1775 completed, 356 unknown, 342 terminated, 217 recruiting. 3040 Phase 2, 517 Phase 1, 357 Phase 3.
Follow Musculoskeletal Diseases: new trials by email Literature Review of Musculoskeletal Diseases trials Research Report on Musculoskeletal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cannabichromene Safety in Rheumatoid Arthritis Cannabichromene - Arthritis, Rheumatoid | Phase 1 / Phase 2 | Withdrawn | Crystal Lederhos Smith | 2028-07-15 | 2026-09-23 | |
| Neoadjuvant Pimicotinib Combined With Surgery Versus Upfront Surgery for Diffuse Tenosynovial Giant Cell Tumor Pimicotinib, Tumor resection surgery - Tenosynovial Giant Cell Tumor, Diffuse | Phase 2 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 84 | 2027-10-01 | 2026-07-16 |
| A Study to Determine the Safety and Efficacy of TG-C in Subjects With Symptomatic Early Hip Osteoarthritis TG-C, Placebo Control - Degenerative Osteoarthritis | Phase 2 | Not yet recruiting | Kolon TissueGene, Inc. | 255 | 2027-10-01 | 2026-08-20 |
| Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial testosterone cypionate, finasteride, placebo injection - Spinal Cord Injury, Spinal Cord Injuries | Phase 2 / Phase 3 | Not yet recruiting | VA Office of Research and Development | 300 | 2027-10-01 | 2026-08-04 |
| Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis | Phase 2 / Phase 3 | Not yet recruiting | Genascence Corporation | 240 | 2027-07-01 | 2026-09-21 |
| Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-07-01 | 2026-08-26 |
| Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-06-01 | 2026-08-26 |
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE) Exercise, Duloxetine, Placebo - Knee Osteoarthritis, Pain | Phase 2 | Not yet recruiting | VA Office of Research and Development | 102 | 2027-03-01 | 2026-06-16 |
| Regenerative Medicine for Joint Hypermobility and Instability Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational) - Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS) | Phase 1 / Phase 2 | Not yet recruiting | Manhattan Pain Medicine, PLLC | 100 | 2027-01-15 | 2026-10-06 |
| Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI) Bone marrow-derived mesenchymal stromal cells (MSCs) - Osteogenesis Imperfecta, Osteogenesis Imperfecta Type III | Phase 1 / Phase 2 | Not yet recruiting | Emory University | 12 | 2027-01-01 | 2026-05-08 |
| A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders Nabiximols, Placebo - NMO Spectrum Disorder, Spasticity, Muscle | Phase 2 | Withdrawn | Michael, Levy M.D.,Ph.D. | 2026-12-31 | 2025-07-16 | |
| The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ONFH) Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), core decompression - Osteonecrosis of Femoral Head | Phase 1 / Phase 2 | Suspended | Sclnow Biotechnology Co., Ltd. | 30 | 2026-12-31 | 2026-04-23 |
| A Study of SAT-3247 to Evaluate the Safety, Tolerability, and Efficacy in Participants With Facioscapulohumeral Muscular Dystrophy (FSHD) forazapadin, Placebo Comparator - Facioscapulohumeral Muscular Dystrophy (FSHD) | Phase 2 | Not yet recruiting | Satellos Bioscience, Inc. | 51 | 2026-12-15 | 2026-10-13 |
| Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients Metformin, Val, Cel and Met XR Low, Val, Cel and Met XR High - Type 2 Diabetes, High Blood Pressure | Phase 1 / Phase 2 | Withdrawn | ARKAY Therapeutics | 2026-12-10 | 2026-07-16 | |
| Platform Study of Targeted Therapies for Adults With Moderately to Severely Active Rheumatoid Arthritis ABBV-722, Upadacitinib - Rheumatoid Arthritis | Phase 2 | Not yet recruiting | AbbVie | 250 | 2026-12-07 | 2026-10-29 |
| Safety and Efficacy of Topical Infliximab in Autoimmune Dry Eye Disease Infliximab 0.1%, Loteprednol - Sjogren Syndrome, Sjogren Syndrome With Keratoconjunctivitis | Phase 2 | Not yet recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 38 | 2026-12-01 | 2026-06-26 |
| CD19-B Cell Depletion in PAIS-ME/CFS Patients Inebilizumab, Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID 19 Condition (PCC or Long COVID) | Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 38 | 2026-12-01 | 2026-07-24 |
| Phase 2 Trial of FT2109 for the Treatment of Psoriatic Arthritis FT2109 Dosing Regimen 1, FT2109 Dosing Regimen 2, Matching Placebo - Psoriatic Arthritis (PsA) | Phase 2 | Not yet recruiting | Forward Therapeutics | 210 | 2026-12-01 | 2026-10-09 |
| Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC), Placebo - Sjogren Syndrome, Xerostomia | Phase 2 | Not yet recruiting | Banu Erkal | 30 | 2026-12-01 | 2026-09-24 |
Showing 20 of 3040. Sign in to see all of them.
Arthritis, Rheumatoid (567) · Osteoarthritis, Knee (349) · Osteoarthritis (347) · Osteoporosis (164) · Muscular Dystrophy, Duchenne (139) · Pain (137) · Arthritis (126) · Fibromyalgia (109) · Sjogren's Syndrome (77) · Gout (71) · Bone Diseases, Metabolic (67) · Arthritis, Psoriatic (64) · Dermatomyositis (61) · Spondylitis, Ankylosing (57)
Joint Diseases (1586) · Rheumatic Diseases (1404) · Arthritis (1339) · Skin and Connective Tissue Diseases (911) · Connective Tissue Diseases (799) · Bone Diseases (769) · Immune System Diseases (728) · Nervous System Diseases (728) · Muscular Diseases (708) · Pathological Conditions, Signs and Symptoms (682) · Autoimmune Diseases (671) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (522) · Neuromuscular Diseases (506) · Genetic Diseases, Inborn (452)
Methotrexate (89) · Sodium Chloride (64) · Saline Solution (49) · Adalimumab (37) · Alendronate (31) · Hyaluronic Acid (31) · Rituximab (31) · Denosumab (28) · Teriparatide (28) · Zoledronic Acid (28) · tofacitinib (28) · Cholecalciferol (26) · Botulinum Toxins, Type A (24) · Human Growth Hormone (22) · Abatacept (21)
Novartis Pharmaceuticals (59) · Pfizer (54) · Amgen (36) · Eli Lilly and Company (31) · GlaxoSmithKline (28) · AbbVie (23) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (22) · Hoffmann-La Roche (20) · Merck Sharp & Dohme LLC (19) · Charite University, Berlin, Germany (18) · Assistance Publique - Hôpitaux de Paris (17) · AstraZeneca (17) · Bristol-Myers Squibb (17) · National Center for Complementary and Integrative Health (NCCIH) (16) · Sanofi (16)
United States (1454) · Germany (299) · Canada (298) · Poland (291) · United Kingdom (288) · Spain (269) · France (219) · Italy (192) · Australia (176) · Czechia (175) · China (170) · Hungary (163) · Belgium (154) · Netherlands (144) · Russia (125)
PMID 32816215, PMID 33127856, PMID 34870800, PMID 36526796, PMID 36600185, PMID 36601090, PMID 36931693, PMID 39192350, PMID 25047021, PMID 28143815, PMID 38958913, PMID 26275429, PMID 28941219, PMID 40194794, PMID 41807031, PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 25769789, PMID 26529632, PMID 29463520, PMID 30842122, PMID 31401903, PMID 32417537, PMID 32762706, PMID 32956407, PMID 34041702, PMID 34706874, PMID 36205910, PMID 37453736, PMID 37747626, PMID 38649657, PMID 42613652, PMID 12795371, PMID 16911575, PMID 17284531, PMID 19404957, PMID 23254770, PMID 24476416, PMID 24699939, PMID 25035839, PMID 25919461, PMID 25925602, PMID 26112278, PMID 26132314, PMID 26573217, PMID 27156561, PMID 27338778
2016 (34), 2015 (28), 2019 (27), 2014 (25), 2009 (24), 2023 (24), 2025 (19), 2017 (18), 2018 (16), 2008 (11), 2004 (7), 2005 (4), K12HD043494 (3), P50AT000090 (3), R01AI047040 (3)