20 recruiting, 10 not yet recruiting, 5 completed, 5 enrolling by invitation. 26 Not applicable, 3 Phase 2, 2 Phase 3, 1 Early Phase 1, 1 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) ALN-CIDEB, Placebo - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD | Phase 3 | Not yet recruiting | Regeneron Pharmaceuticals | 1500 | 2026-11-06 | 2026-10-02 |
| The Effects of 5-methyltetrahydrofolate Supplementation in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease 5-methyltetrahydrofolate (5-MTHF), placebo group - Nonalcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD) | Not applicable | Not yet recruiting | Tabriz University of Medical Sciences | 44 | 2026-09-30 | 2026-07-31 |
| FIB-4 Cut-Offs for Liver Fibrosis in Obese Endocrinology Patients MASLD | Not yet recruiting | Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis | 400 | 2026-09-01 | 2026-06-23 | |
| Study of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Adults With Type 1 Diabetes MASLD, Type 1 Diabetes | Not yet recruiting | Sohag University | 250 | 2026-08-22 | 2026-08-06 | |
| RESET-INSPIRE Study: Insulin Sensitivity & Population Intervention With Real-time Evaluation Using CGM Diabete Mellitus, MASLD | Recruiting | National University Health System, Singapore | 270 | 2026-07-27 | 2026-10-06 | |
| A Study of Electronic Clinical Decision Support Tools for Steatotic Liver Disease eMPOWER Decision Aid - MASLD | Not applicable | Recruiting | Vanderbilt University Medical Center | 7200 | 2026-07-20 | 2026-07-21 |
| Improving Liver Fibrosis Diagnosis in Primary Care Using FibroX AI FibroX, Usual Care - MASLD, Fibrosis of Liver | Not applicable | Not yet recruiting | Yale University | 40 | 2026-06-15 | 2025-12-26 |
| Effects of Peanut Consumption on Adults With Metabolic Associated Fatty Liver Disease Peanut consumption - MASLD, Fatty Liver | Not applicable | Recruiting | Henry Ford Health System | 125 | 2026-06-09 | 2026-08-06 |
| Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV MASLD, HIV (Human Immunodeficiency Virus) | Not yet recruiting | Yinzhong Shen | 120 | 2026-06-01 | 2026-06-11 | |
| Integrated Ultrasound-Derived Fat Fraction and 2D/4D HeartAI for Cardiovascular Risk Management in Patients With MASLD MASLD, Cardiovascular (CV) Risk | Not yet recruiting | First Affiliated Hospital, Sun Yat-Sen University | 700 | 2026-06-01 | 2026-04-22 | |
| Safety and Efficacy of Finerenone in Metabolic Dysfunction Associated Steatotic Liver Disease(MASLD/NAFLD) Related Cirrhosis Patients With Ascites in Prevention of Chronic Kidney Disease. Finerenone, Spironolactone, Standard Medical Treatment - MASLD, Chronic Kidney Diseases | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 160 | 2026-04-15 | 2026-05-13 |
| Accurate Point of Care Liver Disease Diagnostics (Phase 2) LiverScope® exam, MR exam, Blood draw - MASLD, MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) | Recruiting | University of California, San Diego | 26 | 2026-04-08 | 2026-04-09 | |
| Accumulation of Lipid Droplets as an Underlying Cause of the Progression of Fatty Liver Disease to Liver Cancer Comprehensive Genomic and Transcriptomic Profiling, Patient-Derived Human Liver Organoid (HLO) Development, AI-Driven Digital Pathology (HistoIndex) - HCC, MASLD | Not applicable | Active not recruiting | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 35500 | 2026-01-29 | 2026-08-20 |
| Chrononutrition/ Chronotoxicity Intervention in People With Metabolic-associated Steatotic Liver Disease. Diet-Time-restricted eating (TRE), Lifestyle Management - MASLD, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease | Not applicable | Not yet recruiting | Cyprus University of Technology | 150 | 2026-01-05 | 2025-11-19 |
| Hepatic Gene Response to Intravenous Glucose in Obese Patients With and Without MASLD Undergoing Bariatric Surgery [6,6-D2]-labeled glucose (intravenous), Saline (0.9% sodium chloride infusion) - MASLD | Not applicable | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 40 | 2025-11-12 | 2026-01-08 |
| Assessment of Non-Invasive Testing in Major Liver-Related Outcomes Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD | Enrolling by invitation | HRI-MAIL-NIT | 1689 | 2025-10-25 | 2026-03-27 | |
| Endoscopic Ultrasound Shear Wave Elastography Study Endoscopic Ultrasound Shear Wave Elastography (EUS) and Attenuation Imaging, FibroScan, Liver biopsy - MASLD, MASH | Recruiting | Olympus Corporation of the Americas | 300 | 2025-09-03 | 2025-09-15 | |
| DEFINITION OF THE GENOMIC LANDSCAPE OF MASLD genetic and somatic variants involved in its progression toward advanced fibrosis and hepatocellular carcinoma - Cirrhosis, MASLD | Not applicable | Recruiting | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 2880 | 2025-09-01 | 2025-11-25 |
| Evaluation of a New Ultrasound System for the Non-invasive Assessment of Liver Steatosis in MASLD/MASH Patients Liver ultrasound - Metabolic Syndrome X, Fatty Liver | Not applicable | Recruiting | E-Scopics | 120 | 2025-07-24 | 2025-08-15 |
| Effect of Tirzepatide on Markers of MASLD in Patients With Obesity Tirzepatide - MASLD, Obesity | Early Phase 1 | Recruiting | University of New Mexico | 8 | 2025-06-30 | 2026-09-04 |
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Non-alcoholic Fatty Liver Disease (18) · Fatty Liver (13) · Obesity (9) · Liver Cirrhosis (8) · Diabetes Mellitus, Type 2 (6) · Insulin Resistance (5) · Metabolic Syndrome (4) · Diabetes Mellitus (3) · Fibrosis (3) · Cardiovascular Diseases (2) · Hypertension (2) · Intermittent Fasting (2) · Liver Diseases (2) · Motor Activity (2) · Acquired Immunodeficiency Syndrome (1)
Digestive System Diseases (29) · Liver Diseases (27) · Pathological Conditions, Signs and Symptoms (19) · Nutritional and Metabolic Diseases (15) · Pathologic Processes (14) · Fatty Liver (13) · Glucose Metabolism Disorders (12) · Metabolic Diseases (11) · Body Weight (9) · Nutrition Disorders (9) · Overnutrition (9) · Signs and Symptoms (9) · Endocrine System Diseases (8) · Fibrosis (8) · Overweight (8)
Blood Specimen Collection (3) · Diet, Mediterranean (3) · Magnetic Resonance Imaging (2) · Surveys and Questionnaires (2) · 5-methyltetrahydrofolate (1) · Anastomosis, Roux-en-Y (1) · Bariatric Surgery (1) · Biliopancreatic Diversion (1) · Body Weights and Measures (1) · Bupropion (1) · Chocolate (1) · Cognitive Behavioral Therapy (1) · Diet Therapy (1) · Digoxin (1) · Echocardiography (1)
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (2) · Mahidol University (2) · University of California, San Diego (2) · Yale University (2) · Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis (1) · Beijing Tsinghua Chang Gung Hospital (1) · Carmen Dietvorst (1) · Cyprus University of Technology (1) · E-Scopics (1) · First Affiliated Hospital, Sun Yat-Sen University (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · HRI-MAIL-NIT (1) · Henry Ford Health System (1) · Hopital Montfort (1)
United States (12) · Italy (5) · China (4) · Netherlands (4) · France (3) · Germany (2) · Spain (2) · Thailand (2) · United Kingdom (2) · Bahrain (1) · Belgium (1) · Cyprus (1) · Czechia (1) · Egypt (1) · Greece (1)
Claude B Sirlin, MD (2) · Alexander Zipprich (1) · Ashley Spann, MD, MSACI (1) · Bahram Pourghassem Gargari (1) · Bubu A Banini, MD, PhD (1) · Celine Fresne, MD (1) · Claude Cohen-Bacrie (1) · Diederick E. Grobbee, MD/PhD/FESC (1) · Eliseo Castillo (1) · Guruprasad P Aithal, Professor (1) · Hashem B. El-Serag, MD MPH (1) · Jane Grove, Associate Professor (1)
PMID 12941756, PMID 15940625, PMID 17327354, PMID 18820647, PMID 18972405, PMID 19444870, PMID 20101745, PMID 21206486, PMID 21618575, PMID 21898504, PMID 22958053, PMID 25007047, PMID 25040896, PMID 25145475, PMID 25580206, PMID 25715361, PMID 26378644, PMID 26610348, PMID 26707365, PMID 27038645, PMID 27836992, PMID 27917585, PMID 27936024, PMID 28039099, PMID 28545937, PMID 28585193, PMID 28879026, PMID 29042429, PMID 29296097, PMID 29610219, PMID 29886156, PMID 29984130, PMID 30704819, PMID 31949537, PMID 32207804, PMID 32522147, PMID 32683103, PMID 32882428, PMID 32967678, PMID 33259835, PMID 33898961, PMID 34166721, PMID 34987607, PMID 35584814, PMID 36719059, PMID 36727674, PMID 37676198, PMID 38143613, PMID 38228377, PMID 38615137
R01DK134624 (1), R01DK135951 (1), R01DK137968 (1), R03DK139235 (1), R44DK135225 (1)