21 completed, 4 unknown, 3 terminated, 2 recruiting. 13 Phase 4, 10 Not applicable, 4 Phase 3, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 13 | Completed 10, Terminated 2, Withdrawn 1 |
| Not applicable | 10 | Completed 5, Unknown 3, Recruiting 2 |
| Phase 3 | 4 | Completed 3, Terminated 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Morphine Versus Dexmedetomidine as Adjuvants to Bupivacaine in TAP Block in Lower Abdominal Surgeries Transversus abdominis plane block + Dexmedetomidine, Morphine - Morphine, Dexmedetomidine | Not applicable | Completed | Cairo University | 70 | 2025-12-01 | 2026-09-25 |
| Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial Oliceridine, Morphine, Sufentanil - Sufentanil, Morphine | Not applicable | Recruiting | Anqing Municipal Hospital | 90 | 2025-06-01 | 2026-06-01 |
| Effect of Oliceridine Analgesia on Postoperative Nause and Vomiting Oliceridine, Morphine - Laparoscopic Colorectal Surgery, Postoperative Analgesia | Phase 4 | Completed | Peking University First Hospital | 252 | 2024-07-02 | 2026-06-24 |
| Intraoperative Administration of Intravenous Morphine in Patients Undergoing Laparoscopic Cholecystectomy Intraoperative morphine - Postoperative Pain, Morphine | Unknown | Esbjerg Hospital - University Hospital of Southern Denmark | 300 | 2024-06-01 | 2024-08-28 | |
| Determining the Optimal Dose of Intrathecal Morphine for Post-Cesarean Analgesia Intrathecal morphine - Morphine, Cesarean Section | Not applicable | Recruiting | University of Ioannina | 100 | 2023-07-04 | 2026-05-07 |
| Dexmedetomidine and Morphine as Adjuvants to US Guided Erector Spinae Plane Blocks in Elective Thoracic Surgeries erector spinae plane block with a combination of ropivacaine and morphine, erector spinae plane block with a combination of ropivacaine and dexmedetomidine, erector spinae plane block with ropivacaine only - Pain, Postoperative, Pain, Acute | Not applicable | Unknown | Dr Kassiani Theodoraki | 90 | 2023-05-01 | 2023-05-06 |
| Morphine and Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound-guided Erector Spinae Plane Block for Open Subcostal Renal Surgeries Morphine, Dexmedetomidine, Erector spinae plane block - Morphine, Dexmedetomidine | Not applicable | Completed | Kafrelsheikh University | 147 | 2023-05-01 | 2025-06-10 |
| Observational Retrospective Study on Spinal Analgesia in Laparoscopic and Laparotomic Hysterectomy Administration of morphine by intrathecal route, Administration of morphine by intravenous route - Pain, Postoperative, Hysterectomy | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 670 | 2023-03-13 | 2026-02-12 | |
| Dexmedetomidine Plus Low Dose Morphine Versus Standard Dose of Morphine in PCA in Children . standard dose morphine, low dose morphine plus dexmedetomidine - PCA, Children | Not applicable | Unknown | Beni-Suef University | 60 | 2023-02-01 | 2024-09-25 |
| Prophylactic Mirtazapine and Different Doses of Intrathecal Morphine in Preventing Nausea and Vomiting After Cesarean Section Mirtazapine + Bupivacaine + Morphine, Placebo + Bupivacaine + Morphine, Placebo+ Bupivacaine + Morphine - Prophylactic, Mirtazapine | Not applicable | Completed | Kafrelsheikh University | 120 | 2023-01-01 | 2024-11-08 |
| Rescue Quadratus Lumborum Blocks for Post-cesarean Pain Saline, Bupivacaine, Dexamethasone - Morphine, Analgesics | Phase 4 | Withdrawn | The University of Texas Health Science Center, Houston | 2022-01-01 | 2023-11-03 | |
| Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine Morphine - Morphine, Histamine | Not applicable | Completed | Aalborg University | 26 | 2021-07-01 | 2023-01-18 |
| Morphine Versus Ketamine as Adjuvants in Paravertebral Blocks local anesthetic-morphine, local anesthetic-ketamine, local anesthetic - Pain, Postoperative, Pain, Acute | Not applicable | Unknown | Aretaieion University Hospital | 90 | 2021-04-16 | 2023-05-06 |
| Side Effects of a Single Shot Intrathecal Morphine in Clinical Practice, a Retrospective Analysis Intrathecal Morphine - Morphine, Morphine Adverse Reaction | Active not recruiting | Universitaire Ziekenhuizen KU Leuven | 600 | 2021-03-01 | 2026-05-05 | |
| Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine 2% lidocaine with 1:200,000 epinephrine and epidural morphine, 3% 2-chloroprocaine and epidural morphine - Physiological Effect of Drugs, Morphine | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 44 | 2020-05-11 | 2022-05-26 |
| A Relation of Morphine-induced Itch and Pain Processing Morphine, Placebo oral tablet, Histamine - Morphine, Itch | Not applicable | Completed | Aalborg University | 24 | 2020-01-15 | 2020-07-08 |
| Slow-Release Oral Morphine for the Treatment of Opioid Use Disorder Slow release oral morphine (SROM), Methadone - Opioid-Related Disorders, Opiate Substitution Treatment | Phase 3 | Terminated | M. Eugenia Socias | 27 | 2019-12-06 | 2022-02-10 |
| Erectus Nerve Block for Lumbar Spine Surgery Local administration of ropivacaine, Local administration of placebo (saline solution) - Spine Surgery, Pain Relief | Phase 3 | Completed | Centre Hospitalier Universitaire de Nīmes | 50 | 2019-11-27 | 2025-12-04 |
| MORphine Use in the Fascia Iliaca Compartment Block With UltraSound Levobupivacaine, Placebo, Acetaminophen - Humans, Anesthetics, Local | Phase 4 | Terminated | Zuyderland Medisch Centrum | 55 | 2019-01-28 | 2021-05-06 |
| Genetic Variation in Organic Cation Transport 1 (OCT1) and Its Significance for Morphine Pharmacokinetics Morphine - Organic Cation Transporter 1, Morphine | Phase 1 | Completed | University of Southern Denmark | 86 | 2018-06-01 | 2020-06-29 |
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Pain, Postoperative (8) · Agnosia (5) · Acute Pain (3) · Chronic Pain (2) · Emergencies (2) · Postoperative Nausea and Vomiting (2) · Dyspnea (1) · Femoral Fractures (1) · Hip Fractures (1) · Lung Diseases, Interstitial (1) · Nausea (1) · Neuralgia (1) · Obesity (1) · Opioid-Related Disorders (1) · Pain (1)
Pathological Conditions, Signs and Symptoms (18) · Signs and Symptoms (17) · Pathologic Processes (13) · Neurologic Manifestations (12) · Postoperative Complications (10) · Pain (9) · Nervous System Diseases (5) · Neurobehavioral Manifestations (5) · Perceptual Disorders (5) · Signs and Symptoms, Digestive (3) · Disease Attributes (2) · Nausea (2) · Vomiting (2) · Behavior (1) · Body Weight (1)
Morphine (16) · Dexmedetomidine (4) · Sodium Chloride (4) · Sufentanil (4) · Bupivacaine (3) · ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine (2) · Analgesia, Patient-Controlled (2) · Lidocaine (2) · Saline Solution (2) · Acetaminophen (1) · Alfentanil (1) · Analgesia, Epidural (1) · Anesthetics, Local (1) · Atracurium (1) · Dexamethasone (1)
Aalborg University (2) · Kafrelsheikh University (2) · The University of Texas Health Science Center, Houston (2) · Anqing Municipal Hospital (1) · Aretaieion University Hospital (1) · Beni-Suef University (1) · Cairo University (1) · Centre Hospitalier Universitaire de Nīmes (1) · Charles University, Czech Republic (1) · Dr Kassiani Theodoraki (1) · Esbjerg Hospital - University Hospital of Southern Denmark (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · KK Women's and Children's Hospital (1) · Karolinska University Hospital (1) · M. Eugenia Socias (1)
Denmark (5) · Egypt (4) · France (3) · Greece (3) · Netherlands (3) · Canada (2) · China (2) · Malaysia (2) · United States (2) · Belgium (1) · Czechia (1) · Italy (1) · Singapore (1) · Sweden (1) · Thailand (1)
Kassiani Theodoraki, PhD, DESA (2) · Linden Lee, MD (2) · Aart Jan W Teunissen, MD (1) · Chian Yong Liu, MMed (Anaes) (1) · Danny F Hoogma, MD, PhD (1) · Dong-Xin Wang, PHD (1) · Farida Ithnin, MBBCh (1) · Geoffrey Avis, Md (1) · Jiri Malek, M.D. (1) · Loghman Henareh, MD; PhD (1) · M. Eugenia Socias, MD, MSc (1) · Mark V Koning, MD, DESA (1) · Nawzad Saleh, MD, PhD (1)
PMID 1015603, PMID 10740539, PMID 11331167, PMID 11331334, PMID 11374619, PMID 11472277, PMID 12411815, PMID 12548273, PMID 12560416, PMID 14622770, PMID 16846542, PMID 17138203, PMID 17413915, PMID 18686750, PMID 18762870, PMID 19157368, PMID 19174373, PMID 19690943, PMID 22506940, PMID 23300227, PMID 23569691, PMID 23788067, PMID 23878064, PMID 24157979, PMID 25304008, PMID 2589650, PMID 26330019, PMID 26759680, PMID 27714758, PMID 27787895, PMID 28420629, PMID 28510797, PMID 30426190, PMID 30636504, PMID 30881102, PMID 30975187, PMID 31162798, PMID 31388805, PMID 31567573, PMID 31845316, PMID 32467512, PMID 32703194, PMID 33025536, PMID 33210266, PMID 33238043, PMID 34351590, PMID 35863786, PMID 36534717, PMID 36909334, PMID 37556070
2015 (1), 2016 (1), 2019 (1)