47 completed, 13 unknown, 5 terminated, 2 not yet recruiting. 26 Not applicable, 13 Phase 4, 12 Phase 3, 7 Phase 2, 2 Phase 1.
Follow Pupil Disorders: new trials by email Literature Review of Pupil Disorders trials Research Report on Pupil Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacodynamics of a Fixed Dose Combination of 0.34% Tropicamide and 2.5% Phenylephrine Hydrochloride, Eye Drop, Solution IMP 08P2002F0, Mydriasert® insert - Mydriasis | Phase 1 / Phase 2 | Completed | Unither Pharmaceuticals, France | 20 | 2025-11-01 | 2026-06-17 |
| Adjusted Study Protocol: Within-Subject Paired-Eye Design Comparing Pilocarpine 0.1%, Phentolamine 0.75%, and Combination Therapy for Cyclopentolate Reversal in Children Use of phentolamine eye drops to reverse cycloplegia, Pilocarpine 0.1%, Combination of pilocarpine 0.1% and phentolamine 0.75% - Pupillary Constriction, Accomodation | Not applicable | Not yet recruiting | Mansoura University | 60 | 2025-06-01 | 2025-06-10 |
| Anisocoria in the Intensive Care Unit (AICU Study) Anisocoria | Active not recruiting | University Hospital, Basel, Switzerland | 920 | 2025-03-01 | 2026-06-17 | |
| Evaluation of NV701 (Pilocarpine 1.25%) Compared With Vuity (Pilocarpine 1.25%) on Pupil Size in Subjects With Presbyopia NV701, Pilocarpine 1.25% Eye drop - Pupil Constriction | Early Phase 1 | Completed | Novus Vision LLC | 55 | 2025-01-30 | 2025-09-05 |
| The Correlation Between Pupil Size and Retinal Nerve Fibers Changes in Pseudoexfoliation Syndrome. optical coherence tomography - Pseudoexfoliation Syndrome | Not yet recruiting | Assiut University | 33 | 2024-12-01 | 2024-09-19 | |
| Comparison of 4 Methods of Eye Drops for Pupil Dilation in Diabetic Patients 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 1 drop of 0.5% tetracaine and 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 3 drops of a 0.8% tropicamide + 5% phenylephrine combination - Diabetes (DM), Retinopathy, Diabetic | Not applicable | Completed | Burapha University | 84 | 2024-11-04 | 2026-03-27 |
| Efficacy of the MydCombi on Pupillary Dilation in Pediatric and Adult Patients MydCombi Device, MydCombi Drug - Dilation, Pupil Reaction Absent | Phase 4 | Completed | University of California, San Francisco | 70 | 2024-10-01 | 2026-09-22 |
| Comparative Study on Changes in Anterior Chamber Cytokines, Oxidative Stress, and Pupil Size After LenSx and Z8 Femtosecond Lasers LenSx, Z8 - Cataract | Not applicable | Enrolling by invitation | Second Affiliated Hospital, Zhejiang University, School of Medicine | 80 | 2024-08-01 | 2024-10-21 |
| Comparing Efficacy and Safety of CTO0303 in Pediatric Subjects CTO0303-A, CTO0303-B, CTO0303-C - Pupillary Dilation Effect During Cycloplegic Refraction | Phase 2 / Phase 3 | Unknown | Taejoon Pharmaceutical Co., Ltd. | 156 | 2024-05-09 | 2024-09-24 |
| Comfort Level in Premature Infants Undergoing Retinopathy of Prematurity Screening standard phototherapy eye patches - Premature, Retinopathy of Prematurity | Not applicable | Completed | Istanbul Nisantasi University | 90 | 2024-01-01 | 2025-06-12 |
| Safety and Efficacy of Fixed Combination Phenylephrine-Tropicamide for Pupil Dilation MydCombi - Mydriasis | Phase 4 | Completed | Eyenovia Inc. | 30 | 2023-11-28 | 2024-04-18 |
| Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Presbyopia Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Placebo (Vehicle) ophthalmic solution - Presbyopia, Near Vision | Phase 3 | Completed | Corxel Pharmaceuticals | 300 | 2023-09-27 | 2025-03-03 |
| Measuring Relative Afferent Pupillary Defect Swinging Light test, Virtual Reality Head-Mounted Display (VR HMD) - Relative Afferent Pupil Defect (RAPD) | Not applicable | Terminated | The University of Texas Medical Branch, Galveston | 71 | 2023-05-04 | 2026-06-03 |
| Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age Remifentanil Hydrochloride, Pupillometry measurement - Opioid Toxicity, Pupillary Miosis | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 10 | 2022-10-01 | 2025-05-02 |
| Wearing-Off Period of Pharmacological Dilation and Anisocoria Tropicamide, 1% Pilocarpine, Proparacaine Hydrochloride - Anisocoria | Phase 4 | Completed | Prisma Health-Upstate | 11 | 2022-04-01 | 2023-03-07 |
| The Effect of Eyedrop Size on Pupillary Dilation Using the Nanodropper Bottle Adapter Nanodropper, Standard eye drop bottle - Medication Delivery, Eye Drop Delivery | Not applicable | Completed | Sutter Health | 54 | 2022-01-04 | 2024-11-15 |
| Cytokines in Femtosecond Laser-assisted Cataract Surgery aqueous humor collection - Cataract | Not applicable | Completed | Second Affiliated Hospital, Zhejiang University, School of Medicine | 40 | 2022-01-01 | 2022-08-23 |
| Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis in Pediatric Subjects Phentolamine Ophthalmic Solution 0.75%, Phentolamine Ophthalmic Solution Vehicle - Mydriasis, Dilation | Phase 3 | Completed | Opus Genetics, Inc | 23 | 2021-12-17 | 2026-10-30 |
| Cochlear Implanted Listening Effort and Hearing Attention Forced choice psychoacoustic task for the evaluation of modulation detection performance and selective auditory attention. (for both arm), Measurement of the pupil diameter for the evaluation of listening effort during speech perception - Sensorineural Hearing Loss | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 170 | 2021-12-08 | 2025-01-13 |
| Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis (MIRA-3) Phentolamine Ophthalmic Solution 0.75%, Phentolamine Ophthalmic Solution Vehicle - Mydriasis, Dilation | Phase 3 | Completed | Opus Genetics, Inc | 368 | 2021-11-18 | 2026-10-30 |
Showing 20 of 71. Sign in to see all of them.
Mydriasis (37) · Cataract (13) · Miosis (13) · Dilatation, Pathologic (7) · Horner Syndrome (6) · Pain (4) · Retinopathy of Prematurity (4) · Diabetes Mellitus (3) · Exfoliation Syndrome (3) · Glaucoma (3) · Anisocoria (2) · Eye Diseases (2) · Premature Birth (2) · Aphakia (1)
Eye Diseases (69) · Pathological Conditions, Signs and Symptoms (45) · Signs and Symptoms (39) · Neurologic Manifestations (38) · Nervous System Diseases (36) · Lens Diseases (14) · Brain Diseases (8) · Central Nervous System Diseases (8) · Pathological Conditions, Anatomical (7) · Autonomic Nervous System Diseases (6) · Cavernous Sinus Syndromes (6) · Miosis (6) · Retinal Diseases (5) · Cardiovascular Diseases (4)
Phenylephrine (11) · Tropicamide (9) · Ophthalmic Solutions (4) · Pilocarpine (2) · Propofol (2) · Ropivacaine (2) · Anesthetics (1) · Atropine (1) · Brimonidine Tartrate (1) · Cyclopentolate (1) · Epinephrine (1) · Fentanyl (1) · Immuvac (1) · Ketorolac (1) · Lidocaine (1)
Eyenovia Inc. (5) · Opus Genetics, Inc (4) · Khon Kaen University (3) · Second Affiliated Hospital, Zhejiang University, School of Medicine (3) · Aristotle University Of Thessaloniki (2) · Assistance Publique - Hôpitaux de Paris (2) · Assiut University (2) · Daegu Catholic University Medical Center (2) · The University of Texas Medical Branch, Galveston (2) · University of California, San Francisco (2) · Aravind Medical Research Foundation (1) · Baskent University (1) · Basque Health Service (1) · Burapha University (1) · Cairo University (1)
United States (19) · China (6) · South Korea (5) · Thailand (4) · France (3) · Greece (3) · Turkey (Türkiye) (3) · Egypt (2) · Israel (2) · Spain (2) · Switzerland (2) · Austria (1) · Brazil (1) · Canada (1) · Germany (1)
Tsontcho Ianchulev, MD, MPH (3) · Yosanan Yospaiboon, M.D. (3) · Alexandre P Costa, Pinto (1) · Amirhossein Vejdani, M.D. (1) · Anna Maria Bombardieri, MD, PhD (1) · Bakulesh M Khamar, M.S. Ophthalmology (1) · Charles Slonim, MD (1) · Cristos Ifantides, MD (1) · Ehud Assia, M.D (1) · Erika M. Espino-Torres, MD (1) · George Spaeth, MD (1) · Gerrit Alexander Schubert, Prof. (1)
PMID 41743463, PMID 17205877, PMID 18779478, PMID 19485285, PMID 20462091, PMID 22368443, PMID 25560203, PMID 29189318, PMID 32126990, PMID 33549502, PMID 33633016, PMID 34654903, PMID 34655377, PMID 35428316, PMID 37158245, PMID 37573155, PMID 38549070, PMID 39571502, PMID 39724200, PMID 41159095, PMID 41338301