11 completed, 3 recruiting. 6 Phase 1, 6 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 5, Recruiting 1 |
| Phase 3 | 6 | Completed 5, Recruiting 1 |
| Phase 2 | 3 | Recruiting 2, Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety and Tolerability of Different Doses of CX11 Tablets CX11, Placebo - Obesity & Overweight | Phase 1 | Recruiting | Corxel Pharmaceuticals | 90 | 2026-05-11 | 2026-06-17 |
| A Food-Effect Study of CX11 in Healthy Participants CX11 (VCT220) - Obesity & Overweight, Type 2 Diabetes | Phase 1 | Completed | Vincentage Pharma Co., Ltd | 32 | 2026-03-04 | 2026-10-13 |
| A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus CX11, Placebo - Type II Diabetes Mellitus | Phase 2 | Recruiting | Corxel Pharmaceuticals | 240 | 2026-02-06 | 2026-09-15 |
| A Study to Evaluate the Efficacy and Safety of CX11 Tablets in Overweight/Obese Participants CX11, Placebo - Obesity | Phase 2 | Completed | Corxel Pharmaceuticals | 250 | 2025-06-17 | 2026-05-28 |
| Optimizing Reperfusion to Improve Outcomes and Neurologic Function JX10, Placebo - Acute Ischemic Stroke | Phase 2 / Phase 3 | Recruiting | Corxel Pharmaceuticals | 740 | 2025-05-15 | 2026-09-21 |
| Safety, Tolerability and Pharmacokinetics of LNZ101 and LNZ100 Ophthalmic Solutions in Healthy Adult Chinese With Presbyopia LNZ101 (Aceclidine /Brimonidine) ophthalmic solution, LNZ100 (Aceclidine) ophthalmic solution, Placebo (Vehicle) ophthalmic solution - Presbyopia | Phase 1 | Completed | Corxel Pharmaceuticals | 21 | 2024-03-04 | 2024-04-23 |
| An Open-Label Study of Aficamten for Chinese Patients With Symptomatic oHCM Aficamten - Obstructive Hypertrophic Cardiomyopathy | Phase 3 | Completed | Corxel Pharmaceuticals | 40 | 2023-11-14 | 2026-01-21 |
| Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Presbyopia Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Placebo (Vehicle) ophthalmic solution - Presbyopia, Near Vision | Phase 3 | Completed | Corxel Pharmaceuticals | 300 | 2023-09-27 | 2025-03-03 |
| A Study of Etripamil in Healthy Subjects Etripamil Nasal Spray 70mg, Placebo - Healthy Chinese Subjects | Phase 1 | Completed | Corxel Pharmaceuticals | 12 | 2023-03-07 | 2023-04-10 |
| Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of OC-01 in Adult Chinese With Dry Eye Disease Varenicline Tartrate Nasal Spray - Dry Eye Disease | Phase 1 | Completed | Corxel Pharmaceuticals | 9 | 2022-12-07 | 2023-05-01 |
| Clinical Trial to Evaluate the Efficacy and Safety of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Varenicline Tartrate Nasal Spray, Placebo (vehicle) - Dry Eye Disease | Phase 3 | Completed | Corxel Pharmaceuticals | 340 | 2022-07-22 | 2023-04-25 |
| Efficacy and Safety Study of Etripamil Nasal Spray Self-Administration for the Termination of Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia Etripamil NS 70 mg, Placebo - Tachycardia, Supraventricular, Paroxysmal Supraventricular Tachycardia | Phase 3 | Completed | Corxel Pharmaceuticals | 500 | 2022-06-30 | 2026-10-22 |
| Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM Aficamten (5 mg, 10 mg, 15 mg, and 20 mg), Placebo to match aficamten - Obstructive Hypertrophic Cardiomyopathy (oHCM) | Phase 3 | Completed | Cytokinetics | 282 | 2022-02-01 | 2026-03-03 |
| Safety, Tolerability and Pharmacokinetics Study of CK-3773274 CK-3773274, Placebo - Obstructive Hypertrophic Cardiomyopathy, Healthy Adult Subjects | Phase 1 | Completed | Corxel Pharmaceuticals | 28 | 2021-04-10 | 2025-01-24 |
Cardiomyopathy, Hypertrophic (3) · Obesity (3) · Overweight (3) · Diabetes Mellitus, Type 2 (2) · Dry Eye Syndromes (2) · Presbyopia (2) · Tachycardia, Supraventricular (2) · Tachycardia, Ventricular (2) · Eye Diseases (1) · Hypoglycemia (1) · Ischemic Stroke (1) · Miosis (1) · Myopia (1) · Tachycardia (1) · Weight Loss (1)
Nasal Sprays (2) · Ophthalmic Solutions (2) · Brimonidine Tartrate (1) · aceclidine (1)
China (11) · United States (5) · France (2) · Germany (2) · Hungary (2) · Italy (2) · Poland (2) · Portugal (2) · Spain (2) · United Kingdom (2) · Belgium (1) · Bulgaria (1) · Canada (1) · Czechia (1) · Denmark (1)
Changsheng Ma (1) · Gloria Sun (1) · Larry Li, Doctor (1) · Lihang QI (1) · Xiaowen Chen (1) · Yuewen XI (1) · Yuhui Zhang, MD (1)
PMID 37680714, PMID 38032573, PMID 38739079, PMID 39056349, PMID 39217447, PMID 39217556, PMID 39217563, PMID 39217569, PMID 39230885, PMID 39352339, PMID 40200648, PMID 40910168, PMID 41347307, PMID 42624353