12 completed, 1 not yet recruiting, 1 unknown, 1 withdrawn. 12 Not applicable, 2 Phase 4, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 12 | Completed 10, Not yet recruiting 1, Unknown 1 |
| Phase 4 | 2 | Completed 1, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
Follow Pituitary Adenylate Cyclase-Activating Polypeptide: new trials by email Literature Review of Pituitary Adenylate Cyclase-Activating Polypeptide trials Research Report on Pituitary Adenylate Cyclase-Activating Polypeptide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38 Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38), Placebo - Migraine With Aura, Migraine Aura | Not applicable | Not yet recruiting | Danish Headache Center | 21 | 2026-02-01 | 2026-01-15 |
| Platelet Rich Plasma Combined With Platelet Rich Fibrin in Management of Temporomandibular Joint Osteoarthritis Prp with prf or prp or prf - Osteoarthritis | Not applicable | Completed | Aliaa Babekir Ahmed Mohamed | 42 | 2025-03-29 | 2025-12-12 |
| Comparison of the Effects of Single Versus Triple Injections of Platelet-Rich Plasma in Patients With Knee Osteoarthritis prp injection - Knee Osteoarthritis | Not applicable | Completed | Izmir Democracy University | 80 | 2023-04-15 | 2024-05-10 |
| Migraine Induction Properties of PACAP-38 After Eptinezumab in Migraine Without Aura Patients. Eptinezumab, PACAP-38 - Migraine | Not applicable | Completed | Danish Headache Center | 38 | 2023-03-01 | 2023-12-04 |
| Hypersensitivity to PACAP-38 in Post-Traumatic Headache Pituitary adenylate cyclase activating polypeptide-38, Placebo - Post-Traumatic Headache | Not applicable | Unknown | Danish Headache Center | 21 | 2022-06-16 | 2022-06-22 |
| The Hemodynamic Effects of PACAP38 After Glibenclamide Administration in Healthy Volunteers glibenclamide, PACAP38 - Migraine, Headache | Not applicable | Completed | Danish Headache Center | 22 | 2020-10-20 | 2021-07-14 |
| Short Term Results of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure prp injection, Anrecta, sitz bath - Anal Fissure Chronic, PRP | Phase 4 | Completed | KTO Karatay University | 41 | 2019-01-01 | 2022-04-07 |
| PACAP38 Induced Headache, Migraine and Flushing in Patients With Migraine Imigran, Isotonic Saline, Pituitary adenylate cyclase-activating peptide-38 - Migraine Without Aura | Not applicable | Completed | Danish Headache Center | 37 | 2018-07-17 | 2020-06-22 |
| The Effect of PACAP27 on the Extra- and Intracerebral Arteries Assessed by Magnetic Resonance Angiography (MRA) on Healthy Volunteers PACAP27, Placebo - Headache, Migraine | Not applicable | Completed | Danish Headache Center | 18 | 2018-05-31 | 2019-02-12 |
| PACAP27 Headache Properties in Migraine Without Aura Patients PACAP27, Saline - Migraine Without Aura | Not applicable | Completed | Danish Headache Center | 20 | 2017-08-30 | 2019-01-24 |
| To Evaluate the Blockade of CGRP in Preventing PACAP-38 Induced Migraine-like Attacks With AMG 334 in Migraine Patients Erenumab, Placebo, PACAP-38 Challenge Agent - Migraine | Phase 1 | Completed | Amgen | 35 | 2015-11-11 | 2019-06-03 |
| The Effect of Histamine H1 Receptor Antagonist, Clemastin, on PACAP38 Induced Headache in Migraine Patients PACAP38 - Migraine Without Aura | Not applicable | Completed | Song Guo | 20 | 2015-02-01 | 2018-02-15 |
| PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load PACAP - Migraine Without Aura | Not applicable | Completed | Danish Headache Center | 32 | 2014-06-01 | 2015-02-10 |
| Intraarticular Platelet-rich Plasma Injections Versus Corticosteroid Injections in Primary Knee Osteoarthritis Intra-articular platelet-rich plasma, Intra-articular corticosteroid injections - Osteoarthritis | Phase 4 | Withdrawn | King Hamad University Hospital, Bahrain | 2013-04-01 | 2019-10-23 | |
| PACAP38´s (Pituitary Adenylate Cyclase-Activating Polypeptide) Headache Inducing Characteristics and Effects on the Cerebral Blood Flow PACAP38 - Migraine Without Aura | Not applicable | Completed | Danish Headache Center | 12 | 2006-11-01 | 2008-05-30 |
Migraine Disorders (5) · Migraine without Aura (5) · Headache (4) · Osteoarthritis (2) · Pain (2) · Epilepsy (1) · Migraine with Aura (1) · Osteoarthritis, Knee (1) · Post-Traumatic Headache (1)
Danish Headache Center (9) · Aliaa Babekir Ahmed Mohamed (1) · Amgen (1) · Izmir Democracy University (1) · KTO Karatay University (1) · King Hamad University Hospital, Bahrain (1) · Song Guo (1)
Denmark (9) · Turkey (Türkiye) (2) · Bahrain (1) · Belgium (1) · Egypt (1) · Netherlands (1) · United States (1)
Ahsan J Butt, FRCS(T&O) (1) · Fares Uddin, MBBCh (1) · Fathima M Nasmy, MBBCh (1) · Hakan Ashina, MD (1) · Hassan Ab Ghany, Prof (1) · Henrik Schytz, MD (1) · Khaleefa ElMusharraf, MBBS,FRSPH (1) · Messoud Ashina, MD,PhD,DMSc (1) · Messoud Ashina, Professor (1) · Tania Kumar, MBBCh (1)