17 completed, 3 recruiting, 3 unknown, 2 terminated. 26 Phase 1, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 26 | Completed 17, Recruiting 3, Unknown 3, Terminated 2, Withdrawn 1 |
| Phase 2 | 9 | Completed 6, Recruiting 2, Terminated 1 |
Follow Language Disorders: new trials by email Literature Review of Language Disorders trials Research Report on Language Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dopamine and Sensorimotor Function in Stuttering Aripiprazole 10 MG, Placebo - Stuttering, Adult | Phase 1 | Recruiting | University of California, San Francisco | 25 | 2025-09-30 | 2026-08-19 |
| A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound Clemastine Fumarate Combined With Engineered Sound, Clemastine Fumarate Combined With Pink Noise, Placebo Drug With Engineered Sound - Central Auditory Processing Disorder, Hearing Impaired (Partially) | Phase 1 / Phase 2 | Recruiting | University of Colorado, Denver | 344 | 2025-03-31 | 2026-04-30 |
| A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) Intrathalamic AAV.PGRN administration, Intrathalamic AVB-101 - Frontotemporal Dementia, FTD | Phase 1 / Phase 2 | Recruiting | AviadoBio Ltd | 18 | 2023-08-30 | 2026-08-13 |
| Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S QBS10072S - Astrocytoma, Brain Cancer | Phase 1 | Completed | Quadriga Biosciences, Inc. | 15 | 2020-07-20 | 2023-01-18 |
| Proof-of-concept Study of LUNA Intervention in Aphasia LUNA - Aphasia, Stroke | Phase 1 | Completed | City, University of London | 28 | 2020-06-14 | 2023-05-06 |
| Intranasal Inhalations of M2 Macrophage Soluble Factors in Children With Developmental Speech Disorders Bioactive Factors, Produced by M2 Type Macrophages (M2-BFs). - Language Delay, Language; Developmental Disorder, Expressive | Phase 1 / Phase 2 | Completed | Russian Academy of Medical Sciences | 14 | 2020-02-01 | 2022-05-02 |
| BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES BIIB092, Placebo - Primary Tauopathies, Corticobasal Degeneration Syndrome | Phase 1 | Terminated | University of California, San Francisco | 22 | 2018-09-12 | 2019-12-19 |
| A 24-month Phase 1 Pilot Study of AADvac1 in Patients With Non Fluent Primary Progressive Aphasia AADvac1 40 µg, AADvac1 160 µg - Primary Progressive Nonfluent Aphasia | Phase 1 | Unknown | Axon Neuroscience SE | 33 | 2017-07-31 | 2019-11-14 |
| Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal Dementia F-18 AV 1451 - Primary Progressive Aphasia, Behavioral Variant of Frontotemporal Dementia | Phase 1 | Completed | Mayo Clinic | 81 | 2016-07-01 | 2025-11-21 |
| Evaluating Anodal tDCS Preceding Aphasia Therapy transcranial direct current stimulation - Stroke, Aphasia | Phase 1 / Phase 2 | Terminated | Northwell Health | 15 | 2014-09-01 | 2021-04-05 |
| Brief Behavioral Treatment for Anxiety in Young Children Parent-Led Exposure Therapy, Treatment As Usual - Obsessive-compulsive Disorder, Social Phobia | Phase 1 / Phase 2 | Completed | University of South Florida | 58 | 2014-01-01 | 2016-10-06 |
| Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD C-11 PiB - Atypical Alzheimers Disease, Logopenic Variant of Primary Progressive Aphasia (LPA) | Phase 1 | Completed | Mayo Clinic | 27 | 2012-11-01 | 2015-12-21 |
| Effects of tDCS Versus HD-tDCS for Stroke Rehabilitation HD-tDCS (Soterix), Transcranial Direct Current Stimulation (Neuroconn) - Chronic Aphasia | Phase 1 | Completed | Soterix Medical | 2012-03-01 | 2015-08-26 | |
| Building Complex Language Complex sentence treatment protocol - Language Development Disorders, Learning Disorders | Phase 1 / Phase 2 | Completed | Governors State University | 31 | 2011-04-01 | 2013-11-25 |
| The Effects of Tactile Speech Feedback on Stuttering Frequency Tactile Stimulation - Stuttering | Phase 1 | Withdrawn | University of Mississippi, Oxford | 2011-03-01 | 2014-05-12 | |
| Transcranial Direct Current Stimulation and Aphasia Language Therapy Transcranial Direct Current Stimulation - Cathodal stimulation, Transcranial Direct Current Stimulation - Anodal stimulation, Transcranial Direct Current Stimulation - Sham stimulation - Nonfluent Aphasia, Stroke | Phase 1 | Completed | Shirley Ryan AbilityLab | 12 | 2010-03-01 | 2017-05-15 |
| PiB PET Scanning in Speech and Language Based Dementias C-11 PiB, F-18 FDG - PPA, Primary Progressive Aphasia | Phase 1 | Completed | Mayo Clinic | 168 | 2010-03-01 | 2015-12-22 |
| Davunetide (AL-108) in Predicted Tauopathies - Pilot Study davunetide (AL-108, NAP), Placebo nasal spray - Predicted Tauopathies, Including, Progressive Supranuclear Palsy | Phase 1 | Completed | University of California, San Francisco | 12 | 2010-01-01 | 2019-04-05 |
| My Scrivener® - Measuring Effectiveness and Dose Response in Children My Scrivener(R) - Asperger's Syndrome, Dyslexia | Phase 1 / Phase 2 | Completed | Obslap Research LLC | 176 | 2009-04-01 | 2010-10-28 |
| Implementation of Climb Up Program for Children With Attention Deficit Hyperactivity Disorder (ADHD) and Dyslexia in a School in India Climb Up ADHD and Dyslexia Program - Attention Deficit Hyperactivity Disorder, Dyslexia | Phase 1 / Phase 2 | Completed | Climb Up Kids | 76 | 2007-05-01 | 2015-08-04 |
Showing 20 of 26. Sign in to see all of them.
Stroke (9) · Aphasia (8) · Aphasia, Primary Progressive (4) · Language (4) · Language Development Disorders (4) · Primary Progressive Nonfluent Aphasia (4) · Aphasia, Broca (3) · Attention Deficit Disorder with Hyperactivity (3) · Frontotemporal Dementia (3) · Pick Disease of the Brain (3) · Apraxias (2) · Developmental Disabilities (2) · Dyslexia (2) · Ischemic Stroke (2) · Speech (2)
Nervous System Diseases (26) · Neurobehavioral Manifestations (26) · Neurologic Manifestations (26) · Pathological Conditions, Signs and Symptoms (26) · Signs and Symptoms (26) · Communication Disorders (25) · Brain Diseases (18) · Central Nervous System Diseases (18) · Speech Disorders (18) · Mental Disorders (13) · Cardiovascular Diseases (9) · Cerebrovascular Disorders (9) · Vascular Diseases (9) · Neurodevelopmental Disorders (7)
Transcranial Direct Current Stimulation (3) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (2) · AADvac1 (1) · Aripiprazole (1) · Clemastine (1) · Levetiracetam (1) · Placebo Effect (1) · Therapeutics (1) · Transcranial Magnetic Stimulation (1) · davunetide (1) · gosuranemab (1)
Mayo Clinic (3) · University of California, San Francisco (3) · AviadoBio Ltd (1) · Axon Neuroscience SE (1) · Boston University (1) · City, University of London (1) · Climb Up Kids (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Governors State University (1) · Kessler Foundation (1) · Northstar Neuroscience (1) · Northwell Health (1) · Obslap Research LLC (1) · Quadriga Biosciences, Inc. (1) · Rush University Medical Center (1)
United States (20) · United Kingdom (2) · Australia (1) · Belgium (1) · Canada (1) · Germany (1) · India (1) · Italy (1) · Netherlands (1) · Poland (1) · Russia (1) · Spain (1) · Sweden (1)
A.M. Barrett, MD (1) · Achim Klug, PhD (1) · Adam Boxer, MD, PhD (1) · Adam L. Boxer, M.D., Ph.D. (1) · Alexander A Ostanin, MD, PhD (1) · Alvaro Pascual-Leone, M.D., Ph.D. (1) · Bruce Crosson, PhD (1) · Catherine H Balthazar, PhD (1) · Cheryl M Scott, PhD (1) · Devendra Mehta, MBBS MSC MRCP (1) · Dwight E Waddell, Ph.D. (1) · Elena R Chernykh, MD, PhD (1) · Emily Wang, PHD (1) · H B Coslett, M.D. (1) · Harris S. Huberman, MD (1)
PMID 15118944, PMID 15766771, PMID 16006338, PMID 19425468, PMID 19695692, PMID 20159655, PMID 20299861, PMID 21794852, PMID 21864891, PMID 23106988, PMID 23280015, PMID 26704258, PMID 29256908, PMID 38875279
2017 (1), 2023 (1), R01DC005672 (1), R01DC007387 (1), R21DC009876 (1), R21DC021557 (1), R21NS094684 (1), R41NS076123 (1)