8 completed, 2 unknown, 1 withdrawn. 11 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Completed 8, Unknown 2, Withdrawn 1 |
| Phase 2 | 3 | Completed 2, Unknown 1 |
Follow Muscle Weakness: new trials by email Literature Review of Muscle Weakness trials Research Report on Muscle Weakness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Telitacicept in Generalized Myasthenia Gravis Telitacicept, Placebo - Myasthenia Gravis, Generalized | Phase 3 | Completed | RemeGen Co., Ltd. | 114 | 2023-03-28 | 2025-05-23 |
| A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) MT1621 - Thymidine Kinase 2 Deficiency | Phase 3 | Withdrawn | Zogenix MDS, Inc. | 2022-09-30 | 2023-09-01 | |
| Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD) Elamipretide, Placebo - Mitochondrial Myopathies, Mitochondrial Pathology | Phase 3 | Completed | Stealth BioTherapeutics Inc. | 102 | 2022-04-29 | 2025-10-24 |
| Does Gabapentin Reduce Quadriceps Muscle Weakness After Anterior Cruciate Ligament Reconstruction? Gabapentin, Tramadol, Panadol - Muscle Weakness, Anterior Cruciate Ligament Rupture | Phase 2 / Phase 3 | Unknown | Hospital Authority, Hong Kong | 30 | 2018-07-01 | 2018-04-12 |
| Effect of PROGRESSive Training and Teststerone in Older Frail Men testosterone, Progressive muscle training - Muscle Weakness | Phase 2 / Phase 3 | Completed | University Hospital, Gentofte, Copenhagen | 192 | 2016-11-01 | 2024-05-29 |
| Effects of Creatine Supplementation on Muscle Mass and Function Among Older Women Subjected to Resistance Training Resistance exercise training, Creatine - Muscle Weakness | Phase 3 | Completed | University of Chile | 50 | 2014-10-01 | 2015-10-30 |
| Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex sugammadex 2mg/kg, neostigmine, sugammadex 4mg/kg - Diaphragmatic Dysfunction, Muscle Weakness | Phase 3 | Completed | University Hospital, Antwerp | 75 | 2013-10-01 | 2018-10-24 |
| The Effect of Alfacalcidol on Muscle Strength in Elderly Indonesian Women : A Randomized Controlled Trial alfacalcidol - Muscle Weakness | Phase 3 | Completed | Universitas Indonesia | 122 | 2012-04-01 | 2014-12-30 |
| Sedation Optimisation Strategy (S.O.S.) Ventilation Therapy strategy - Surgery, Critical Illness | Phase 3 | Completed | University Hospital, Montpellier | 140 | 2011-12-01 | 2015-12-02 |
| Efficacy and Tolerance of Early Launching of Nocturnal Non Invasive Bilevel pressure ventilator - Myopathy, Muscular Weakness | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 77 | 2010-10-01 | 2017-11-20 |
| Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms Coenzyme Q10, Placebo - Pain, Weakness | Phase 2 / Phase 3 | Completed | Catherine Buettner | 68 | 2009-12-01 | 2017-01-23 |
Mitochondrial Diseases (2) · Pain (2) · Agnosia (1) · Anterior Cruciate Ligament Injuries (1) · Anxiety Disorders (1) · Asthenia (1) · Autoimmune Diseases (1) · Critical Illness (1) · Delirium (1) · Depression (1) · Mental Disorders (1) · Mitochondrial Myopathies (1) · Mitochondrial complex I deficiency (1) · Motor Activity (1)
Musculoskeletal Diseases (11) · Neurologic Manifestations (11) · Neuromuscular Manifestations (11) · Pathologic Processes (11) · Pathological Conditions, Signs and Symptoms (11) · Signs and Symptoms (11) · Muscular Diseases (10) · Nervous System Diseases (10) · Neuromuscular Diseases (4) · Atrophy (2) · Behavior (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Disease Attributes (2) · Genetic Diseases, Inborn (2) · Metabolic Diseases (2)
Acetaminophen (1) · Autogenic Training (1) · Creatine (1) · Deoxycytidine (1) · Gabapentin (1) · Neostigmine (1) · Resistance Training (1) · Sugammadex (1) · Testosterone (1) · Thymidine (1) · Tramadol (1) · alfacalcidol (1) · arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide (1) · coenzyme Q10 (1) · telitacicept (1)
Assistance Publique - Hôpitaux de Paris (1) · Catherine Buettner (1) · Hospital Authority, Hong Kong (1) · RemeGen Co., Ltd. (1) · Stealth BioTherapeutics Inc. (1) · Universitas Indonesia (1) · University Hospital, Antwerp (1) · University Hospital, Gentofte, Copenhagen (1) · University Hospital, Montpellier (1) · University of Chile (1) · Zogenix MDS, Inc. (1)
France (2) · United States (2) · Australia (1) · Belgium (1) · Chile (1) · China (1) · Denmark (1) · Germany (1) · Hungary (1) · Indonesia (1) · Italy (1) · Netherlands (1) · New Zealand (1) · Norway (1) · Spain (1)
Catherine Buettner, MD, MPH (1) · Gerald GC Chanques, MD, PhD (1) · Iin Anugrahini (1) · Karsten Overgaard, M.D. (1) · Sandra Hirsch, MD (1)
PMID 28935558, PMID 29500160, PMID 31629404, PMID 39289825
K23AR055664 (1)