308 completed, 120 recruiting, 84 unknown, 21 active not recruiting. 420 Not applicable, 42 Phase 2, 20 Phase 1, 17 Phase 3, 7 Phase 4.
Follow Speech Disorders: new trials by email Literature Review of Speech Disorders trials Research Report on Speech Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy Lateral spinal cord surgical implant of electrodes - Cerebral Palsy, Spasticity | Not applicable | Not yet recruiting | Juan Carlos M. Andreani MD | 40 | 2027-06-01 | 2026-04-28 |
| Combined Intervention Program for Non-fluent Aphasia Based on Neuroplasticity CIPAN = MIT + CIAT, MIT + MIT, CIAT + CIAT - Non-fluent Aphasia | Not applicable | Not yet recruiting | Universidad de Granada | 48 | 2027-01-01 | 2026-08-14 |
| Deep Brain Stimulation + Therapy for Stroke Boston Scientific Vercise Deep Brain Stimulation (DBS) System, Rehabilitation Training Protocol - Stroke, Dysarthria | Not applicable | Not yet recruiting | Pirondini, Elvira, PhD | 15 | 2027-01-01 | 2026-09-30 |
| Listen Aphasia Pilot Study LISTEN (AI-based AAC smartphone app) - Aphasia, Malignant Brain Tumor | Not applicable | Not yet recruiting | Dana-Farber Cancer Institute | 80 | 2027-01-01 | 2026-07-28 |
| BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Aphasia BrainGate Neural Interface System - Expressive Aphasia, Aphasia Following Cerebral Infarction | Not applicable | Not yet recruiting | Leigh R. Hochberg, MD, PhD. | 5 | 2026-11-01 | 2026-10-22 |
| Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive Screen Stroke, Ischemic Stroke | Not yet recruiting | University of Copenhagen | 180 | 2026-11-01 | 2026-10-27 | |
| Effectiveness of Virtually Simulated Intervention for Patients Having Stuttering Virtually Simulated Intervention, Traditional Speech Therapy - Stuttering | Not applicable | Not yet recruiting | Riphah International University | 44 | 2026-10-25 | 2026-09-28 |
| Effects of Semantic Context on Criterion-learning Naming Treatment in Aphasia Criterion-learning practice - Aphasia | Not applicable | Enrolling by invitation | Albert Einstein Healthcare Network | 12 | 2026-10-20 | 2026-10-28 |
| Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS) Chronic speech BCI - Locked in Syndrome, ALS (Amyotrophic Lateral Sclerosis) | Not applicable | Not yet recruiting | University Hospital, Grenoble | 3 | 2026-10-10 | 2026-07-13 |
| Development and Pilot Testing of Virtually Simulated Intervention for Patients Having Stuttering Virtually Simulated Intervention - Stuttering | Not applicable | Not yet recruiting | Riphah International University | 10 | 2026-09-10 | 2026-09-22 |
| Study of Cognitive-Linguistic Profiles: The Role of Executive Control in Aphasia Neuropsychological tests, Speech-language assessments - Stroke | Not applicable | Not yet recruiting | University Hospital, Toulouse | 30 | 2026-09-01 | 2026-08-14 |
| Cross-cultural Adaptation and Multicenter Validation of the Italian Versions of the Brief Evaluation of Receptive Aphasia (BERA) and SWallowing Assessment in Disorders of Consciousness (SWADOC) Italian SWallowing Assessment in Disorders of Consciousness (SWADOC), Italian Brief Evaluation of Receptive Aphasia (BERA) - Consciousness Disorders, Severe Acquired Brain Injury | Not yet recruiting | Alfonso Magliacano | 79 | 2026-09-01 | 2026-07-17 | |
| Wireless Implantable Mandarin Chinese Speech Neuroprosthesis Evaluation WRS - Speech Disorder | Not applicable | Recruiting | Shanghai StairMed Technology Co., Ltd. | 4 | 2026-09-01 | 2026-09-11 |
| Noninvasive Thalamocortical Neuromodulation With Low-Intensity Focused Ultrasound for Persistent Developmental Stuttering High DC LIFU, Sham - Stuttering, Developmental Stuttering | Not applicable | Recruiting | University of Michigan | 20 | 2026-08-19 | 2026-09-15 |
| Large Language Models for Stuttering Assessment and Therapy ChatGPT-Generated Responses, Claude-Generated Responses, Google Gemini-Generated Responses - Stuttering | Completed | Istanbul Gelisim University | 5 | 2026-08-07 | 2026-09-22 | |
| Desensitization-Based Structured Intervention Program for Individuals With Stuttering Structured Desensitization-Based Job Interview Program - Stuttering | Not applicable | Recruiting | DİLARA BASER | 36 | 2026-07-20 | 2026-08-14 |
| Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation tDCS - Aphasia, Broca's Aphasia | Phase 2 / Phase 3 | Recruiting | University of South Carolina | 130 | 2026-07-14 | 2026-07-21 |
| Investigating Individual Differences in Speech Motor Skills in Neurotypical Speakers and Persons With Disordered Speech Unpredictable auditory feedback perturbation: 2 behavioral sessions, Unpredictable auditory feedback perturbation during tCS: 3 behavioral sessions, Sustained F1 auditory feedback perturbation - Stuttering, Developmental, Dyslexia | Not applicable | Recruiting | Boston University Charles River Campus | 90 | 2026-06-12 | 2026-07-21 |
| Stimulating the Aging Brain Using Brain and Sensory Stimulation tACS or multisensory stimulation - Primary Progressive Aphasia | Not applicable | Recruiting | Medical College of Wisconsin | 20 | 2026-06-01 | 2026-06-16 |
| Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe continuous Theta Burst Stimulation, intermittent Theta Burst Stimulation, Transcranial Magnetic Stimulation Sham - Stroke, Aphasia | Not applicable | Recruiting | University of South Carolina | 45 | 2026-05-15 | 2026-05-29 |
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Aphasia (324) · Stroke (194) · Aphasia, Primary Progressive (75) · Stuttering (70) · Dysarthria (57) · Communication Disorders (54) · Language (40) · Aphasia, Broca (35) · Frontotemporal Dementia (35) · Speech (34) · Parkinson Disease (31) · Language Disorders (30) · Anomia (29) · Alzheimer Disease (28)
Pathological Conditions, Signs and Symptoms (595) · Neurobehavioral Manifestations (593) · Neurologic Manifestations (592) · Signs and Symptoms (592) · Nervous System Diseases (590) · Language Disorders (565) · Communication Disorders (541) · Central Nervous System Diseases (341) · Brain Diseases (335) · Cardiovascular Diseases (213) · Vascular Diseases (212) · Cerebrovascular Disorders (210) · Mental Disorders (196) · Behavior (104)
Transcranial Direct Current Stimulation (48) · Speech Therapy (24) · Transcranial Magnetic Stimulation (21) · Language Therapy (10) · Therapeutics (6) · Control Groups (4) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (3) · Exercise (3) · Fluoxetine (3) · Blood Specimen Collection (2) · Cognitive Behavioral Therapy (2) · D-JNKI-1 (2) · Deep Brain Stimulation (2) · Donepezil (2) · Drug Delivery Systems (2)
VA Office of Research and Development (17) · Johns Hopkins University (12) · University of Pennsylvania (12) · Shirley Ryan AbilityLab (10) · Medical College of Wisconsin (9) · Riphah International University (9) · Changping Laboratory (8) · University of Chicago (8) · University of California, San Francisco (7) · University of Michigan (7) · University of Pittsburgh (7) · Boston University Charles River Campus (6) · Mayo Clinic (6) · National Institute on Deafness and Other Communication Disorders (NIDCD) (6) · Albert Einstein Healthcare Network (5)
United States (298) · France (31) · Canada (28) · United Kingdom (28) · Germany (21) · Pakistan (19) · Italy (18) · China (17) · Spain (15) · Turkey (Türkiye) (15) · Belgium (10) · Sweden (10) · Switzerland (10) · Hong Kong (8) · South Korea (8)
Hesheng Liu, PhD (6) · H. Branch Coslett, MD (4) · Kyrana Tsapkini, PhD (4) · Maya L Henry, PhD (4) · Amy D. Rodriguez, PhD (3) · Julie L Wambaugh, PhD (3) · Leora Cherney, PhD (3) · Min Ney Wong, PhD (3) · Priyanka Shah-Basak, PhD (3) · Soo-Eun Chang, PhD (3) · William Evans, PhD (3) · Agnes Floel, MD (2) · Alexander P Leff, Professor (2) · Aneta Kielar, PhD (2) · Carolyn I Rodriguez, MD, PhD (2)
PMID 15118944, PMID 19695692, PMID 20299861, PMID 30128538, PMID 33441454, PMID 10350414, PMID 10568646, PMID 10796360, PMID 10917410, PMID 10990547, PMID 11556941, PMID 11849307, PMID 12849360, PMID 14502069, PMID 15026214, PMID 15087552, PMID 15109995, PMID 15212606, PMID 15328899, PMID 15766771, PMID 16006338, PMID 16635494, PMID 16737714, PMID 17030751, PMID 17900904, PMID 18030084, PMID 19158063, PMID 19425468, PMID 19453637, PMID 19673813, PMID 19818232, PMID 20013046, PMID 20040569, PMID 20075648, PMID 20159655, PMID 20438853, PMID 20714075, PMID 21197418, PMID 21233468, PMID 21391024, PMID 21636820, PMID 21794852, PMID 21825004, PMID 21842404, PMID 21864891, PMID 22215032, PMID 23050517, PMID 23071199, PMID 23108446, PMID 23280015
R01AG055425 (4), P50DC014664 (3), R01DC015516 (3), 2016 (2), 2019 (2), P01AG066597 (2), R01DC019325 (2), 1DP2DC021055 (1), 1RF1AG050967-01A1 (1), 2017 (1), 2023 (1), F31DC020121 (1), F31DC020352 (1), I01RX000832 (1), I21RX002566 (1)