16 completed, 7 unknown, 6 terminated, 4 recruiting. 17 Not applicable, 2 Phase 2, 2 Phase 4, 1 Phase 1, 1 Phase 3.
Follow Corneal Opacity: new trials by email Literature Review of Corneal Opacity trials Research Report on Corneal Opacity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Losartan for Corneal Fibrosis Topical losartan, Placebo Control - Corneal Scarring Fibrosis | Not applicable | Recruiting | Universidad Autonoma de Nuevo Leon | 46 | 2026-02-12 | 2026-05-08 |
| PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus Schwind AMARIS excimer laser, Corneal collagen crosslinking epi-off accelerated - Keratoconus | Not applicable | Recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 50 | 2025-09-01 | 2026-01-28 |
| Clinical Outcomes of the Gore Synthetic Cornea Device GORE Synthetic Cornea Device - Corneal Opacity | Not applicable | Active not recruiting | W.L.Gore & Associates | 10 | 2024-08-19 | 2026-07-16 |
| Study to Evaluate the Clinical Safety and Performance of the CorNeat KPro for Treatment of Corneal Blindness CorNeat KPro - Corneal Disease, Corneal Opacity | Not applicable | Terminated | CorNeat Vision Ltd. | 15 | 2024-06-27 | 2026-05-07 |
| Evaluation Of Deep Anterior Lamellar Keratoplasty By Anterior Segment Ocular Coherence Tomography deep anterior lamellar keratoplasty - Keratoconus, Cornea | Unknown | Assiut University | 20 | 2022-05-01 | 2022-04-26 | |
| Photorefractive Keratectomy (PRK) : Comparison of Corneal Haze Between Two Modes of De-epithelialisation (Laser Versus Manual Alcohol) TransPRK, Alcohol PRK - Myopia, Astigmatism | Not applicable | Terminated | Fondation Ophtalmologique Adolphe de Rothschild | 71 | 2022-02-09 | 2025-12-08 |
| Characteristics of Trachomatous Corneal Opacity in Fayoum University Hospital Corneal topography - Corneal Opacity | Completed | Omar Said | 50 | 2022-02-01 | 2023-08-21 | |
| Effect of Ectoine After Photorefractive Keratectomy (PRK). Ectohylo (R) eye drops - Photorefractive Keratectomy, Corneal Haze | Unknown | Tanta University | 15 | 2022-01-01 | 2022-04-06 | |
| First in Human (FIH) Study to Assess Safety and Efficacy of the CorNeat KPro for the Treatment of Corneal Blindness CorNeat KPro - Corneal Disease, Corneal Opacity | Not applicable | Terminated | CorNeat Vision Ltd. | 10 | 2021-01-03 | 2024-09-24 |
| The Effect of Thyroid Hormon Levels on the Corneal Measures Thyroid Disorder, Corneal Opacity | Completed | Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital | 60 | 2020-06-15 | 2021-02-16 | |
| Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Complicated and Combined Cataract Surgery bandage contact lenses(PureVision; Bausch & Lomb Inc., Rochester, NY), phacoemulsification - Cataract, Lens Subluxation | Not applicable | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 30 | 2020-03-13 | 2021-04-05 |
| Biomarker for Homozygous Familial Hypercholesterolemia (BioHoFH) Lipoprotein Lipase Deficiency, Inborn Error of Lipid Metabolism | Withdrawn | CENTOGENE GmbH Rostock | 2018-08-20 | 2023-02-13 | ||
| OCT in Diagnosis of Irregular Corneas Optical Coherence Tomography - Keratoconus, Corneal Opacity | Recruiting | Oregon Health and Science University | 445 | 2018-05-01 | 2025-09-09 | |
| Refractive Transepithelial Photo-keratectomy (T-PKR) in High Myopia Ophthalmopathy, Myopia | Completed | Centre Hospitalier Régional Metz-Thionville | 38 | 2018-01-01 | 2023-04-13 | |
| Implantable Intraocular Pressure Sensor for Glaucoma Monitoring in Patients With Boston Keratoprosthesis Type 1 EyeMate - Glaucoma, Blindness, Acquired | Not applicable | Withdrawn | Centre hospitalier de l'Université de Montréal (CHUM) | 2016-11-01 | 2018-02-05 | |
| Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant - Limbal Stem Cell Deficiency | Phase 1 / Phase 2 | Completed | Massachusetts Eye and Ear Infirmary | 23 | 2016-08-01 | 2025-01-15 |
| Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP closed PKP under topical anesthesia, open-sky PKP under retrobulbar anesthesia, Anti-Rejection Agents - Corneal Opacity, Keratitis, Herpetic | Not applicable | Unknown | Wenzhou Medical University | 60 | 2015-12-01 | 2016-07-07 |
| Safety and Effectiveness of the RHCIII-MPC Biosynthetic Cornea in Patients Requiring Anterior Lamellar Keratoplasty RHCIII-MPC cornea, Donor cornea - Leukoma | Not applicable | Completed | L.V. Prasad Eye Institute | 2 | 2015-05-01 | 2018-08-09 |
| Phacoemulsification in Patients With Corneal Opacities Phacoemulsification in eyes with corneal opacities - Senile Cataract | Completed | Assiut University | 10 | 2015-01-01 | 2021-08-20 | |
| Loteprednol vs. Prednisolone and Fluorometholone Loteprednol Etabonate 0.5% Oph Gel, Prednisolone Acetate 1% Oph Susp - Intraocular Pressure, Corneal Opacity | Phase 4 | Completed | University of Utah | 131 | 2014-09-19 | 2021-05-26 |
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Corneal Diseases (6) · Corneal Injuries (6) · Keratoconus (6) · Corneal Dystrophies, Hereditary (4) · Myopia (4) · Astigmatism (2) · Cataract (2) · Corneal Ulcer (2) · Hyperopia (2) · Keratitis (2) · Keratitis, Herpetic (2) · Agenesis of Corpus Callosum (1) · Aphakia (1) · Arcus Senilis (1)
Eye Diseases (36) · Corneal Diseases (31) · Nervous System Diseases (8) · Pathological Conditions, Signs and Symptoms (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Craniocerebral Trauma (6) · Facial Injuries (6) · Genetic Diseases, Inborn (6) · Signs and Symptoms (6) · Trauma, Nervous System (6) · Wounds and Injuries (6) · Eye Injuries (5) · Neurologic Manifestations (5) · Eye Diseases, Hereditary (4) · Eye Infections (4)
Keratoplasty, Penetrating (3) · Mitomycin (2) · Phacoemulsification (2) · Tomography, Optical Coherence (2) · Anesthesia (1) · Anesthesia, General (1) · Anti-Inflammatory Agents (1) · Corneal Topography (1) · Ethanol (1) · Fluorometholone (1) · Ketorolac (1) · Lasers, Semiconductor (1) · Losartan (1) · Loteprednol Etabonate (1) · Ophthalmic Solutions (1)
Oregon Health and Science University (6) · Assiut University (2) · CorNeat Vision Ltd. (2) · The S.N. Fyodorov Eye Microsurgery State Institution (2) · Baskent University (1) · Baylor Research Institute (1) · CENTOGENE GmbH Rostock (1) · Center For Excellence In Eye Care (1) · Centre Hospitalier Régional Metz-Thionville (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Federal University of São Paulo (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Insel Gruppe AG, University Hospital Bern (1) · Instituto de Oftalmología Fundación Conde de Valenciana (1) · L.V. Prasad Eye Institute (1)
United States (13) · France (4) · Mexico (3) · Canada (2) · China (2) · Egypt (2) · India (2) · Israel (2) · Netherlands (2) · Turkey (Türkiye) (2) · Brazil (1) · Germany (1) · Italy (1) · Russia (1) · Sri Lanka (1)
Bibiana Reiser, MD (2) · David Huang, MD, PhD (2) · Arturo Ramirez Miranda, MD (1) · Boris Malyugin, MD,PhD,prof. (1) · David Goldblum, MD (1) · Donna Murdoch, Ph.D. (1) · Ester S Yamazaki, MD (1) · John B Cason, M.D. (1) · Karim Mohamed-Noriega, Dr. med. (1) · Luca Menabuoni, MD (1) · Mark Mifflin, MD (1) · Mauro S Campos, MD (1)
PMID 19097643, PMID 10551286, PMID 15288984, PMID 17583820, PMID 18642207, PMID 20435595, PMID 20847116, PMID 21109229, PMID 21492957, PMID 21705880, PMID 24374070, PMID 25322173, PMID 27412098, PMID 28012874, PMID 29858043, PMID 30262982, PMID 31765363, PMID 31883529, PMID 31915973, PMID 38549070, PMID 40038272, PMID 40152603, PMID 40810416
R01EY018184 (4), U54NS065768 (1)