11 recruiting, 5 completed, 5 not yet recruiting, 3 enrolling by invitation. 26 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 26 | Recruiting 11, Completed 5, Not yet recruiting 5, Enrolling by invitation 3, Active not recruiting 2 |
Follow MASLD: new trials by email Literature Review of MASLD trials Research Report on MASLD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effects of 5-methyltetrahydrofolate Supplementation in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease 5-methyltetrahydrofolate (5-MTHF), placebo group - Nonalcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD) | Not applicable | Not yet recruiting | Tabriz University of Medical Sciences | 44 | 2026-09-30 | 2026-07-31 |
| A Study of Electronic Clinical Decision Support Tools for Steatotic Liver Disease eMPOWER Decision Aid - MASLD | Not applicable | Recruiting | Vanderbilt University Medical Center | 7200 | 2026-07-20 | 2026-07-21 |
| Improving Liver Fibrosis Diagnosis in Primary Care Using FibroX AI FibroX, Usual Care - MASLD, Fibrosis of Liver | Not applicable | Not yet recruiting | Yale University | 40 | 2026-06-15 | 2025-12-26 |
| Effects of Peanut Consumption on Adults With Metabolic Associated Fatty Liver Disease Peanut consumption - MASLD, Fatty Liver | Not applicable | Recruiting | Henry Ford Health System | 125 | 2026-06-09 | 2026-08-06 |
| Safety and Efficacy of Finerenone in Metabolic Dysfunction Associated Steatotic Liver Disease(MASLD/NAFLD) Related Cirrhosis Patients With Ascites in Prevention of Chronic Kidney Disease. Finerenone, Spironolactone, Standard Medical Treatment - MASLD, Chronic Kidney Diseases | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 160 | 2026-04-15 | 2026-05-13 |
| Accumulation of Lipid Droplets as an Underlying Cause of the Progression of Fatty Liver Disease to Liver Cancer Comprehensive Genomic and Transcriptomic Profiling, Patient-Derived Human Liver Organoid (HLO) Development, AI-Driven Digital Pathology (HistoIndex) - HCC, MASLD | Not applicable | Active not recruiting | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 35500 | 2026-01-29 | 2026-08-20 |
| Chrononutrition/ Chronotoxicity Intervention in People With Metabolic-associated Steatotic Liver Disease. Diet-Time-restricted eating (TRE), Lifestyle Management - MASLD, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease | Not applicable | Not yet recruiting | Cyprus University of Technology | 150 | 2026-01-05 | 2025-11-19 |
| Hepatic Gene Response to Intravenous Glucose in Obese Patients With and Without MASLD Undergoing Bariatric Surgery [6,6-D2]-labeled glucose (intravenous), Saline (0.9% sodium chloride infusion) - MASLD | Not applicable | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 40 | 2025-11-12 | 2026-01-08 |
| DEFINITION OF THE GENOMIC LANDSCAPE OF MASLD genetic and somatic variants involved in its progression toward advanced fibrosis and hepatocellular carcinoma - Cirrhosis, MASLD | Not applicable | Recruiting | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 2880 | 2025-09-01 | 2025-11-25 |
| Evaluation of a New Ultrasound System for the Non-invasive Assessment of Liver Steatosis in MASLD/MASH Patients Liver ultrasound - Metabolic Syndrome X, Fatty Liver | Not applicable | Recruiting | E-Scopics | 120 | 2025-07-24 | 2025-08-15 |
| Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial ESG + lifestyle modification, Lifestyle modification - Obesity, Liver Diseases | Not applicable | Recruiting | Pichamol Jirapinyo, MD, MPH | 132 | 2025-06-24 | 2026-06-25 |
| The Impact of Pectin Supplementation on Systematic Inflammation Pathway, Gut Microbiome, and Metabolic Health in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Pectin, Cocoa Powder, Magnetic Resonance Imaging with Contrast - Nonalcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD) | Not applicable | Recruiting | University of Nottingham | 45 | 2025-06-10 | 2026-07-29 |
| Hepatic Elastography-Enhanced Lifestyle Modification in MASLD Regular monitoring with transient elastography - Transient Elastography, MASLD | Not applicable | Enrolling by invitation | Mahidol University | 92 | 2025-05-12 | 2025-05-13 |
| Effects of a Healthy Nordic Diet on Atherosclerosis in Patients with Coronary Heart Disease Healthy Nordic Diet, Usual Care - Coronary Disease, Coronary Arteriosclerosis | Not applicable | Recruiting | Uppsala University | 150 | 2025-03-20 | 2025-03-06 |
| Effect of Ancestry Supplementation in Subjects With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Ancestry, Placebo - MASLD | Not applicable | Enrolling by invitation | University of Guadalajara | 60 | 2025-02-26 | 2026-05-18 |
| Ultrasound-Based Estimation of Hepatic Steatosis in Pediatric MASLD Ultrasound and MRI - MASLD, Pediatric | Not applicable | Completed | Jae Won Choi | 50 | 2024-12-31 | 2025-12-04 |
| High Fructose Diet, the Gut Microbiome, and Metabolic Health Fructose, glucose - MASLD, Type 2 Diabetes | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 30 | 2024-10-08 | 2025-12-17 |
| The Efficacy of Pedometer-motivated Physical Activity for the Management of Patients With MASLD. Encourage using pedometer - Daily Step Count, MASLD | Not applicable | Enrolling by invitation | Mahidol University | 86 | 2024-08-01 | 2025-05-15 |
| Acceptability and Feasibility of a New Approach to Engage Patients With Steatotic Liver Disease in Physical Activity Telehealth coaching for liver disease - Liver Steatosis, MASH | Not applicable | Not yet recruiting | Hopital Montfort | 12 | 2024-08-01 | 2024-06-06 |
| Acquisition of Cardiac Function Parameters in MRI and Echocardiography in Patients With Ethyltoxic Liver Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt (TIPSS) Placement Cardiac MRI, Blood samples, Echocardiography - MASLD, Liver Cirrhosis, Alcoholic | Not applicable | Recruiting | Stephanie Gräger | 80 | 2024-04-19 | 2026-08-04 |
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Non-alcoholic Fatty Liver Disease (11) · Fatty Liver (7) · Diabetes Mellitus, Type 2 (3) · Fibrosis (3) · Insulin Resistance (3) · Metabolic Syndrome (3) · Obesity (3) · Cardiovascular Diseases (2) · Liver Cirrhosis (2) · Motor Activity (2) · Atherosclerosis (1) · Coronary Artery Disease (1) · Coronary Disease (1) · Diabetes Mellitus (1) · Digestive System Diseases (1)
Digestive System Diseases (17) · Liver Diseases (16) · Pathological Conditions, Signs and Symptoms (10) · Fatty Liver (8) · Pathologic Processes (8) · Nutritional and Metabolic Diseases (7) · Glucose Metabolism Disorders (6) · Metabolic Diseases (5) · Hyperinsulinism (4) · Behavior (3) · Body Weight (3) · Endocrine System Diseases (3) · Nutrition Disorders (3) · Overnutrition (3) · Overweight (3)
Diet, Mediterranean (2) · Magnetic Resonance Imaging (2) · 5-methyltetrahydrofolate (1) · Blood Specimen Collection (1) · Chocolate (1) · Cognitive Behavioral Therapy (1) · Echocardiography (1) · Exercise (1) · Fructose (1) · Glucose (1) · Growth and Development (1) · Nutritional Support (1) · Pectins (1) · Sodium Chloride (1) · Spironolactone (1)
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (2) · Mahidol University (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Cyprus University of Technology (1) · E-Scopics (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · Henry Ford Health System (1) · Hopital Montfort (1) · Icahn School of Medicine at Mount Sinai (1) · Institute of Liver and Biliary Sciences, India (1) · Jae Won Choi (1) · Pichamol Jirapinyo, MD, MPH (1) · Stephanie Gräger (1) · Tabriz University of Medical Sciences (1) · University of Alabama at Birmingham (1)
United States (6) · Italy (4) · France (2) · Thailand (2) · Cyprus (1) · Germany (1) · India (1) · Iran (1) · Mexico (1) · Netherlands (1) · South Korea (1) · Spain (1) · Sweden (1) · United Kingdom (1)
Alexander Zipprich (1) · Ashley Spann, MD, MSACI (1) · Bahram Pourghassem Gargari (1) · Celine Fresne, MD (1) · Claude Cohen-Bacrie (1) · Guruprasad P Aithal, Professor (1) · Hashem B. El-Serag, MD MPH (1) · Jane Grove, Associate Professor (1) · Jerome Boursier, MD, PhD (1) · Kyle D Wood, MD (1) · Max Nieuwdorp, Prof. Dr. (1)
PMID 12941756, PMID 15940625, PMID 17327354, PMID 18820647, PMID 18972405, PMID 19444870, PMID 20101745, PMID 21206486, PMID 21618575, PMID 21898504, PMID 22958053, PMID 25007047, PMID 25040896, PMID 25145475, PMID 25580206, PMID 25715361, PMID 26378644, PMID 26610348, PMID 26707365, PMID 27038645, PMID 27836992, PMID 27917585, PMID 27936024, PMID 28039099, PMID 28545937, PMID 28585193, PMID 28879026, PMID 29042429, PMID 29296097, PMID 29610219, PMID 29886156, PMID 29984130, PMID 31949537, PMID 32207804, PMID 32522147, PMID 32683103, PMID 32882428, PMID 32967678, PMID 33259835, PMID 33898961, PMID 34166721, PMID 34987607, PMID 36719059, PMID 36727674, PMID 37676198, PMID 38143613, PMID 38228377, PMID 38615137, PMID 38727678, PMID 39389571
R01DK137968 (1), R03DK139235 (1)