18 completed, 9 recruiting, 5 terminated, 4 unknown. 25 Not applicable, 8 Phase 3, 5 Phase 2, 2 Phase 1, 1 Phase 4.
Follow Photophobia: new trials by email Literature Review of Photophobia trials Research Report on Photophobia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Examining Lithium's Mechanism in Bipolar Disorder Lithium carbonate (Priadel), Controlled light exposure - Healthy, Bipolar | Not applicable | Not yet recruiting | Northumbria University | 45 | 2026-08-01 | 2026-08-06 |
| Comparison Between Spectacles and Contact Lenses Biomedics55 Premier contact lenses, and Altius Tinted Contact Lenses - Photophobia | Not applicable | Not yet recruiting | University of Oklahoma | 200 | 2026-07-01 | 2026-05-05 |
| Use of Tinted Contact Lenses for Concussion-Related Light Sensitivity Narrow band (tinted) contact lenses, broad band (clear) contact lenses - Concussion, Mild, Photophobia | Not applicable | Recruiting | University of Alabama at Birmingham | 60 | 2026-05-08 | 2026-06-11 |
| Light Exposure, Migraine Outcomes, and Sleep Quality Ambient Lighting Condition - Migraine Headache, Sleep | Not applicable | Recruiting | Arizona State University | 20 | 2026-03-24 | 2026-04-28 |
| Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli Visual Adaptation, Assessments and Questionnaires, Functional Magnetic Resonance Imaging (fMRI) - Visual Snow Syndrome, Migraine | Not applicable | Recruiting | University of Minnesota | 100 | 2025-04-11 | 2026-01-14 |
| Impact Of Everyday Light Exposure Patterns On Health 10-day ambulatory assessment in everyday life combined with two laboratory office days - Healthy Male and Female Subjects, Healthy Elderly | Not applicable | Completed | RWTH Aachen University | 62 | 2024-11-18 | 2025-07-10 |
| Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury Micro Current Neurofeedback Device using Low-Frequency Pulse-Based Transcranial Electrical Stimulation - Mild Traumatic Brain Injury, Photophobia | Not applicable | Recruiting | VA Office of Research and Development | 36 | 2024-01-01 | 2025-12-16 |
| Migraine Headache Mitigation Utilizing Avulux Avulux Lenses, Placebo Lenses - Migraine, Headache | Not applicable | Unknown | Kaiser Permanente | 40 | 2023-12-13 | 2023-11-28 |
| Eye Movement Behaviour and Pupil Size in Natural Outdoor and Indoor Scenes Indoor vs. outdoor scenes - Light Sensitivity | Not applicable | Unknown | Technical University of Munich | 24 | 2023-07-01 | 2023-08-02 |
| Improving Glare and Visual Comfort for Patients With Visual Impairment Acuvue Oasys with Transitions - Photophobia, Visual Impairment | Not applicable | Withdrawn | Nova Southeastern University | 2023-05-01 | 2025-06-19 | |
| Safety and Tolerability Study of Daily Dosing Rimegepant in Episodic Migraine Prevention Rimegepant - Migraine, Episodic Migraine | Phase 4 | Completed | Pfizer | 441 | 2022-03-15 | 2025-09-03 |
| Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects Rimegepant, Placebo - Migraine | Phase 3 | Recruiting | Pfizer | 640 | 2022-02-28 | 2026-10-14 |
| Performance and Tolerability of the Medical Device LACRIACT LACRIACT - Dry Eye, Contact Lens Acute Red Eye | Not applicable | Completed | Laboratórios Baldacci S.A | 20 | 2021-09-09 | 2023-12-14 |
| Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine Rimegepant (PF-07899801) - Acute Treatment of Migraine | Phase 3 | Recruiting | Pfizer | 600 | 2021-04-28 | 2026-09-24 |
| A Study to Evaluate the Efficacy and Safety of Oral Zavegepant in Migraine Prevention BHV-3500 (zavegepant), Placebo - Migraine | Phase 2 / Phase 3 | Terminated | Pfizer | 1753 | 2021-03-26 | 2025-03-27 |
| Randomized Study in Children and Adolescents With Migraine: Acute Treatment Rimegepant/BHV3000, Matching placebo - Pediatric Migraine | Phase 3 | Recruiting | Pfizer | 2100 | 2021-01-15 | 2026-09-24 |
| Randomized Trial in Adult Participants With Acute Migraines Zavegepant, Placebo - Migraine | Phase 3 | Completed | Pfizer | 1978 | 2020-10-27 | 2023-04-24 |
| Light at Night Study Light intensity, ~30 lux, Baseline light intensity, <1 lux - Bipolar Disorder, Light Sensitivity | Not applicable | Terminated | University of Michigan | 2 | 2020-10-15 | 2021-08-12 |
| Validation of a Questionnaire for Allodynia in Migraine. Questionnaire - Migraine | Unknown | University Hospital, Clermont-Ferrand | 180 | 2020-10-01 | 2020-10-08 | |
| Mindfulness Based Cognitive Therapy Modified for Visual Symptoms (MBCT-vision) Mindfulness Based Cognitive Therapy - Visual Snow Syndrome, Trailing Phenomenon | Not applicable | Completed | Guy's and St Thomas' NHS Foundation Trust | 22 | 2020-01-09 | 2023-09-18 |
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Migraine Disorders (20) · Hyperacusis (11) · Nausea (8) · Headache (5) · Brain Concussion (3) · Brain Injuries, Traumatic (3) · Dry Eye Syndromes (2) · Epilepsy (2) · Pain (2) · visual snow syndrome (2) · Agoraphobia (1) · Alkaptonuria (1) · Aniridia (1) · Anxiety Disorders (1)
Eye Diseases (42) · Nervous System Diseases (42) · Neurologic Manifestations (42) · Pathological Conditions, Signs and Symptoms (42) · Sensation Disorders (42) · Signs and Symptoms (42) · Vision Disorders (41) · Brain Diseases (25) · Central Nervous System Diseases (25) · Headache Disorders, Primary (20) · Headache Disorders (19) · Ear Diseases (11) · Hearing Disorders (11) · Otorhinolaryngologic Diseases (11) · Signs and Symptoms, Digestive (8)
rimegepant sulfate (5) · Surveys and Questionnaires (2) · Atropine (1) · Contact Lenses (1) · Diclofenac (1) · Ketoprofen (1) · Lithium Carbonate (1) · Magnetic Resonance Imaging (1) · Mindfulness-Based Cognitive Therapy (1) · erenumab (1) · nitisinone (1)
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Bradley Katz, MD (2) · Abby Metzler, M.D. (1) · Andrew Hartwick, OD, PhD (1) · Andrew Melson, MD (1) · Bradley J Katz, MD (1) · Candice I Turner, OD (1) · Carrie E Robertson, M.D. (1) · Crist J. Frangakis, Ph.D. (1) · Erika M. Espino-Torres, MD (1) · Francesca C Fortenbaugh, PhD (1) · Gennaro Crugliano, MD, Prof (1) · Helen Burgess, PhD (1)
PMID 18812117, PMID 26603402, PMID 27373394, PMID 27464575, PMID 29515428, PMID 30041739, PMID 31486844, PMID 32429847, PMID 33038155, PMID 35948966, PMID 36804093, PMID 36864830, PMID 37539829, PMID 37768273, PMID 37967050, PMID 38717424, PMID 41235617, PMID 41366286, PMID 42332292, PMID 42645743
2019 (1), R01EY029595 (1), R01EY036005 (1)