11 completed, 4 unknown, 2 terminated, 1 enrolling by invitation. 9 Not applicable, 2 Phase 2, 2 Phase 3, 1 Early Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 5, Unknown 2, Enrolling by invitation 1, Not yet recruiting 1 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
| Phase 3 | 2 | Completed 2 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Miosis: new trials by email Literature Review of Miosis trials Research Report on Miosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adjusted Study Protocol: Within-Subject Paired-Eye Design Comparing Pilocarpine 0.1%, Phentolamine 0.75%, and Combination Therapy for Cyclopentolate Reversal in Children Use of phentolamine eye drops to reverse cycloplegia, Pilocarpine 0.1%, Combination of pilocarpine 0.1% and phentolamine 0.75% - Pupillary Constriction, Accomodation | Not applicable | Not yet recruiting | Mansoura University | 60 | 2025-06-01 | 2025-06-10 |
| Evaluation of NV701 (Pilocarpine 1.25%) Compared With Vuity (Pilocarpine 1.25%) on Pupil Size in Subjects With Presbyopia NV701, Pilocarpine 1.25% Eye drop - Pupil Constriction | Early Phase 1 | Completed | Novus Vision LLC | 55 | 2025-01-30 | 2025-09-05 |
| Comparative Study on Changes in Anterior Chamber Cytokines, Oxidative Stress, and Pupil Size After LenSx and Z8 Femtosecond Lasers LenSx, Z8 - Cataract | Not applicable | Enrolling by invitation | Second Affiliated Hospital, Zhejiang University, School of Medicine | 80 | 2024-08-01 | 2024-10-21 |
| Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Presbyopia Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Placebo (Vehicle) ophthalmic solution - Presbyopia, Near Vision | Phase 3 | Completed | Corxel Pharmaceuticals | 300 | 2023-09-27 | 2025-03-03 |
| Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age Remifentanil Hydrochloride, Pupillometry measurement - Opioid Toxicity, Pupillary Miosis | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 10 | 2022-10-01 | 2025-05-02 |
| Cytokines in Femtosecond Laser-assisted Cataract Surgery aqueous humor collection - Cataract | Not applicable | Completed | Second Affiliated Hospital, Zhejiang University, School of Medicine | 40 | 2022-01-01 | 2022-08-23 |
| Cerebral Blood Flow Evaluation With Trancranial Doppler After Interscalene Nerve Block TCD Measurement - Regional Anesthesia, Horner Syndrome | Terminated | Stanford University | 10 | 2021-03-04 | 2021-09-16 | |
| Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Complicated and Combined Cataract Surgery bandage contact lenses(PureVision; Bausch & Lomb Inc., Rochester, NY), phacoemulsification - Cataract, Lens Subluxation | Not applicable | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 30 | 2020-03-13 | 2021-04-05 |
| Nepafenac Versus Ketorolac Eye Drops in Prevention of Intraoperative Miosis During Cataract Surgery Ketorolac Ophthalmic, Nepafenac Ophthalmic, Cyclopentolate Ophthalmic - Cataract, Miosis | Phase 2 | Unknown | Assiut University | 75 | 2019-03-01 | 2019-02-25 |
| Exploration of Pupil Dilation in Horner's Patients Taking Flomax 10% phenylephrine - Horner Syndrome | Phase 4 | Terminated | Denver Health and Hospital Authority | 1 | 2018-09-21 | 2022-03-03 |
| The Effects of Horner's Syndrome Developing After Interscalene Brachial Plexus Block on Autonomic Nervous Activity Interscalene brachial plexus block, 0.75% ropivacaine - Brachial Plexus Block, Horner Syndrome | Completed | Daegu Catholic University Medical Center | 48 | 2018-06-18 | 2021-06-18 | |
| Pupillometry in Horner's Syndrome Automated pupillometry - Horner's Syndrome, Stroke | Not applicable | Unknown | University of Zurich | 135 | 2017-02-15 | 2021-01-11 |
| Evaluation of an Iris Dilatation Ring in Cataract Surgery (ADICC-ID) Bhattacharjee ring - Small Pupil | Not applicable | Completed | Fondation Ophtalmologique Adolphe de Rothschild | 25 | 2015-04-14 | 2018-08-31 |
| Efficacy of the Canabrava/s Pupil Expansion Device in Cataract Surgery With Small Pupils: The First 30 Cases Cana's Ring - Small Pupil, Cataract | Not applicable | Completed | Santa Casa de Misericórdia de Belo Horizonte | 29 | 2014-09-01 | 2017-07-02 |
| Clinical Efficacy of Supraclavicular Block for Arthroscopic Shoulder Surgery Supraclavicular block, Interscalene block - Horner's Syndrome | Not applicable | Completed | Daegu Catholic University Medical Center | 104 | 2013-09-01 | 2014-04-08 |
| Use of APX 100 Device for Small-pupil Cataract Surgery and Intraoperative Floppy-iris Syndrome Pupil expansion with APX 100 device - Miosis Disorder, Intraoperative Floppy Iris Syndrome | Not applicable | Completed | Meir Medical Center | 6 | 2012-09-01 | 2015-04-16 |
| Horner's SD After Thoracic Epidural Block thoracic epidural anesthesia, mastectomy, Ropivacaine - Horner's Syndrome | Completed | Soonchunhyang University Hospital | 450 | 2010-09-01 | 2014-05-05 | |
| Outcome of Small Pupil Phacotrabeculectomy in Persons With Glaucoma and Cataract Glaucoma, Cataract | Unknown | Aravind Medical Research Foundation | 70 | 2007-03-01 | 2007-02-13 | |
| Clinical Factors Associated Floppy Iris Pupil Constriction, Iris Floppiness | Completed | Baskent University | 500 | 2005-11-01 | 2007-05-14 |
Cataract (6) · Horner Syndrome (6) · Corneal Opacity (1) · Diabetes Mellitus (1) · Dry Eye Syndromes (1) · Exfoliation Syndrome (1) · Eye Diseases (1) · Glaucoma (1) · Hypertension (1) · Lens Subluxation (1) · Myopia (1) · Pain (1) · Presbyopia (1) · Respiratory Insufficiency (1)
Nervous System Diseases (19) · Neurologic Manifestations (19) · Pathological Conditions, Signs and Symptoms (19) · Pupil Disorders (19) · Signs and Symptoms (19) · Eye Diseases (18) · Autonomic Nervous System Diseases (6) · Brain Diseases (6) · Cavernous Sinus Syndromes (6) · Central Nervous System Diseases (6) · Lens Diseases (6) · Cardiovascular Diseases (2) · Vascular Diseases (2) · Cerebrovascular Disorders (1)
Ophthalmic Solutions (2) · Ropivacaine (2) · Fentanyl (1) · Mastectomy (1) · Phacoemulsification (1) · Phenylephrine (1) · Pilocarpine (1) · Propofol (1) · Remifentanil (1)
Second Affiliated Hospital, Zhejiang University, School of Medicine (3) · Daegu Catholic University Medical Center (2) · Aravind Medical Research Foundation (1) · Assiut University (1) · Baskent University (1) · Corxel Pharmaceuticals (1) · Denver Health and Hospital Authority (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Mansoura University (1) · Meir Medical Center (1) · Novus Vision LLC (1) · Santa Casa de Misericórdia de Belo Horizonte (1) · Soonchunhyang University Hospital (1) · Stanford University (1) · University of California, San Francisco (1)
China (4) · United States (4) · South Korea (3) · France (1) · Israel (1) · Switzerland (1) · Turkey (Türkiye) (1)
Anna Maria Bombardieri, MD, PhD (1) · Cristos Ifantides, MD (1) · Ehud Assia, M.D (1) · Gloria Sun (1) · Jong Hae Kim, MD (1) · JongHae Kim, Master (1) · Konrad P Weber, MD (1) · Rachel Eshima McKay, MD (1) · Ramasami Krishnadas, MD (1) · Rana Altan-Yaycioglu, MD (1) · Sergio Canabrava, MD (1) · Yonca A Akova, MD (1)