559 completed. 559 Phase 3, 61 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 559 | Completed 559 |
| Phase 2 | 61 | Completed 61 |
Follow Mood Disorders: new trials by email Literature Review of Mood Disorders trials Research Report on Mood Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Safety and Efficacy of Oral LPCN 1154A in Women With Severe PPD LPCN 1154A, Placebo - Depression, Postpartum, Depression, Post-Partum | Phase 3 | Completed | Lipocine Inc. | 90 | 2025-06-16 | 2026-02-24 |
| The Research of Ammoxetine Hydrochloride Enteric-coated Tablets in Subjects With Depression Ammoxetine, Placebo, Sertraline - Major Depressive Disorder (MDD) | Phase 3 | Completed | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 786 | 2025-02-21 | 2026-10-30 |
| "A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder" CYB003, Psychological Support, Placebo - Major Depressive Disorder | Phase 3 | Completed | Cybin IRL Limited | 223 | 2024-12-17 | 2026-10-27 |
| Efficacy and Safety Study of Levomilnacipran Hydrochloride Extended-Release Capsules in Major Depressive Disorder Levomilnacipran Hydrochloride Extended-Release Capsules, Duloxetine Hydrochloride Enteric Capsules - Major Depressive Disorder (MDD) | Phase 3 | Completed | Zhejiang Huahai Pharmaceutical Co., Ltd. | 392 | 2024-10-17 | 2025-11-28 |
| Study of Lumateperone in the Treatment of Patients With Bipolar Mania Lumateperone, Placebo - Bipolar Disorder, Manic | Phase 3 | Completed | Intra-Cellular Therapies, Inc. | 351 | 2024-07-17 | 2026-07-24 |
| Study of Lumateperone in the Acute Treatment of Patients With Bipolar Mania Lumateperone, Placebo - Bipolar Disorder, Manic | Phase 3 | Completed | Intra-Cellular Therapies, Inc. | 354 | 2024-06-19 | 2026-07-24 |
| BHV-7000 Acute Treatment of Bipolar Mania BHV-7000, Placebo - Bipolar Disorder | Phase 2 / Phase 3 | Completed | Biohaven Therapeutics Ltd. | 274 | 2024-05-28 | 2025-12-16 |
| Progressing TAAR-1, Dopamine, and Norepinephrine in Depression Using Solriamfetol Solriamfetol 300 mg, Placebo - Major Depressive Disorder | Phase 3 | Completed | Axsome Therapeutics, Inc. | 346 | 2024-03-18 | 2026-01-05 |
| Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder NMRA-335140, Placebo - Major Depressive Disorder | Phase 3 | Completed | Neumora Therapeutics, Inc. | 422 | 2023-12-21 | 2026-07-06 |
| Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder NMRA-335140, Placebo - Major Depressive Disorder | Phase 3 | Completed | Neumora Therapeutics, Inc. | 430 | 2023-12-20 | 2026-07-06 |
| Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder NMRA-335140, Placebo - Major Depressive Disorder | Phase 3 | Completed | Neumora Therapeutics, Inc. | 383 | 2023-09-20 | 2025-11-26 |
| OptimizeD Pilot Study Healthy Activity Program (HAP), Antidepressant medication (ADM) - Depression, Depressive Disorder | Phase 3 | Completed | Harvard Medical School (HMS and HSDM) | 76 | 2023-08-01 | 2024-04-09 |
| Pramipexole for Anhedonic Depression Pramipexole, Placebo - Psychiatric Disorders Mood, Anhedonia | Phase 3 | Completed | Region Skane | 85 | 2023-02-08 | 2026-04-28 |
| Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD Psilocybin - Treatment Resistant Depression | Phase 3 | Completed | COMPASS Pathways | 258 | 2023-01-24 | 2026-08-10 |
| A Study of Aticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy Aticaprant, Placebo - Depressive Disorder, Major, Anhedonia | Phase 3 | Completed | Janssen Research & Development, LLC | 444 | 2022-12-06 | 2026-02-13 |
| Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia and Bipolar Disorder (SERENITY III) BXCL501, Matching Placebo - Agitation,Psychomotor, Bipolar I Disorder | Phase 3 | Completed | BioXcel Therapeutics Inc | 452 | 2022-11-21 | 2026-08-07 |
| Treating Immuno-metabolic Depression With Anti-inflammatory Drugs Celecoxib 400mg, Placebo - Depressive Disorder, Major, Inflammation | Phase 3 | Completed | Amsterdam UMC, location VUmc | 94 | 2022-09-28 | 2026-09-21 |
| Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25 Cramp Bites by Aunt Flo's Kitchen - Dysmenorrhea Primary, Dysmenorrhea | Phase 2 / Phase 3 | Completed | Cornell University | 12 | 2022-07-21 | 2024-04-12 |
| A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy Aticaprant, Placebo - Depressive Disorder, Major, Anhedonia | Phase 3 | Completed | Janssen Research & Development, LLC | 513 | 2022-06-22 | 2025-11-06 |
| Sertraline Versus Escitalopram in South Asian Participants With Moderate to Severe Major Depressive Disorder Sertraline, Escitalopram - Major Depressive Disorder | Phase 3 | Completed | KRL Hospital, Islamabad | 744 | 2022-06-01 | 2023-07-18 |
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Depressive Disorder, Major (322) · Depression (178) · Bipolar Disorder (177) · Depressive Disorder (63) · Mania (32) · Depressive Disorder, Treatment-Resistant (22) · Psychotic Disorders (21) · Anxiety Disorders (15) · Mental Disorders (15) · Schizophrenia (14) · Depression, Postpartum (12) · Sleep Initiation and Maintenance Disorders (10) · Affective Disorders, Psychotic (6) · Dysthymic Disorder (5)
Mental Disorders (544) · Depressive Disorder (319) · Behavior (188) · Behavioral Symptoms (182) · Bipolar and Related Disorders (177) · Pathological Conditions, Signs and Symptoms (63) · Nervous System Diseases (59) · Signs and Symptoms (50) · Neurologic Manifestations (45) · Neurobehavioral Manifestations (42) · Schizophrenia Spectrum and Other Psychotic Disorders (30) · Urogenital Diseases (17) · Pathologic Processes (16) · Female Urogenital Diseases and Pregnancy Complications (14)
Quetiapine Fumarate (34) · Escitalopram (33) · Vortioxetine (32) · Duloxetine Hydrochloride (30) · Sertraline (23) · Aripiprazole (22) · Fluoxetine (19) · Risperidone (18) · Valproic Acid (16) · Lamotrigine (14) · Lithium (14) · Lurasidone Hydrochloride (14) · Paroxetine (13) · Antidepressive Agents (12) · Olanzapine (11)
AstraZeneca (29) · Eli Lilly and Company (25) · Forest Laboratories (21) · Otsuka Pharmaceutical Development & Commercialization, Inc. (21) · GlaxoSmithKline (20) · Sanofi (20) · Wyeth is now a wholly owned subsidiary of Pfizer (20) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (18) · H. Lundbeck A/S (17) · Takeda (16) · Janssen Research & Development, LLC (13) · Sumitomo Pharma America, Inc. (11) · Intra-Cellular Therapies, Inc. (9) · Merck Sharp & Dohme LLC (9) · Pfizer (9)
United States (343) · Canada (78) · Germany (56) · Russia (50) · France (48) · Poland (48) · Bulgaria (43) · Japan (38) · South Africa (37) · Slovakia (35) · Czechia (34) · Mexico (33) · Ukraine (33) · Spain (32) · Finland (30)
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