1025 completed, 200 unknown, 157 recruiting, 122 terminated. 1687 Phase 1, 519 Phase 2.
Follow Musculoskeletal Diseases: new trials by email Literature Review of Musculoskeletal Diseases trials Research Report on Musculoskeletal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care Coaching - Chronic Pain, Musculoskeletal Pain | Phase 1 | Not yet recruiting | VA Office of Research and Development | 30 | 2029-01-01 | 2026-03-06 |
| Cannabichromene Safety in Rheumatoid Arthritis Cannabichromene - Arthritis, Rheumatoid | Phase 1 / Phase 2 | Withdrawn | Crystal Lederhos Smith | 2028-07-15 | 2026-09-23 | |
| Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting Maxillary sinus floor elevation grafting with synthetic bone substitute. - Bone Loss, Osteoclastic, Bone Loss, Alveolar | Phase 1 | Not yet recruiting | Pontificia Universidade Católica do Rio Grande do Sul | 20 | 2027-12-15 | 2026-09-21 |
| Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-07-01 | 2026-11-02 |
| Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-06-01 | 2026-10-30 |
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease TG-C High Dose, TG-C Mid Dose, TG-C Low Dose - Degenerative Disc Disease | Phase 1 | Not yet recruiting | Kolon TissueGene, Inc. | 24 | 2027-01-19 | 2026-08-20 |
| Regenerative Medicine for Joint Hypermobility and Instability Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational) - Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS) | Phase 1 / Phase 2 | Not yet recruiting | Manhattan Pain Medicine, PLLC | 100 | 2027-01-15 | 2026-10-06 |
| Pilot and Feasibility Study of Anti-CD14 for the Treatment of Knee Osteoarthritis Atibuclimab, saline placebo - Knee Osteoarthritis (Knee OA) | Phase 1 | Not yet recruiting | VA Office of Research and Development | 40 | 2027-01-01 | 2026-07-15 |
| Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI) Bone marrow-derived mesenchymal stromal cells (MSCs) - Osteogenesis Imperfecta, Osteogenesis Imperfecta Type III | Phase 1 / Phase 2 | Not yet recruiting | Emory University | 12 | 2027-01-01 | 2026-05-08 |
| SCLife®-LDD hUC-MSCs Injection Therapy for Patients With Lumbar Intervertebral Disc Degeneration human umbilical cord mesenchymal stem cell suspension, total endoscopic extraction of lumbar nucleus pulposus - Lumbar Disc Degeneration | Phase 1 | Suspended | Sclnow Biotechnology Co., Ltd. | 20 | 2026-12-31 | 2026-04-27 |
| The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ONFH) Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), core decompression - Osteonecrosis of Femoral Head | Phase 1 / Phase 2 | Suspended | Sclnow Biotechnology Co., Ltd. | 30 | 2026-12-31 | 2026-04-23 |
| Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients Metformin, Val, Cel and Met XR Low, Val, Cel and Met XR High - Type 2 Diabetes, High Blood Pressure | Phase 1 / Phase 2 | Withdrawn | ARKAY Therapeutics | 2026-12-10 | 2026-07-16 | |
| Calcium Channel Blocker in Myotonic Dystrophy Type 1 Amlodipine - Myotonic Dystrophy 1 | Phase 1 | Not yet recruiting | University of Rochester | 20 | 2026-12-07 | 2025-12-09 |
| Study Investigating the Safety of Anti-CD19 CAR-T Cells Therapy Produced at Gustave Roussy for Adults With Severe and Refractory Systemic Autoimmune Rheumatic Diseases anti-CD19 CAR-T cells - Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE) | Phase 1 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 6 | 2026-12-01 | 2026-09-02 |
| Safety and Tolerability of a Single Intravenous Infusion of BX-U001 in Refractory Rheumatoid Arthritis hUC-MSC suspension, Placebo - Rheumatoid Arthritis | Phase 1 | Not yet recruiting | Baylx Inc. | 16 | 2026-12-01 | 2025-12-23 |
| A Phase 1 Study of QLS2416 Injection in Participants With Autoimmune Diseases QLS2416 Injection - Systemic Lupus Erythematosus, Rheumatoid Arthritis (RA) | Phase 1 | Not yet recruiting | Shanghai Qilu Pharmaceutical Research and Development Center LTD | 76 | 2026-12-01 | 2026-10-30 |
| Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 45 | 2026-11-30 | 2026-11-03 |
| Phase Ia Study of MST-931 in Healthy Adult Subjects MST-931, MST-931 Placebo - Ankylosing Spondylitis (AS) | Phase 1 | Recruiting | Mabsoft Therapeutics (Shanghai) Co., Ltd. | 32 | 2026-11-30 | 2026-11-03 |
| A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune Diseases PF-08154225 - Systemic Lupus Erythematosus, Rheumatoid Arthritis | Phase 1 / Phase 2 | Not yet recruiting | Pfizer | 54 | 2026-11-19 | 2026-10-01 |
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Arthritis, Rheumatoid (384) · Osteoarthritis (175) · Osteoarthritis, Knee (171) · Osteoporosis (113) · Muscular Dystrophy, Duchenne (93) · Lupus Erythematosus, Systemic (66) · Gout (56) · Arthritis (54) · Myositis (45) · Sjogren's Syndrome (45) · Scleroderma, Systemic (42) · Pain (41) · Autoimmune Diseases (39) · Bone Neoplasms (39)
Joint Diseases (894) · Rheumatic Diseases (811) · Arthritis (797) · Skin and Connective Tissue Diseases (571) · Connective Tissue Diseases (520) · Immune System Diseases (500) · Autoimmune Diseases (451) · Bone Diseases (440) · Nervous System Diseases (388) · Muscular Diseases (368) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (325) · Pathological Conditions, Signs and Symptoms (296) · Neuromuscular Diseases (290) · Genetic Diseases, Inborn (275)
Methotrexate (28) · Cyclophosphamide (21) · Rituximab (18) · Sodium Chloride (18) · Saline Solution (17) · fludarabine (15) · tocilizumab (15) · Naproxen (14) · Abatacept (13) · Hyaluronic Acid (12) · Denosumab (11) · Human Growth Hormone (11) · Injections (11) · sarilumab (11) · Midazolam (10)
GlaxoSmithKline (31) · Pfizer (29) · Bristol-Myers Squibb (26) · AstraZeneca (24) · Amgen (23) · Sarepta Therapeutics, Inc. (18) · Eli Lilly and Company (16) · Jiangsu HengRui Medicine Co., Ltd. (16) · Sanofi (16) · Novartis Pharmaceuticals (15) · Novo Nordisk A/S (14) · Merck Sharp & Dohme LLC (13) · Mayo Clinic (12) · Hoffmann-La Roche (10) · National Taiwan University Hospital (10)
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Hamid Gourabi, PhD (8) · Nasser Aghdami, MD,PhD (8)
PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 21518322, PMID 25769789, PMID 26058927, PMID 31401903, PMID 37539981, PMID 15100156, PMID 16711659, PMID 17284531, PMID 20175977, PMID 20214807, PMID 21148044, PMID 23013236, PMID 23607606, PMID 25749867, PMID 25822648, PMID 25919461, PMID 28143815, PMID 29671202, PMID 29776017, PMID 31442616, PMID 32453485, PMID 32816215, PMID 33127856, PMID 33229973, PMID 33506875, PMID 33754315, PMID 34870800, PMID 35022448, PMID 36526796, PMID 36600185, PMID 36601090, PMID 36931693, PMID 38258274, PMID 38753764, PMID 39284030, PMID 39454617, PMID 40152935, PMID 40576086, PMID 40826764, PMID 41491634, PMID 41607103, PMID 10037543, PMID 10360702, PMID 10415784, PMID 10488513
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