7 completed, 3 unknown, 2 withdrawn, 1 recruiting. 5 Not applicable, 3 Phase 1, 3 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 2, Unknown 2, Recruiting 1 |
| Phase 1 | 3 | Withdrawn 2, Completed 1 |
| Phase 4 | 3 | Completed 3 |
| Phase 2 | 1 | Completed 1 |
Follow Late Life Depression: new trials by email Literature Review of Late Life Depression trials Research Report on Late Life Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chronic Anergic Depression IDentification - Magnetic Resonance Imaging Exploration in the Elderly of Traits Related to Onset Functional MRI with EEG per MRI - Late Life Depression | Not applicable | Recruiting | University Hospital, Strasbourg, France | 50 | 2025-07-17 | 2026-08-21 |
| One-Year Trajectory of Cognitive Changes in Patients With Late-life Depression in the Short Term Late Life Depression | Unknown | Fujian Medical University | 400 | 2023-06-01 | 2024-06-24 | |
| TBS,TMS, Suicidal Ideation, Magnetic Resonance Imaging, Dorsolateral Prefrontal Cortex, Ventrolateral Prefrontal Cortex Transcranial magnetic stimulation - Late Life Depression | Not applicable | Unknown | Chang Gung Memorial Hospital | 125 | 2021-11-01 | 2024-08-22 |
| SSIPP vs. PST vs. WLC Student-Senior Isolation Prevention Partnership (SSIPP), Problem Solving Therapy (PST). - Major Depressive Disorder, Late Life Depression | Phase 1 | Withdrawn | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2021-08-09 | 2022-04-18 | |
| Dopaminergic Dysfunction in Late-Life Depression L-Dopa, Placebo - Late Life Depression, Cognitive Decline | Phase 2 | Completed | Vanderbilt University Medical Center | 79 | 2021-02-15 | 2026-08-06 |
| Ketamine for Older Adults Pilot Ketamine - Treatment Resistant Depression, Refractory Depression | Phase 4 | Completed | Washington University School of Medicine | 25 | 2020-10-22 | 2023-02-14 |
| Explore the Neural Mechanism of Mindfulness Training to Reduce Loneliness in Depressed Older Adults Mindfulness based stress reduction - Late Life Depression | Not applicable | Unknown | Chang Gung Memorial Hospital | 180 | 2020-08-01 | 2022-11-17 |
| A Breathing-Based Meditation Intervention for Patients With Treatment Resistant Late Life Depression Sudarshan Kriya Yoga - Late Life Depression | Phase 1 | Withdrawn | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2020-01-01 | 2018-06-25 | |
| RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT) Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion - Depression, Dementia | Phase 4 | Completed | Centre for Addiction and Mental Health | 87 | 2019-08-01 | 2024-11-25 |
| Exploration of the Potential Mechanisms of n-3 Fatty Acids Supplementation in Depression and Cognitive Function in Patients With Late-life Depression Omega-3 fatty acids, Soybean oil - Late Life Depression | Not applicable | Completed | Chang Gung Memorial Hospital | 30 | 2018-09-25 | 2023-08-02 |
| CM Delivered PST in LLD Pilot Problem Solving Therapy (PST) - Late Life Depression | Phase 1 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 29 | 2018-02-01 | 2019-06-11 |
| Optimizing Outcomes of Treatment-Resistant Depression in Older Adults Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion - Treatment Resistant Depression, Major Depressive Disorder | Phase 4 | Completed | Washington University School of Medicine | 742 | 2017-02-24 | 2024-10-03 |
| Automatic Self Transcending Meditation (ASTM) Versus Heart Rate Variability (HRV) Biofeedback in Patients With Late Life Depression (LLD): a Longitudinal Pilot Feasibility Study HRV biofeedback, ASTM - Late Life Depression | Not applicable | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 8 | 2013-08-01 | 2014-02-26 |
Depressive Disorder, Major (4) · Depressive Disorder, Treatment-Resistant (4) · Cognitive Dysfunction (2) · Dementia (1) · Depression (1) · Lethargy (1)
Depressive Disorder (5) · Mental Disorders (5) · Mood Disorders (5) · Cognition Disorders (2) · Nervous System Diseases (2) · Neurocognitive Disorders (2) · Behavior (1) · Behavioral Symptoms (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Neurobehavioral Manifestations (1) · Neurologic Manifestations (1) · Pathological Conditions, Signs and Symptoms (1) · Signs and Symptoms (1)
Aripiprazole (2) · Bupropion (2) · Lithium Carbonate (2) · Nortriptyline (2) · Carbidopa (1) · Fatty Acids, Omega-3 (1) · Ketamine (1) · Levodopa (1) · Mindfulness-Based Stress Reduction (1) · Soybean Oil (1) · Transcranial Magnetic Stimulation (1) · carbidopa, levodopa drug combination (1)
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (4) · Chang Gung Memorial Hospital (3) · Washington University School of Medicine (2) · Centre for Addiction and Mental Health (1) · Fujian Medical University (1) · University Hospital, Strasbourg, France (1) · Vanderbilt University Medical Center (1)
Canada (6) · United States (4) · Taiwan (3) · China (1) · France (1)
Eric Lenze, MD (2) · Akshya Vasudev, MBBS MD MRCPSych (1) · Akshya Vasudev, MD (1) · Aristotle Voineskos, MD (1) · Shwu-Hua Lee (1) · Warren Taylor, MD,MHSc (1) · Ziping Zhu (1)
PMID 36867173, PMID 37392089, PMID 38822571, PMID 41237789
R01MH114966 (1), R01MH114970 (1), R01MH114980 (1), R01MH114981 (1)