09-13 | 2026-04-06 |
| Ultrahypofractionation and Normal Tissue Toxicity Accelerated Proton Beam Radiation Therapy (PBT), Accelerated Photon Radiation Therapy (XRT) - Breast Cancer, Breast Cancer Female | Not applicable | Active not recruiting | Massachusetts General Hospital | 60 | 2023-08-15 | 2025-11-13 |
| Study of Novel PET Tracer Gallium [68Ga]/ Fluorine [18F] -FAPI-04 in the Diagnosis of Cardiovascular Diseases 68Ga/18F-FAPI-04 - Myocardial Fibrosis | Not applicable | Unknown | Nanjing First Hospital, Nanjing Medical University | 100 | 2023-05-01 | 2023-05-22 |
| Pirfenidone Treat Myocardial Fibrosis After Acute Myocardial Infarction Pirfenidone Oral Capsule, Placebo Oral Capsule - Myocardial Fibrosis | Phase 2 | Unknown | Shanghai Zhongshan Hospital | 100 | 2022-08-05 | 2022-11-10 |
| Liver Disease, Myocardial Fibrosis and Collaterals in the Adult Fontan Patient a Metabolomics and Proteomics Approach Patient Participation, Heart Defects, Congenital | Unknown | Medical University Innsbruck | 300 | 2022-04-01 | 2024-03-13 | |
| Phase IA and IB Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia AAVrh.10hFXN, serotype rh.10 adeno-associated virus (AAV) gene transfer vector expressing the cDNA coding for human FXN, Prednisone - Friedreich Ataxia, Cardiomyopathies | Phase 1 | Recruiting | Weill Medical College of Cornell University | 25 | 2022-02-22 | 2026-09-28 |
| Imaging of Pathologic Fibrosis Using 68Ga-FAP-2286 68Ga-FAP-2286, Positron Emission Tomography (PET) - Liver Fibrosis, Pulmonary Fibrosis | Phase 1 | Completed | Thomas Hope | 16 | 2021-12-09 | 2025-03-21 |
| Modulation of Fibrosis-inducing Pathways in Acute Myocardial Infarction P2Y12 Potent Inhibitor + Aspirin for STEMI patients, Clopidogrel + Aspirin for CCS patients - Myocardial Infarction, Myocardial Fibrosis | Unknown | University of Messina | 50 | 2021-12-01 | 2023-01-25 |
Showing 20 of 49. Sign in to see all of them.
Heart Failure (7) · Aortic Valve Stenosis (6) · Myocardial Infarction (5) · Fibrosis (3) · Hypertrophy, Left Ventricular (3) · Renal Insufficiency, Chronic (3) · Breast Neoplasms (2) · Cardiomyopathies (2) · Diabetes Mellitus, Type 2 (2) · Heart Defects, Congenital (2) · Hypertension (2) · Inflammation (2) · Myocarditis (2) · Univentricular Heart (2) · Ataxia (1)
Cardiovascular Diseases (28) · Heart Diseases (27) · Pathological Conditions, Signs and Symptoms (22) · Pathologic Processes (17) · Vascular Diseases (8) · Aortic Valve Disease (7) · Heart Valve Diseases (7) · Infarction (6) · Ischemia (6) · Necrosis (6) · Ventricular Outflow Obstruction (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Myocardial Ischemia (5) · Pathological Conditions, Anatomical (5) · Cardiomyopathies (4)
Hematologic Tests (3) · Clopidogrel (2) · Echocardiography (2) · Electrocardiography, Ambulatory (2) · Exercise Test (2) · dapagliflozin (2) · 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine (1) · Aspirin (1) · Blood Pressure Monitoring, Ambulatory (1) · Blood Specimen Collection (1) · Echocardiography, Stress (1) · Electrocardiography (1) · Enalapril (1) · Estradiol (1) · Exercise (1)
Massachusetts General Hospital (3) · Norwegian University of Science and Technology (3) · RenJi Hospital (2) · University of Edinburgh (2) · Assistance Publique Hopitaux De Marseille (1) · Azienda Ospedaliero, Universitaria Pisana (1) · Brigham and Women's Hospital (1) · Cardio Med Medical Center (1) · Cell Therapy Ltd. (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dr Manvir Kaur Hayer (1) · Federal University of São Paulo (1) · Henan Institute of Cardiovascular Epidemiology (1) · Hospital Clinic of Barcelona (1) · Imperial College London (1)
United States (16) · China (4) · Norway (4) · United Kingdom (4) · Austria (2) · Italy (2) · Brazil (1) · Denmark (1) · France (1) · Germany (1) · Portugal (1) · Romania (1) · Russia (1) · Singapore (1) · Spain (1)
Rachel Jimenez, MD (2) · Andrew E Arai, M.D. (1) · Calvin WL Chin, MBBS, PhD (1) · Carlos E Rochitte, MD, PhD (1) · Craig Broberg (1) · Elizabeth C Jones, M.D. (1) · Erik Fosse, Professor (1) · Feng Wang (1) · Francisco A Fonseca, MD, PhD (1) · Jennifer H Jordan, PhD (1) · Jing Cui, Ph.D. (1) · Jing Ma (1)
PMID 37676209, PMID 23333188, PMID 27926769, PMID 29258572, PMID 29604289, PMID 31100122, PMID 32541385, PMID 32682713, PMID 32730619, PMID 32861651, PMID 33575428, PMID 34354179, PMID 34587943, PMID 35421939, PMID 36040917, PMID 36064600, PMID 36541642, PMID 36541647, PMID 36584183, PMID 37171121, PMID 37522226, PMID 37664999, PMID 38585865, PMID 38849829, PMID 39772364, PMID 39885199, PMID 40418351, PMID 40558655, PMID 40690085, PMID 40739200, PMID 41073114, PMID 41144431, PMID 41430169, PMID 41629250, PMID 42307907, PMID 42644318
2018 (1), K23HL168163 (1), P01CA261669 (1), R61HL151355 (1)