3 not yet recruiting, 2 recruiting, 1 completed, 1 enrolling by invitation. 2 Not applicable, 2 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 2 | Enrolling by invitation 1, Not yet recruiting 1 |
| Phase 1 | 2 | Not yet recruiting 2 |
| Phase 2 | 1 | Completed 1 |
Follow Major Depression Severe: new trials by email Literature Review of Major Depression Severe trials Research Report on Major Depression Severe
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Shortened LSD Intervention for Major Depressive Disorder LSD, Risperidone - Major Depression Moderate, Major Depression Severe | Phase 1 | Not yet recruiting | Johns Hopkins University | 10 | 2026-10-01 | 2026-09-22 |
| Oral and Sublingual Ketamine 75 mg of oral ketamine, Sublingual ketamine 75 mg - Major Depression Severe | Phase 1 | Not yet recruiting | Western University, Canada | 10 | 2026-10-01 | 2026-07-06 |
| EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT Electroconvulsive Therapy - Major Depression Moderate, Major Depression Severe | Recruiting | Istanbul University - Cerrahpasa | 62 | 2026-01-01 | 2026-08-05 | |
| EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT Electroconvulsive Therapy - Major Depression Moderate, Major Depression Severe | Recruiting | Istanbul University - Cerrahpasa | 62 | 2025-12-01 | 2026-07-31 | |
| Virtual Reality-Augmented At-Home tDCS for Major Depression tDCS, VR-based relaxation therapy - Major Depression Moderate, Major Depression Severe | Not applicable | Enrolling by invitation | Technical University of Munich | 30 | 2025-07-15 | 2025-08-28 |
| Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling LCHF Ketogenic Diet, Diet-as-Usual (DAU) - Schizophrenia, Schizophrenia and Related Disorders | Not applicable | Not yet recruiting | Stanford University | 120 | 2025-07-01 | 2025-05-16 |
| Ayahuasca and Esketamine for Major Depression Ayahuasca, Esketamine - Major Depression Severe | Phase 2 | Completed | University of Sao Paulo | 22 | 2022-10-30 | 2025-12-29 |
| MRS and Medication Response: A Pilot Study Major Depressive Disorder, Major Depressive Episode | Terminated | Stanford University | 3 | 2013-08-06 | 2021-08-19 |
Depressive Disorder, Major (6) · Bipolar Disorder (2) · Depression (2) · Depressive Disorder, Treatment-Resistant (2) · Bipolar and Related Disorders (1) · Catatonia (1) · Ketosis (1) · Mental Disorders (1) · Metabolic Diseases (1) · Metabolic Syndrome (1) · Recurrence (1) · Schizophrenia (1)
Depressive Disorder (6) · Mood Disorders (6) · Mental Disorders (5) · Behavior (3) · Behavioral Symptoms (3) · Pathological Conditions, Signs and Symptoms (2) · Acid-Base Imbalance (1) · Acidosis (1) · Bipolar and Related Disorders (1) · Disease Attributes (1) · Glucose Metabolism Disorders (1) · Hyperinsulinism (1) · Insulin Resistance (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1)
Ketamine (2) · Esketamine (1) · Lysergic Acid Diethylamide (1) · Risperidone (1) · Transcranial Direct Current Stimulation (1)
Istanbul University - Cerrahpasa (2) · Stanford University (2) · Johns Hopkins University (1) · Technical University of Munich (1) · University of Sao Paulo (1) · Western University, Canada (1)
United States (3) · Turkey (Türkiye) (2) · Brazil (1) · Germany (1)
Michael Snyder, PhD (1) · Sandeep Nayak, MD (1) · Shebani Sethi, MD, ABOM (1)