23 completed. 23 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 23 | Completed 23 |
| Phase 2 | 7 | Completed 7 |
Follow Liver Failure: new trials by email Literature Review of Liver Failure trials Research Report on Liver Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Implications of Fecal Microbiota Transplantation in Modulating the Effects of Liver Cirrhosis Fecal microbiota transplantation - Liver Cirrhosis | Phase 3 | Completed | Cristian Ichim | 19 | 2024-08-05 | 2026-03-27 |
| Efficacy and Safety of Nifuroxazide in the Treatment of Hepatic Encephalopathy in Egyptian Patients With Liver Cirrhosis Nifuroxazide, Lactulose, Rifaximin 550Mg Tab - Hepatic Encephalopathy | Phase 3 | Completed | Cairo University | 80 | 2023-03-12 | 2025-09-02 |
| Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis Allopurinol 300 MG, Atorvastatin 20mg, Placebo - Cirrhosis, Hepatic Encephalopathy | Phase 2 / Phase 3 | Completed | Tanta University | 150 | 2022-11-15 | 2026-08-11 |
| Evaluation of Rifaximin SSD for Delaying Encephalopathy Decompensation in Patients With Cirrhosis Rifaximin SSD, Placebo - Hepatic Encephalopathy | Phase 3 | Completed | Bausch Health Americas, Inc. | 517 | 2022-08-03 | 2026-10-28 |
| Growth Hormone in Decompensated Liver Cirrhosis Growth Hormone - Liver Cirrhosis, Fibrosis | Phase 2 / Phase 3 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 96 | 2022-02-01 | 2025-12-16 |
| A Trial to Improve Quality of Life in People With Cirrhosis Lactulose - Cirrhosis | Phase 2 / Phase 3 | Completed | University of Michigan | 56 | 2021-11-10 | 2023-11-21 |
| 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF 13C-Methacetin - Acute Liver Failure | Phase 2 / Phase 3 | Completed | University of Texas Southwestern Medical Center | 76 | 2016-06-10 | 2020-12-22 |
| Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation Dual hypothermic oxygenated perfusion, Liver Assist®, Perfusion fluid - Liver Failure, End Stage Liver Disease | Phase 3 | Completed | Robert J. Porte | 157 | 2016-01-01 | 2021-01-12 |
| Fast-track LiveR: Study for the Early Identification of Low-risk Patients After Partial Liver Resection by the LiMAx-test 13-C-Methacetin - Liver Failure | Phase 3 | Completed | Humedics GmbH | 149 | 2013-01-01 | 2018-10-25 |
| Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure Granulocyte Colony-stimulating Factor (G-CSF) and Erythropoetin (EPO), Placebo - Acute on Chronic Hepatic Failure | Phase 3 | Completed | Institute of Liver and Biliary Sciences, India | 55 | 2011-07-01 | 2016-12-06 |
| Effect of Tolvaptan on Cognitive Function in Cirrhosis Tolvaptan - Cirrhosis, Hepatic Encephalopathy | Phase 3 | Completed | Hunter Holmes Mcguire Veteran Affairs Medical Center | 25 | 2011-04-01 | 2014-02-07 |
| Donor Simvastatin Treatment in Organ Transplantation Simvastatin 80mg, Control Rx - Heart Failure, Respiratory Failure | Phase 2 / Phase 3 | Completed | Helsinki University Central Hospital | 84 | 2010-06-01 | 2017-09-19 |
| Secondary Prophylaxis of Hepatic Encephalopathy With a Probiotic Preparation VSL#3, Placebo - Hepatic Encephalopathy | Phase 2 / Phase 3 | Completed | CD Pharma India Pvt. Ltd. | 130 | 2010-04-01 | 2013-12-30 |
| Effect of Probiotics in Treatment of Minimal Hepatic Encephalopathy (MHE) and Health Related Quality of Life VSL#3, Lactulose - Chronic Liver Disease, Hepatic Encephalopathy | Phase 2 / Phase 3 | Completed | CD Pharma India Pvt. Ltd. | 120 | 2009-10-01 | 2013-06-04 |
| CNI-free de Novo Protocol in Patients Undergoing Liver Transplantation With Renal Impairment anti-CD 25 mAb, Sirolimus, MMF - End Stage Liver Disease, Impaired Renal Function | Phase 3 | Completed | University of Regensburg | 27 | 2008-12-01 | 2014-12-16 |
| Improving Clinician Communication Skills (ICCS) Training Program Intervention - Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD) | Phase 3 | Completed | University of Washington | 6086 | 2007-04-01 | 2014-09-16 |
| Safety and Tolerability Study of Rifaximin in Participants With a History of Hepatic Encephalopathy Rifaximin - Hepatic Encephalopathy | Phase 3 | Completed | Bausch Health Americas, Inc. | 322 | 2007-03-07 | 2019-08-14 |
| A 6-month Efficacy, Safety, and Tolerability Study of Rifaximin In Preventing Hepatic Encephalopathy Rifaximin, Placebo - Hepatic Encephalopathy | Phase 3 | Completed | Bausch Health Americas, Inc. | 299 | 2005-12-19 | 2019-09-18 |
| The MARS® Albumin Dialysis System in Patients With Fulminant and Subfulminant Hepatic Failure Molecular Adsorbent Recirculating System (MARS®) - Hepatitis | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 110 | 2004-08-01 | 2011-02-17 |
| Clinical Trial of Pentoxifylline in Patient With Cirrhosis pentoxifylline, PLACEBO - Cirrhosis, Liver Failure | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 342 | 2004-08-01 | 2008-01-17 |
Showing 20 of 23. Sign in to see all of them.
Hepatic Encephalopathy (13) · Fibrosis (7) · End Stage Liver Disease (4) · Liver Failure, Acute (4) · Liver Cirrhosis (3) · Heart Failure (2) · Renal Insufficiency (2) · Acute-On-Chronic Liver Failure (1) · Ascites (1) · Biliary Tract Diseases (1) · Digestive System Diseases (1) · Gastrointestinal Diseases (1) · Hepatitis (1) · Hypertension, Portal (1)
Hepatic Insufficiency (23) · Digestive System Diseases (22) · Liver Diseases (22) · Nervous System Diseases (14) · Brain Diseases (13) · Brain Diseases, Metabolic (13) · Central Nervous System Diseases (13) · Metabolic Diseases (13) · Nutritional and Metabolic Diseases (13) · Pathologic Processes (11) · Pathological Conditions, Signs and Symptoms (11) · Cardiovascular Diseases (3) · Disease Attributes (2) · Female Urogenital Diseases (2)
Lactulose (3) · Rifaximin (3) · Acetylcysteine (2) · Allopurinol (1) · Atorvastatin (1) · Basiliximab (1) · Colonoscopy (1) · Fecal Microbiota Transplantation (1) · Glucose (1) · Glutathione (1) · Granulocyte Colony-Stimulating Factor (1) · Growth Hormone (1) · Mycophenolic Acid (1) · Pentoxifylline (1) · Probiotics (1)
Bausch Health Americas, Inc. (3) · Assistance Publique - Hôpitaux de Paris (2) · CD Pharma India Pvt. Ltd. (2) · Aga Khan University (1) · Cairo University (1) · Cristian Ichim (1) · Helsinki University Central Hospital (1) · Humedics GmbH (1) · Hunter Holmes Mcguire Veteran Affairs Medical Center (1) · Institute of Liver and Biliary Sciences, India (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · Robert J. Porte (1) · Tanta University (1) · University of Michigan (1)
United States (8) · India (5) · Canada (3) · France (3) · Germany (3) · United Kingdom (3) · Belgium (2) · Egypt (2) · Australia (1) · Bulgaria (1) · Finland (1) · Hungary (1) · Italy (1) · Mongolia (1) · Netherlands (1)
Lindsey Mathew (2) · Adrian Boicean, Prof. Dr. (1) · Andreas A Schnitzbauer, MD (1) · Elliot Tapper, MD (1) · Hans J Schlitt, MD (1) · J. Randall Curtis, MD, MPH (1) · Jasmohan S Bajaj, MD (1) · Karl B Lemstrom, MD, PhD (1) · Marcus N Scherer, MD (1) · Martin Stockmann, PD Dr. med. (1) · Mennat Allah S. Emam (1) · Radha K Dhiman, MD,DM,MNAMS (1) · Robert H Squires, M.D. (1)
PMID 37183883, PMID 37467180, PMID 19524577, PMID 20102716, PMID 20335583, PMID 20840760, PMID 21848797, PMID 24126646, PMID 24302090, PMID 24365449, PMID 24649963, PMID 25450083, PMID 26018348, PMID 30263981, PMID 30283499, PMID 30866837, PMID 31325468, PMID 31352795, PMID 31420387, PMID 31421008, PMID 33626248, PMID 34712928, PMID 39853733, PMID 40943741, PMID 41082480, PMID 41464526
U01DK058369 (2), R01DK058369 (1), R01NR009987 (1), R03DK052827 (1), U01DK072146 (1)