33 completed, 4 unknown, 3 recruiting, 3 withdrawn. 51 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 51 | Completed 33, Unknown 4, Recruiting 3, Withdrawn 3, Active not recruiting 2, Enrolling by invitation 2, Not yet recruiting 2, Terminated 2 |
Follow Migraine without Aura: new trials by email Literature Review of Migraine without Aura trials Research Report on Migraine without Aura
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Using Virtual Reality to Teach Mindfulness to People With Migraine ACT therapy delivered by REACT NeuroVR headset - Migraine Disorders, Migraine With Aura | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 160 | 2026-09-30 | 2026-09-30 |
| A Comprehensive Digital Care Program for Migraine Management Neuromodulation Wearable Device, Migraine Digital Care Program - Migraine, Migraine With Aura | Not applicable | Enrolling by invitation | Hinge Health, Inc | 140 | 2026-07-09 | 2026-09-17 |
| Preventive Role of Melatonin and Propranolol Administration in Pediatric Migraine Melatonin, Propranolol - Migraine Disorders | Not applicable | Enrolling by invitation | Nishtar Medical University | 60 | 2026-06-10 | 2026-08-03 |
| App-Based Migraine Treatment: The Health enSuite Study Health enSuite Headache - Migraine, Migraine With Aura | Not applicable | Active not recruiting | IWK Health Centre | 415 | 2026-02-15 | 2026-11-05 |
| Myotensive Extraocular Muscle Techniques Added to Manual Therapy for Migraine Without Aura Myotensive Extraocular Muscle Techniques + Manual Therapy, Standard Manual Therapy - Migraine Without Aura | Not applicable | Not yet recruiting | Facultad de Enfermería, Fisioterapia y Podología (FEFP) | 84 | 2026-01-08 | 2025-11-28 |
| Healthy Living Partnerships for Veterans With Migraine Intensive Lifestyle Intervention - Migraine, Migraine Disorders | Not applicable | Withdrawn | Wake Forest University Health Sciences | 2025-06-01 | 2025-07-02 | |
| Trial Designs for Evaluating Migraine Treatment Active drug for acute migraine treatment, Placebo Oral Tablet - Migraine With Aura, Migraine Without Aura | Not applicable | Recruiting | University of Aarhus | 128 | 2024-11-13 | 2026-04-13 |
| BE WELL With Migraine: Brain Education and WELLness With Migraine Brain Education and WELLness with Migraine Group A, Brain Education and WELLness with Migraine Group B - Migraine | Not applicable | Recruiting | Wake Forest University Health Sciences | 286 | 2024-07-31 | 2026-06-12 |
| Mi-Helper Transnasal Cooling for Acute Treatment of Migraine Mi-Helper - Episodic Migraine, Migraine With Aura | Not applicable | Completed | CoolTech LLC | 172 | 2023-11-15 | 2024-09-26 |
| Responding With Evidence and Access for Childhood Headaches CBT, Amitriptyline - Headache, Headache Disorders | Not applicable | Recruiting | Children's Hospital Medical Center, Cincinnati | 400 | 2023-08-22 | 2026-09-21 |
| Effect of Riocigaut on Migraine Attack Induction in People With Migraine Riociguat (BAY 63-2521), Placebo - Migraine Without Aura | Not applicable | Completed | Danish Headache Center | 22 | 2023-06-01 | 2024-07-12 |
| Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab Sildenafil, Placebo - Migraine Without Aura | Not applicable | Completed | Danish Headache Center | 16 | 2023-04-20 | 2023-10-24 |
| Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab Levcromakalim, Placebo - Migraine Without Aura | Not applicable | Completed | Danish Headache Center | 16 | 2023-03-09 | 2023-10-24 |
| Tailored Digital Treatment for Migraine I am (internet approach to migraine) - Migraine With Aura, Migraine Without Aura | Not applicable | Unknown | Vastra Gotaland Region | 200 | 2023-01-01 | 2022-11-15 |
| The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. Levcromakalim - Headache, Migraine With Aura | Not applicable | Unknown | Danish Headache Center | 20 | 2022-09-01 | 2023-03-22 |
| Brain Connectome for Acupuncture-treated Migraine Patients Real acupuncture, Sham acupuncture (placebo group) - Migraine Without Aura, Acupuncture Therapy | Not applicable | Completed | Centre Hospitalier Universitaire de Nīmes | 40 | 2022-05-27 | 2026-06-17 |
| Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine Levcromakalim, Sumatriptan, Saline - Migraine Without Aura, Headache | Not applicable | Completed | Danish Headache Center | 24 | 2022-03-15 | 2025-01-22 |
| Transnasal Cooling for Migraine CoolStat active device, CoolStat sham device - Migraine, Episodic Migraine | Not applicable | Terminated | CoolTech LLC | 24 | 2021-10-14 | 2023-09-29 |
| Digital Treatment for Migraines - a Feasibility Study I AM - Migraine With Aura, Migraine Without Aura | Not applicable | Completed | Vastra Gotaland Region | 29 | 2021-07-01 | 2023-06-22 |
| Effect of Ivabradine on Levcromakalim-Induced Symptoms in Individuals With Migraine Without Aura (ILIM) Levcromakalim, Ivabradine, Placebo - Headache, Migraine Without Aura | Not applicable | Completed | Danish Headache Center | 37 | 2021-05-11 | 2026-01-08 |
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Migraine Disorders (29) · Migraine with Aura (25) · Headache (9) · Headache Disorders (4) · Pain (3) · Headache Disorders, Primary (2) · Aneurysm (1) · Behavior (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Connective Tissue Diseases (1) · Nervous System Diseases (1) · Neurologic Manifestations (1) · Photophobia (1)
Brain Diseases (50) · Central Nervous System Diseases (50) · Nervous System Diseases (50) · Headache Disorders, Primary (49) · Headache Disorders (47) · Migraine Disorders (22) · Pathological Conditions, Signs and Symptoms (12) · Signs and Symptoms (12) · Neurologic Manifestations (11) · Pain (8) · Cardiovascular Diseases (1) · Eye Diseases (1) · Headache Disorders, Secondary (1) · Sensation Disorders (1) · Skin and Connective Tissue Diseases (1)
Pituitary Adenylate Cyclase-Activating Polypeptide (5) · Cromakalim (4) · Sodium Chloride (3) · Acupuncture Therapy (2) · Cilostazol (2) · Nitroglycerin (2) · Sumatriptan (2) · Amitriptyline (1) · Aspirin (1) · Calcitonin (1) · Calcitonin Gene-Related Peptide (1) · Cognitive Behavioral Therapy (1) · Doxycycline (1) · Educational Status (1) · Ferrosoferric Oxide (1)
Danish Headache Center (15) · Wake Forest University Health Sciences (3) · Children's Hospital Medical Center, Cincinnati (2) · CoolTech LLC (2) · Vastra Gotaland Region (2) · Ankara Yildirim Beyazıt University (1) · Ataturk University (1) · Beijing University of Chinese Medicine (1) · Bradley Katz (1) · Brigham and Women's Hospital (1) · Centre Hospitalier Universitaire de Nīmes (1) · Facultad de Enfermería, Fisioterapia y Podología (FEFP) (1) · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (1) · Glostrup University Hospital, Copenhagen (1) · Harvard University Faculty of Medicine (1)
Denmark (17) · United States (15) · China (4) · Turkey (Türkiye) (3) · France (2) · Sweden (2) · Canada (1) · Israel (1) · Italy (1) · Norway (1) · Pakistan (1) · Spain (1)
Messoud Ashina, Prof. (2) · Rebecca E Wells, MD, MPH (2) · Scott Powers, PhD (2) · Bradley J Katz, MD (1) · Chuanlong Zhou (1) · Cindy J. Fuller, Ph.D. (1) · David J Altschul, MD (1) · David Yarnitsky, Prof (1) · Faisal Amin, M.D. (1) · Fanrong Liang, Professor (1) · Henrik Schytz, MD (1) · Jill T. Jesurum, Ph.D. (1) · Licia Grazzi, MD (1)
PMID 24171782, PMID 26145718, PMID 27696633, PMID 28241154, PMID 28324697, PMID 31074005, PMID 31104505, PMID 31331265, PMID 32213509, PMID 33050719, PMID 33315046, PMID 33567890, PMID 35957963, PMID 38181724, PMID 38850034, PMID 40624944, PMID 41065019, PMID 41930571, PMID 42418214
K23AT008406 (1), R01AT011502 (1), U01AT010132 (1), UL1TR001420 (1)