256 completed, 85 unknown, 25 terminated, 21 recruiting. 232 Not applicable, 30 Phase 4, 19 Phase 2, 19 Phase 3, 13 Phase 1.
Follow this condition Literature Review of Morbid Obesity trials Research Report on Morbid Obesity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tapered Versus Abrupt Discontinuation of Semaglutide After Treatment of Recurrent Weight Gain or Suboptimal Response Following Metabolic and Bariatric Surgery Semaglutide weekly injection, Placebo - Morbid Obesity | Phase 4 | Not yet recruiting | General Committee of Teaching Hospitals and Institutes, Egypt | 100 | 2026-10-01 | 2026-10-05 |
| Semaglutide Given Before and After Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass for Recurrent Weight Gain Semaglutide weekly injection, Placebo - Morbid Obesity | Phase 4 | Not yet recruiting | General Committee of Teaching Hospitals and Institutes, Egypt | 100 | 2026-10-01 | 2026-10-05 |
| Semaglutide Before Primary Metabolic and Bariatric Surgery in Patients With BMI 60 kg/m² or Higher Semaglutide weekly injection, Placebo - Morbid Obesity | Phase 4 | Not yet recruiting | General Committee of Teaching Hospitals and Institutes, Egypt | 100 | 2026-10-01 | 2026-10-05 |
| Semaglutide 2.4 mg Once Weekly for Recurrent Weight Gain After Metabolic and Bariatric Surgery (RESURGE) Semaglutide weekly injection, Placabo - Morbid Obesity | Phase 4 | Not yet recruiting | General Committee of Teaching Hospitals and Institutes, Egypt | 104 | 2026-10-01 | 2026-10-05 |
| Immediate Versus Criterion-triggered Semaglutide for Suboptimal Clinical Response One Year After Primary Metabolic and Bariatric Surgery Semaglutide weekly injection, Placebo - Morbid Obesity | Phase 4 | Not yet recruiting | General Committee of Teaching Hospitals and Institutes, Egypt | 100 | 2026-10-01 | 2026-10-05 |
| Pilot Study on the Effectiveness and Safety of OPTILENE® SILVER MESH ELASTIC in Prevention of Surgical Site Infection (SSI) and Incisional Hernia (IH) Prophylactic mesh - Abdominal Aortic Aneurysm, Morbid Obesity | Not yet recruiting | Aesculap AG | 110 | 2026-09-01 | 2026-06-02 | |
| GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity GLP-1 receptor agonist therapy - Morbid Obesity, Anorectal Diseases | Not yet recruiting | Gazi University | 100 | 2026-08-01 | 2026-06-25 | |
| Impact of Bariatric Surgery on Female Sexual Function and Sex Hormones Sleeve Gastrectomy, Gastric Bypass - Morbid Obesity | Recruiting | Cairo University | 40 | 2026-06-05 | 2026-06-10 | |
| Investigation of the Effects of Whole Body Vibration Application on Muscle Functional Level, Physical Fitness and Respiratory Parameters After Bariatric Surgery Resistance Training, Whole Body Vibration, Control Group - Obesity & Overweight, Morbid Obesity | Not applicable | Not yet recruiting | Kirsehir Ahi Evran Universitesi | 60 | 2026-05-30 | 2026-05-22 |
| Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients Morbid Obesity, Obesity | Not yet recruiting | Assiut University | 45 | 2026-05-01 | 2026-04-21 | |
| Interaction Between Head/Neck Position and C-MAC Blade Geometry on Videolaryngoscopic Intubation in Morbidly Obese Patients: A Randomized Controlled Trial Sniffing position and using MAC blade., Ramped position and MAC Blade, videolaryngoscopy - Morbid Obesity | Not applicable | Active not recruiting | Ain Shams University | 140 | 2026-04-17 | 2026-06-09 |
| Stool Analysis After Sleeve Gastrectomy vs Gastric Bypass Laparoscopic Sleeve Gastrectomy, Mini Gastric Bypass, Roux-en-Y Gastric Bypass - Morbid Obesity | Recruiting | Cairo University | 50 | 2026-04-05 | 2026-05-18 | |
| Cost-Effectiveness and Outcome of Robot-assisted Vs Laparoscopic Roux-en-Y Gastric Bypass Laparoscopic and robotic (DaVinci) RYGB - Morbid Obesity | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 512 | 2026-01-01 | 2025-09-04 |
| Impact of Reverse Trendelenburg on ONSD in Obesity Surgery Pre-pneumoperitoneum Reverse Trendelenburg Group - Morbid Obesity | Not applicable | Completed | Bagcilar Training and Research Hospital | 90 | 2026-01-01 | 2026-07-14 |
| Chrono-ALIGN: A Chronotype-Based Chrono-Nutrition Intervention in Post-Bariatric Patients Standard Post-Bariatric Care (Control), Early Time-Restricted Eating (eTRE), Chronotype-Based Chrono-Nutrition (CB-CN) - Obesity (Disorder), Morbid Obesity | Not applicable | Not yet recruiting | King Saud University | 246 | 2026-01-01 | 2026-01-07 |
| Ketodex Versus Opioid Based Anesthesia in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy. ketamine and dexmeditomidine combination, Fentanyl (IV) - Morbid Obesity | Not applicable | Active not recruiting | Cairo University | 8 | 2025-11-11 | 2026-04-08 |
| Effect of Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass on Gastroesophageal Reflux Disease: An 8-Year Prospective Cohort Study Gastroesophageal Reflux Disease, Morbid Obesity | Enrolling by invitation | Clinica Gastrobese | 75 | 2025-09-17 | 2025-09-25 | |
| EOIB for Laparoscopic Sleeve Gastrectomy Bilateral ultrasound guided external oblique intercostal block (EOIB), ıv morphine PCA - Acute Pain, Regional Anesthesia | Completed | Ondokuz Mayıs University | 20 | 2025-08-01 | 2025-12-23 | |
| The Effect of Cognitive Function Level in Morbidly Obese Patients Obesity, Morbid Obesity | Not yet recruiting | Kocaeli City Hospital | 77 | 2025-07-22 | 2025-06-29 | |
| Efficacy of Nebulized Dexmedetomidine on Blunting Hemodynamic Changes During Intubation and Pneumoperitoneum in Morbid Obese Patients During Laparoscopic Bariatric Surgery Dexmedetomidine, Normal Saline - Nebulization, Dexmedetomidine | Not applicable | Completed | Tanta University | 90 | 2025-07-10 | 2025-12-23 |
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Obesity, Morbid (432) · Obesity (104) · Weight Loss (39) · Metabolic Syndrome (21) · Diabetes Mellitus (16) · Motor Activity (13) · Insulin Resistance (12) · Non-alcoholic Fatty Liver Disease (11) · Gastroesophageal Reflux (10) · Hypertension (10) · Diabetes Mellitus, Type 2 (9) · Postoperative Complications (8) · Fatty Liver (6) · Pain, Postoperative (6) · Sleep Apnea, Obstructive (6)
Nutrition Disorders (432) · Nutritional and Metabolic Diseases (432) · Overnutrition (432) · Pathological Conditions, Signs and Symptoms (432) · Signs and Symptoms (432) · Body Weight (430) · Overweight (429) · Obesity (328) · Glucose Metabolism Disorders (50) · Metabolic Diseases (50) · Body Weight Changes (44) · Digestive System Diseases (39) · Pathologic Processes (39) · Hyperinsulinism (29) · Endocrine System Diseases (27)
Gastric Bypass (27) · Bariatric Surgery (26) · Exercise (6) · Ketamine (5) · Acetaminophen (4) · Fentanyl (4) · Saline Solution (4) · Bupivacaine (3) · Caloric Restriction (3) · Dexmedetomidine (3) · Diet (3) · Lidocaine (3) · Propofol (3) · Rocuronium (3) · Sugammadex (3)
Mansoura University (13) · Rijnstate Hospital (10) · IHU Strasbourg (9) · Assistance Publique - Hôpitaux de Paris (6) · General Committee of Teaching Hospitals and Institutes, Egypt (6) · Inonu University (6) · Istanbul University (6) · Minia University (6) · Ain Shams University (5) · Ethicon Endo-Surgery (5) · Hospital Universitari de Bellvitge (5) · University of Alberta (5) · University of Patras (5) · Cairo University (4) · Catholic University of the Sacred Heart (4)
United States (109) · Egypt (43) · France (33) · Spain (23) · Turkey (Türkiye) (23) · Italy (21) · Netherlands (21) · Canada (15) · Israel (15) · Brazil (14) · Norway (10) · Greece (9) · Germany (8) · Chile (6) · United Kingdom (6)
John P Cello, MD (4) · Andrei Keidar, MD (3) · Sameh H Emile, M.D. (3) · Alaa M Sewefy, MD (2) · Alexandros Kokkinos, MD, PhD (2) · F.J. Berends, MD, PhD (2) · Geltrude Mingrone, MD (2) · Gerhard Prager, M.D. (2) · Jonathan T Carter, MD (2) · Michel Vix, MD (2) · Michele Carron, MD (2) · Miguel J Garcia-Oria, MD PhD FACS (2) · Ninh T Nguyen, MD (2) · Santiago Horgan, MD (2)
PMID 20010088, PMID 22963820, PMID 24527718, PMID 30247434, PMID 37652841, PMID 38055284, PMID 39819027, PMID 40854969, PMID 41077621, PMID 10592173, PMID 10604470, PMID 11435250, PMID 11472277, PMID 11549535, PMID 11687509, PMID 11733397, PMID 11867408, PMID 12194550, PMID 12456460, PMID 12540590, PMID 14674978, PMID 14750005, PMID 15105237, PMID 15502875, PMID 15864338, PMID 15946441, PMID 15978146, PMID 16076986, PMID 16235331, PMID 16259892, PMID 16271160, PMID 16778582, PMID 17128540, PMID 17253531, PMID 17360978, PMID 17728530, PMID 17885457, PMID 17894144, PMID 18040751, PMID 18193178, PMID 18308313, PMID 18387434, PMID 19403595, PMID 19587363, PMID 19638921, PMID 19641201, PMID 19689793, PMID 19730234, PMID 19926983, PMID 20124732
2009 (2), 2014 (1), R01DK067561 (1), R01DK072526 (1), R01DK107629 (1), R01DK126721 (1), R21DK129893 (1), U01DK066557 (1)